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Prof. Asish Pal

Scientist-F (Professor)

Development of supramolecular polymeric hydrogel based biomaterials for ECM mimick and tissue engineering, Stimuli-responsive materials for controlled release and delivery, Dynamic combinatorial chemistry for self-healing and functional nanomaterials, Multivalent recognition for imaging and diagnostic application

CONTACT INFORMATION :

Research Interest

  • The development of synthetic biomimetic scaffolds that can provide cues for cell-matrix interfaces can dictate cell migration direction and stimulate tissue growth promises materials for next-generation artificial ECM mimetic biomatrix. In quest of designing such materials recently we developed organic-inorganic hybrid systems like peptide template bioglass materials which were utilised as self-healing bone tissue matrix for osteoblast cell growth. Currently, with our expertise in supramolecular chemistry, we are exploring the possibility of controlling mechanical insights such as dynamic mechanical stiffening and compression response of peptide-polymer conjugates as surrogate extracellular matrix materials.

     

    Our report in the field:

    1. N. Gupta et al. Chem. Mater. 2021, 33, 589–599.

    2. J. Thomas, N. Gupta et al. ACS. Biomater. Sci. Eng. 2021, Accepted

  • Nature has an unprecedented handle over the conformation and dynamics of its macromolecular morphologies. One of such examples is the finite arrangement of amino acids in the living system into a spatial organization through chain folding that can carry out specific functions like enzymatic catalysis in an extremely efficient way. These intricate structure-activity relationships observed in biopolymers like proteins inspired us to design synthetic macromolecular architectures by bottom-up approach. Since 2017, we have designed a number of single-chain functional polymers using a variety of polymer synthesis protocols such as ATRP, RAFT etc. This polymers endowed stimuli-responsive chain collapse to form precisely controlled nanoparticles, which by mediation of thermo-responsive copolymers is exploited towards thermal homeostasis of drug release. Currently, we are looking at interesting convertible nanostructures from precisely controlled segmented block-copolymers for targeted drug delivery applications.

     Additionally, photofixation of functional moieties in the polymer modulate the glass transition temperature and resultant chain flow behaviour that have been utilized in low viscosity polymer film self-healing, that is being considered for coating application. Further, tweaking such polymers anchored with paramagnetic nanoparticles we are exploring different self-healing mechanism.

     

    Our reports in the field:

    1. J. P. Joseph et al. Soft Matter, 2020, 16, 2506-2515.

    2. J. P. Joseph et al. Polym. Chem., 2021, 12, 1002-1013. 

    3. C. Miglani et al. RSC Advances, 2021, Accepted

  • Nature is a seamless designer to provide complex functional architectures through molecular self-assembly guided by out-of-equilibrium mechanism. Self-assembly hitherto performed in the lab under thermodynamic control results in a precise single state owing to minimalized Gibb’s free energy. In contrast, kinetic control over the self-assembly pathway allows to trap some of the intermediates over the trail of the process. Since 2015, we are trying to explore various method to kinetically control multi-step self-assembly using living supramolecular polymerization in our lab. Recently, we have been able to accomplish such pathway dependant self-assembly in amyloid inspired minimalistic peptide system to form 1D fiber, twisted bundle and 2D lamellar morphologies. Moreover, the nanostructures were precisely controlled in length and dimension via seeded supramolecular polymerization. Such functional systems were utilized for rendering a better mechanical strength control of resultant hydrogels, efficient MoS2 exfoliation, chiral self-sorting vs. co-assembly, organic catalysis etc.

     

    Our reports in the field:

    1. A. Singh et al. Chem. Commun., 2018, 54, 10730—10733.

    2. J. P. Joseph et al. ACS Appl. Mater. Interfaces 2019, 11, 28213–28220.

    3. D. Gupta et al. Nanoscale, 2020, 12, 18692-18700.

    4. A. Singh et al. Nanoscale, 2021, 13, 13401-13409.

  • Hydrogels materials from amino acids, lipids, sugars and polymer possess a three-dimensional network structure with thermal and mechanical stability that can be utilized to retain water and drug molecules. Recently, we started exploring this field including development of hydrogel beads that employs minimal water usage and sufficient fertilizers to grow a plant in semi-arid areas under adverse weather conditions and peptide-prodrug system to deliver drug via enzymatic degradation.  

     

    Our report in the field:

    1. J. P. Joseph et al. RSc Advances, 2019, 9, 19819-198272.

  • Development of chiral molecules on peptide and polymeric platforms that can be exploited for chiral sensing and recognition applications.  

     

    Our report in the field:

    1. B. Sharma et al. New J. Chem., 2018, 42, 6427-6432. 

Research Highlights

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Research Associates

  • Mala Thapa

    Email: mala.rp962141@inst.ac.in

    Reg. No.: RP962141

    Working Since Apr, 2022

  • DR. ANAND KUMAR AWASTHI

    Email: anand.ra202138@inst.ac.in

    Reg. No.: RA-01-202138

    Working Since Apr, 2022

PhD Students

  • MR. VYSAKH C C

    Email: vysakh.ph21238@inst.ac.in

    Reg. No.: PH21238

    Working Since Jan, 2022

  • Ms. Jahanvi Ralhan

    Email: jahanvi.ph21207@inst.ac.in

    Reg. No.: PH21207

    Working Since Aug, 2021

  • Mr. Debasish Nath

    Email: debasish.ph20259@inst.ac.in

    Reg. No.: PH20259

    Working Since Jan, 2021

  • Ms. Antarlina Maulik

    Email: antarlina.ph20202@inst.ac.in

    Reg. No.: PH20202

    Working Since Aug, 2020

  • Ms. Nimisha Atul Mavlankar

    Email: nimisha.ph19215@inst.ac.in

    Reg. No.: PH19215

    Working Since Aug, 2019

  • Mr.Chirag Miglani

    Email: chirag.ph17229@inst.ac.in

    Reg. No.: PH17229

    Working Since Jan, 2018

  • Ms. Deepika Gupta

    Email: deepika.ph16216@inst.ac.in

    Reg. No.: PH16216

    Working Since Aug, 2016

Post Doc Fellows

  • Dr. Jojo P Joseph

    Email: jojo.ph15211@inst.ac.in

    Reg. No.: PH15211

  • Dr. Nidhi Gupta

    Email: nidhigupta87@gmail.com

    Reg. No.: PDF1902


PhD Students

  • Dr. Ashmeet Singh

    Email: mail2ashmeet2@gmail.com

    Reg. No.: PH14207


  1. Unraveling On-demand Strain-Stiffening in Nanofibrous Peptide–Polymer Conjugates to Mimic Contractility in Actinomyosin Networks: Jojo P. Joseph, Nidhi Gupta, Chirag Miglani, Debasish Nath, Ashmeet Singh, Deepika Gupta, Asish Pal*, (2022) Chem Mater, 34: 4364-4374 (IF = 9.81). DOI: 10.1021/acs.chemmater.1c04301

  2. Photochemically Sequestered Off-Pathway Dormant States of Peptide Amphiphiles for Predictive On-Demand Piezoresponsive Nanostructures: Deepika Gupta, Ashish Bhatt, Varun Gupra,Chirag Miglani, Jojo P. Joseph, Jahanvi Ralhan,Dipankar Mandal*, Md. Ehesan Ali*, Asish Pal*, (2022) Chem Mater, 34: 4456-4470 (IF = 9.81). DOI: 10.1021/acs.chemmater.2c00228

  3. Surface-Engineered Mucus Penetrating Nucleic Acid Delivery Systems with Cell Penetrating Peptides for the Lungs: Anupama Kumari,Simanti Pal,Betsy Resma G,Franklin P Mohny,Nidhi Gupta,Chirag Miglani,Bijay Pattnaik,Asish Pal*,Munia Ganguli*, (2022) Molecular Pharmaceutics, 19: 1309-1324 (IF = 4.94).

  4. Mechanical Integrity in Dynamic Interpenetrating Hydrogel Network of Supramolecular Peptide-Polysaccharide Supports Enhanced Chondrogenesis: Jijo Thomas,Nidhi Gupta,Jojo P. Joseph,Vianni Chopra,Asish Pal,Deepa Ghosh, (2021) ACS Biomater. Sci. Eng., 7: 5798–5809 (IF = 4.4). DOI: 10.1021/acsbiomaterials.1c01120

  5. Modulation of Flexo-Rigid Balance in Photoresponsive Thymine Grafted Copolymers towards Designing Smart Healable Coating: Chirag Miglani,Jojo P. Joseph,Deepika Gupta,Ashmeet Singh,Asish Pal, (2021) RSC Advances, 11: 39376 - 39386 (IF = 3.24). DOI: 10.1039/D1RA07425C

  6. Photothermally Switchable Peptide Nanostructures towards Modulating Catalytic Hydrolase Activity: Ashmeet Singh, Jojo P. Joseph, Deepika Gupta, Chirag Miglani, Nimisha A. Mavlankar, Asish Pal, (2021) Nanoscale, 13: 13401-13409 (IF = 7.79). DOI: 10.1039/D1NR03655F

  7. Complexation of an Azo Dye by Cyclodextrins: A Potential Strategy for Water Purification: Anas Saifi,Jojo P. Joseph,Atul P. Singh ,Asish Pal,Kamlesh Kumar, (2021) ACS Omega, 6: 4776-4782 (IF = 3.5). DOI: 10.1021/acsomega.0c05684

  8. Delineating synchronized control of dynamic covalent and non-covalent interactions for polymer chain collapse towards cargo localization and delivery: Jojo P Joseph ,Chirag Miglani,Aashish Bhatt,Debes Ray,Ashmeet Singh,Deepika Gupta,Md Ehesan Ali,Vinod K Aswal,Asish Pal, (2021) Polym. Chem., 12: 1002 -1013 (IF = 5.34). DOI: 10.1039/D0PY01551B

  9. Pathway-Driven Peptide-Bioglass Nanocomposites as the Dynamic and Self-Healable Matrix: Nidhi Gupta,Ashmeet Singh ,Namit Dey ,Sabyasachi Chattopadhyay ,Jojo P. Joseph ,Deepika Gupta ,Munia Ganguli ,Asish Pal, (2021) Chem. Mater., 33: 589-599 (IF = 9.81). DOI: 10.1021/acs.chemmater.0c03757

  10. Enzyme Responsive Chiral Self-sorting in Amyloid-inspired Minimalistic Peptide Amphiphiles: Deepika Gupta, Ranjan Sasmal, Ashmeet Singh, Jojo P. Joseph, Chirag Miglani, Sarit S. Agasti, Asish Pal, (2020) Nanoscale, 12: 18692 - 18700 (IF = 7.79). DOI: 10.1039/D0NR04581K

  11. Photoresponsive Chain Collapse in Flexo-rigid Functional Copolymer to Modulate Self-healing Behavior: Jojo P. Joseph,Chirag Miglani,Ashmeet Singh,Deepika Gupta,Asish Pal, (2020) Soft Matter, 16: 2506-2515 (IF = 3.68). DOI: 10.1039/D0SM00033G

  12. Tandem Interplay of Host-guest Interaction and Photo-responsive Supramolecular Polymerization to 1D and 2D Functional Peptide Materials: Jojo P Joseph, Ashmeet Singh,Deepika Gupta, Chirag Miglani,Asish Pal, (2019) ACS Applied Mater Interface, 11: 28213-28220 (IF = 9.2). DOI: 10.1021/acsami.9b09690

  13. Supramolecular Gels from Sugar-linked Triazole Amphiphiles for Drug Entrapment and Release for Topical Application: Komal Sharma, Jojo P. Joseph, Adarsh Sahu, Narender Yadav, Mohit Tyagi, Ashmeet Singh,Asish Pal,K. P. R. Kartha, (2019) RSC Advances, 9: 19819 - 19827 (IF = 3.24). DOI: 10.1039/C9RA02868D

  14. Pathway Driven Self-assembly and Living Supramolecular Polymerization in Amyloid-inspired Peptide Amphiphile,: Ashmeet Singh, Jojo P. Joseph, Deepika Gupta,Indranil Sarkar,Asish Pal, (2018) Chem Comm, 54: 10730-10733 (IF = 6.0). DOI: 10.1039/C8CC06266H

  15. Chirality control to multi-stimuli responsive and self-healing supramolecular metallo-hydrogels: Bhagwati Sarma,Ashmeet Singh,Tridib K. Sarma,Neha Sardana,Asish Pal, (2018) New J. Chem, 42: 6427-6432 (3.59). DOI: 10.1039/C8NJ00218E

  16. Mechanism of Building Block Exchange in Stacks of Self-replicating Macrocycles: Elio Mattia,Giulia Leonetti,Sijbren Otto,Asish Pal, (2017) Synlett, 28: 103-107. DOI: 10.1055/s-0036-1589709

  17. Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: M. Yagiz Unver,Matthijs Bakker, Stephan P. Berrier, Anna K. H. Hirsch,Asish Pal,Milon Mondal, (2016) Chem. Eur. J., 22: 14826–14830. DOI: 10.1002/chem.201603001

  18. Multi-step control over self-assembled hydrogels of peptide-derived building blocks and a polymeric cross-linker: Van Duc Nguyen,Asish Pal,Frank Snijkers,Mathieu Colomb-Delsuc ,Giulia Leonetti ,Sijbren Otto,Jasper van der Gucht, (2016) Soft Matter, 12: 432-440. DOI: 10.1039/C5SM02088C

  19. Controlling the Structure and Length of Self-synthesizing Supramolecular Polymers through Nucleated Growth and Disassembly: Sijbren Otto,Asish Pal,Morteza Malakoutikhah ,Giulia Leonetti,Meniz Tezcan,Mathieu Colomb-Delsuc,Van Duc Nguyen,Jasper van der Gucht ,Sijbren Otto, (2015) Angew. Chem. Int. Ed., 54: 7852-7856. DOI: 10.1002/anie.201501965

  20. Topochemical Polymerization in Self-assembled Rodlike Micelles of Bisurea Bolaamphiphiles: Asish Pal,Panayiotis Voudouris,marcel M. E. Koenigs ,Pol Besenius ,Hans M. Wyss,Volcan Degirmenci,Rint. P. Sijbesma, (2014) Soft Matter, 10: 952-956. DOI: 10.1039/C3SM52605D

  21. Tuning Crosslink Density in a Physical Hydrogel by Supramolecular Self-sorting.: Marcel Koenigs,Hamed Mortazavi, Gajanan Pawar, Kees Storm, Rint P. Sijbesma,Asish Pal, (2014) Macromolecules, 47: 2712-2717. DOI: 10.1021/ma500446g

  22. SANS Studies of Mixed Micellar Structures made of Dimeric Surfactants having Imidazolium and Ammonium Headgroups: Sougata Dutta, V. K. Aswal,Santanu Bhatttacharya,Asish Pal, (2012) J. Phys. Chem. B, 116: 13239-13247. DOI: 10.1021/jp304700t

  23. Self-Sorting in Rodlike Micelles of Chiral Bisurea Bolaamphiphiles: Asish Pal, Pol Besenius, Rint P. Sijbesma, (2011) J. Am. Chem. Soc, 133: 12987-12989 (IF = 15.42). DOI: 10.1021/ja205345e

  24. An Insight into Fiber-Solvent Mediated Modulation of Nano-fibrillar Organogels: Suman K. Samanta,Santanu Bhatttacharya,Asish Pal, (2011) Int. J. Nanosci., 10: 547-554. DOI: 10.1142/S0219581X11009374

  25. Coexisting Hydrophobic Compartments through Self-Sorting in Rod-like Micelles of Bisurea Bolaamphiphiles.: S. Karthikeyan, Rint P. Sijbesma,Asish Pal, (2010) J. Am. Chem. Soc, 132: 7842-7843. DOI: 10.1021/ja101872x

  26. Carbon nanotube reinforced supramolecular gels with electrically conducting, viscoelastic and near-infrared sensitive properties: Suman K. Samanta,Santanu Bhattacharya, C.N.R. Rao,Asish Pal, (2010) J. Mater. Chem., 20: 6881-6890. DOI: 10.1039/C0JM00491J

  27. Role of Capping Ligands on the Nanoparticles in the Modulation of Properties of a Hybrid Matrix of Nanoparticles in a 2D Film and in a Supramolecular Organogel.: Asish Pal,Santanu Bhattacharya, (2009) Chem. Eur. J., 15: 9169-9182. DOI: 10.1002/chem.200900304

  28. Structure and properties of two component hydrogels comprising lithocholic acid and organic amines: Hajra Basit, Saikat Sen, Vinod K. Aswal, Santanu Bhattacharya,Asish Pal, (2009) J. Mater. Chem, 19: 4325-4334. DOI: 10.1039/B903407B

  29. Choice of the End Functional Groups in Oligo(p-Pheylenevinylene) Systems Controls the Physical Gelation Efficiency.: Suman K. Samanta,Asish Pal,Santanu Bhattacharya, (2009) Langmuir, 25: 8567-8578. DOI: 10.1021/la8036154

  30. Two Component Hydrogels Comprising Fatty Acids and Amines: Structure, Properties and Application as Template for Metal Nanoparticle Synthesis: Hajra Basit,Asish Pal,Saikat Sen,Santanu Bhattacharya, (2008) Chem. Eur. J., 14: 6534-6545. DOI: 10.1002/chem.200800374

  31. Physical Gelation of Binary Mixtures of Hydrocarbons Mediated by n-Lauroyl-L-Alanine and Characterization of their Thermal and Mechanical Properties: Santanu Bhattacharya,Asish Pal, (2008) J. Phys. Chem. B, 112: 4918-4927. DOI: 10.1021/jp7104715

  32. Synthesis and Properties of Novel Nanocomposites made of Single-Walled Carbon Nanotubes and Low Molecular Mass Organogels and their Thermo-responsive Behavior Triggered by Near IR Radiation: Bhupender S. Chhikara, A. Govindaraj, Santanu Bhattacharya, C.N.R. Rao,Asish Pal, (2008) J. Mater. Chem., 18: 2593-2600. DOI: 10.1039/B719432C

  33. Molecular mechanism of physical gelation of hydrocarbons by fatty acid amides of natural amino acids: Yamuna K. Ghosh,Asish Pal,Santanu Bhattacharya, (2007) Tetrahedron, 63: 7334-7348. DOI: 10.1016/j.tet.2007.05.028

  34. Modulation of Viscoelastic Properties of Physical Gels by Nanoparticle Doping: Influence of the Nanoparticle Capping Agent.: Santanu Bhattacharya, Aasheesh Srivastava,Asish Pal, (2006) Angew. Chem. Int. Ed., 45: 2934-2937. DOI: 10.1002/anie.200504461

  1. Self-healing materials from crystalline polymer composites: Jojo P. Joseph,Ashmeet Singh,Asish Pal, (2017) Springer, Switzerland, 181-218.

  1. Self-synthesizing materials with narrow length distribution through living supramolecular polymerization: Giulia Leonetti, Mathieu Colomb-Delsuc, Jasper van der Gucht, Sijbren Otto,Asish Pal, (2014) .

  2. Tuning the Properties of Photo-induced Hydrogels Obtained from Self-Replicating Peptide Fibers: Jianwei Li, Mathieu Coulomb-Delsuc, Morteza Malakoutikhah, Sijbren Otto,Asish Pal, (2013) .

  3. Towards Out-of-equilibrium Self-assembly:: Jianwei Li, Sijbren Otto, (2012) .

  4. Enantiomeric compartments through self-sorting of rod-like micelles of chiral bisurea bolaamphiphiles: Asish Pal,Rint P. Sijbesma, (2011) .

  5. Dynamic Hydrophobic Compartments through Self-sorting of Rod-like Micelles of Bisurea Bolaamphiphiles: presentation in Dutch Polymer Days, (2010) .

  6. Delineating the Influence of Capping Agents on Metal Nanoparticle-Low Molecular Mass Gel composites: Barbara, USA in Aug, (2007) .

Fundings

  • Biomineralized core-shell polymeric hydrogel beads for controlled fertilizer release and moisture retention under adverse weather conditions 1.8 years, BIRAC PACE
    Funding Amount: 44.10lakh
    PI: Prof. Asish Pal
  • Design of Biomimetic Materials with Strain-stiffening Characteristics for Implication in Cellular Response 3 years, SERB-CRG
    Funding Amount: 35.80 lakh
    PI: Prof. Asish Pal
  • Development of advanced third generation matrix associated chondrocytes for cartilage repair 3 years, DBT-Biocare
    Funding Amount: 174 Lakh
    PI: Prof. Asish Pal
  • SANS study to probe collapse of Single Chain Polymer into discrete Nanoparticles 3 years, UGC-DAE-CSR
    Funding Amount: 1.35 lakh
    PI: Prof. Asish Pal
  • Surface modification for better adhesion property between rubber and textiles 1.5 years, SRF Industrial Project
    Funding Amount: 30 Lakh
    PI: Prof. Asish Pal
  • Stimuli-responsive collapse of tailored single chain functional polymer to diverse hierarchical nanostructures for catalysis and self-healing applications 3 years, SERB-ECR
    Funding Amount: 39.96 Lakh
    PI: Prof. Asish Pal

  • 2009

    PhD

    Dept of Organic Chemistry, Indian Institute of Science (IISc), Bangalore, India

  • 2004

    Master of Science (MS)

    Chemical Science Division, Indian Institute of Science (IISc), Bangalore, India

  • 2001

    Bachelor of Science

    Narendrapur Ramakrishna Mission Residential College, University of Calcutta, India

  • 1998

    Higher Sececondary

    Malda Zilla School

  • 1996

    Secondary

    Malda Zilla School

  • Professor (Scientist-F):Chemical Biology Unit, Institute of Nano Science & Technology, Sector 81, Mohali, Punjab (January 2021 to Present till date )

  • Associate Professor (Scientist-E):Chemical Biology Unit, Institute of Nano Science & Technology, Mohali, India (May 2015 to December 2020 )

  • Postdoctoral Research Fellow with Prof. Sijbren Otto:Stratingh Institute of Chemistry, University of Groningen, The Netherlands (March 2012 to March 2015 )

  • Postdoctoral Research Fellow with Prof. Rint P. Sijbesma:Molecular Science & Technology, Eindhoven University of Technology, Eindhoven, The Netherlands (March 2009 to March 2012 )

Awards & Honours

  • Young Scientist from ECOST

  • National Eligibility Test (NET) from CSIR-UGC

  • IISc Integrated PhD fellowship


Professional Recognitions

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