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Dr. Surajit Karmakar

Professor (Scientist-F)

Development of cancer nano-therapeutics including screening of peptide and small molecule combinatorial therapy, siRNA delivery and peptide-mediated cancer therapy by targeting mitochondrial metabolism. Understanding molecular mechanisms to overcome resistance to chemotherapy, target validation, signal transduction in membrane proteins and nanoparticles endocytotic cascade. Receptor and ion channel regulation on cell membrane organization, endosomal function and escape.

CONTACT INFORMATION :

Research Interest

    • Development of nano-therapeutics including screening of peptide and small molecule combinatorial therapy, siRNA delivery and peptide-mediated cancer therapy by targeting mitochondrial metabolism. Understanding the molecular mechanisms of diabetic retinopathy and their prevention by nanotherapy. To overcome resistance to chemotherapy, target validation, signal transduction in membrane proteins and nanoparticles endocytotic cascade. Receptor and ion channel regulation on cell membrane organization, endosomal function and escape. Understanding the molecular mechanisms of Parkinson’s disease and Alzheimer's disease and developing their prevention by nanotherapy.

Research Highlights

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PhD Students

  • MR. VIJAY KUMAR

    Email: vijay.ph20226@inst.ac.in

    Reg. No.: PH20226

    Working Since Aug, 2020

  • Ms. Babita Kaundal

    Email: babita.ph16209@inst.ac.in

    Reg. No.: Ph16209

    Working Since Aug, 2016

  • Ms. Shiwangi Gupta

    Email: shiwangi.ph19239@inst.ac.in

    Reg. No.: PH19239

    Working Since Jan, 2020

  • Mr. Atul Dev

    Email: atul.ph14220@inst.ac.in

    Reg. No.: PH14220

    Working Since Jan, 2015

  • Mr. Jignesh Mohanbhai Soni

    Email: jignesh.ph19206@inst.ac.in

    Reg. No.: PH19206

    Working Since Aug, 2019

  • Mr. Mohammed Nadim

    Email: nadim.ph16240@inst.ac.in

    Reg. No.: PH16240

    Working Since Jan, 2017

  • Mr. Avinash Chandra Kushwaha

    Email: avinash.ph17210@inst.ac.in

    Reg. No.: PH17210

    Working Since Aug, 2017

PhD Students

  • Mr. Anup Kumar

    Email: anup.iiserm@gmail.com

    Reg. No.: PH13046


  1. Genistein nanoformulation promotes selective apoptosis in oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway: Atul Dev, Mohammed Nadim Sardoiwala, Avinash Chandra Kushwaha,Surajit Karmakar*, Subhasree Roy Choudhury*, (2021) Phytomedicine, 80: 153386. DOI: https://doi.org/10.1016/j.phymed.2020.153386

  2. Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson’s disease via PP2A-EzH2 signaling in vitro and ex vivo: Mohammed Nadim Sardoiwala,Surajit Karmakar, Subhasree Roy Choudhury*, (2020) Carbohydrate Polymers, just accepted: 117435. DOI: https://doi.org/10.1016/j.carbpol.2020.117435

  3. Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models: Anup K. Srivastava, Subhasree Roy Choudhury*,Surajit Karmakar*, (2020) Neuropharmacology, just accepted: -. DOI: https://doi.org/10.1016/j.neuropharm.2020.108372

  4. PRT4165 nanocomposite promoting epigenetic retardation through proteasomal depletion of polycomb in acute myeloid leukemia  : Avinash Chandra Kushwaha, Babita Kaundal, Atul Dev, Anup Kumar Srivastava, Soni Jignesh Mohanbhai, Surajit Karmakar*, and Subhasree Roy Choudhury*, (2020) Applied Materials Today, . DOI: Just accepted

  5. A non-viral nano-delivery system targeting epigenetic methyltransferase EZH2 for precise Acute Myeloid Leukemia therapy.: Babita Kaundal, Avinash Chandra Kushwaha, Anup K Srivasatava, Surajit Karmakar, Subhasree Roy Choudhury*, (2020) Journal of Materials Chemistry B, just accepted: .

  6. Epigenetic Regulation of Bmi1 by Ubiquitination and Proteasomal Degradation Inhibit Bcl 2 in Acute Myeloid Leukemia: Avinash Chandra Kushwaha,Soni Jignesh Mohanbhai,Mohammed Nadim Sardoiwala,Ankur Sood,Surajit Karmakar* and,Subhasree Roy Choudhury*, (2020) ACS Applied Materials and Interfaces, 2020, 12, 23,: 25633–25644.. DOI: https://dx.doi.org/10.1021/acsami.0c06186

  7. Melatonin/Polydopamine Nanostructures for Collective Neuroprotection based Parkinson’s Disease Therapy.: Srivastava, AK, Roy Choudhury S*, Karmakar S*, (2020) Biomaterials Science, . DOI: https://doi.org/10.1039/C9BM01602C

  8. Recuperative Effect of Metformin loaded Polydopamine Nanoformulation promoting EZH2 mediated Proteasomal Degradation of phospho-α-Synuclein in Parkinson's disease model: Md Nadim Sardoiwala ,Anup K Srivastava ,Babita Kaundal ,Surajit Karmakar ,Subhasree Roy Choudhury*, (2020) Nanomedicine: Nanotechnology, Biology, and Medicine, 24: 102088. DOI: 10.1016/j.nano.2019.102088.

  9. κ-carrageenan-C phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring.: Atul Dev,Soni J Mohanbhai,Avinash C. Kushwaha,Mohammed Nadim Sardoiwala ,Subhasree Roy Choudhury* ,Surajit Karmakar*, (2020) Acta Biomaterialia, 109: 121-131. DOI: https://doi.org/10.1016/j.actbio.2020.03.023

  10. Hypericin-Loaded Transferrin Nanoparticles Induce PP2A-Regulated BMI1 Degradation in Colorectal Cancer-Specific Chemo-Photodynamic Therapy: Mohammed Nadim Sardoiwala, Avinash Chandra Kushwaha, Atul Dev, Nishith Shrimali, Prasenjit Guchhait, Surajit Karmakar* , and Subhasree Roy Choudhury*, (2020) ACS Biomater. Sci. Eng., 6: 3139-3153. DOI: https://doi.org/10.1021/acsbiomaterials.9b01844

  11. Near-Infrared Responsive Dopamine/Melatonin-Derived Nanocomposites Abrogating in Situ Amyloid β Nucleation, Propagation, and Ameliorate Neuronal Functions.: Srivastava AK, Roy Choudhury S*, Karmakar S*, (2020) ACS Appl. Mater. Interfaces, 12: 5658-5670. DOI: https://doi.org/10.1021/acsami.9b22214

  12. Paclitaxel nanocrystalline assemblies as a potent Transcatheter arterial chemoembolization (TACE) candidate for unresectable hepatocellular carcinoma.: Dev A, Sood A, Roy Choudhury S, Karmakar S*, (2020) Materials Science & Engineering C, 107: 110315.. DOI: https://doi.org/10.1016/j.msec.2019.110315

  13. Nanoformulation of EPZ011989 attenuates EZH2-c-Myb epigenetic interaction by proteasomal degradation in Acute Myeloid Leukemia.: Kaundal B; Srivastava A; Dev A; Mohanbhai Soni J; Karmakar S; Roy Choudhury S*, (2020) Mol. Pharmaceutics, 2: 604-621. DOI: https://doi.org/10.1021/acs.molpharmaceut.9b01071

  14. Disulfide-Bridged Chitosan-Eudragit S-100 Nanoparticles for Colorectal Cancer.: Sood A, Dev A, Mohanbhai SJ, Shrimali N, Kapasiya M, Kushwaha A, Roy Choudhury S, Guchhait P, Karmakar S*., (2019) ACS Appl. Nano Mater, 2, 10: 6409-6417.. DOI: https://doi.org/10.1021/acsanm.9b01377

  15. Nanostructure Endows Neurotherapeutic Potential in Optogenetics: Current Development and Future Prospects.: Mohammed Nadim Sardoiwala, Anup K. Srivastava, Surajit Karmakar*, Subhasree Roy Choudhury*., (2019) ACS Chem. Neurosci, 10, 8: 3375-3385.. DOI: https://doi.org/10.1021/acschemneuro.9b00246

  16. NIR-responsive Indocyanine green-GenisteinNanoformulation controlling Polycomb epigenetic machinery for efficient Photo-Chemo-Combotherapy of Glioblastoma.: Kaundal B, Srivastava AK, Sardoiwala N Md, Karmakar S, Roy Choudhury S*, (2019) Nanoscale Advances, 1: 2188-2207. DOI: https://doi.org/10.1039/C9NA00212J

  17. New Generation hybrid nanobiocatalysts: The catalysis redefined, In: “Handbook of Nanomaterials for Industrial Applications”: Dev A, Srivastava A, (2018) Elsevier Press, 1st Edition,eBook, .

  18. 1,3βGlucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy.: Singh PK, Srivastava AK, Dev A, Kaundal B, Choudhury SR, (2018) Carbohydr Polym, 180: 365-375. DOI: 10.1016/j.carbpol.2017.10.030

  19. New Insight into Curcumin Tethered Lanthanum Carbonate Nanospheres and Protein Corona Conferring Fluorescence Enhancement based Sensitive Detection of Amyloid-beta Aggregates.Sensors and Actu: Srivastava AK, Dev A, Choudhury SR, (2018) Chemical, 262: 687-695. DOI: 10.1016/j.snb.2018.02.002

  20. Superior bactericidal efficacy of fucose functionalized silver nanoparticles against Pseudomonas aeruginosa PAO1 and prevention of its colonization on urinary catheters.: Bhargava A, Pareek V, Roy Choudhury S, Panwar J, (2018) ACS Applied Materials and Interfaces, 10(35): 29325-29337. DOI: 10.1021/acsami.8b09475

  21. 1,3β Glucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy: Pankaj K. Singh,Anup K. Srivastava,Atul Dev,Babita Kaundal,Subhasree Roy Choudhury* ,Surajit Karmakar*, (2018) CarbohydrPolym, 180: 365-375. DOI: 10.1016/j.carbpol.2017.10.030

  22. Nano-toxicity and Plants. In Nanoscience in Food and Agriculture: Dev A,Srivastava A, (2017) 5: 169-204.

  23. Nutraceutical phycocyanin nanoformulation for efficient drug delivery of paclitaxel in human glioblastoma U87MG cell line.: Agrawal, M., Yadav, S.K., Agrawal, (2017) J Nanopart Res,, 19: 272. DOI: /10.1007/s11051-017-3972-x

  24. Current trends and recent innovations in nanosensors and nanobiosensors: perspective into food and agriculture sector.: Srivastava A, Dev A, (2017) Environ Chem Lett, . DOI: 10.1007/s10311-017-0674-7

  25. Nanomaterial toxicity for plants: Dev A., Srivastava, A.K., (2017) Environ Chem Lett, 1-16. DOI: 10.1007/s10311-017-0667-6

  26. Nanosensors and Nanobiosensors: Current trend and innovation in perspective of Food and Agriculture Sector.: Srivastava A, Dev A, (2017) In Nanoscience in Food and Agriculture, 5: 41-79.

  27. Nanomelatonin triggers superior anticancer functionality in a human malignant glioblastoma cell line.: Yadav KS, Kumar Srivastava A, Dev A, Kaundal B, Roy Choudhury S, (2017) Nanotechnology, 28: 365102. DOI: 10.1088/1361-6528/aa7c76

  28. Facile Synthesis of Large‐Pore Bicontinuous Cubic Mesoporous Silica Nanoparticles for Intracellular Gene Delivery.: Meka AK, Niu Y, Hartono SB, Zhang J, Xiang C, Lin C, Zhang H, Whittaker A, Jack K, Yu M, Yu C, (2016) ChemNanoMat ChemNanoMat, 2: 220–225. DOI: 10.1002/cnma.201600021

  29. Nano-curcumin influences blue light photodynamic therapy for restraining glioblastoma stem cells growth.: Dev A, Srivastava AK, Roy Choudhury S, (2016) RSC Adv., 6: 95165-95168. DOI: 10.1039/C6RA20269A

  30. Shaping Nanoparticles with Hydrophilic Compositions and Hydrophobic Properties as Nanocarriers for Antibiotic Delivery.: Ahmad Nor Y, Niu Y, Zhou L, Xu C, Zhang J, Zhang H, Yu M, Yu C, (2015) ACS Central Science, 1 (6): 328-334. DOI: 10.1021/acscentsci.5b00199

  31. Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles.: Jambhrunkar S, Qu Z, Popat A, Xu C, Yu C, (2014) J Colloid Interface Sci.,, 434: 218-25.. DOI: 10.1016/j.jcis.2014.08.019

  32. Effect of Surface Functionality of Silica Nanoparticles on Cellular Uptake and Cytotoxicity.: Jambhrunkar S, Qu Z, Popat A, Yang J, Noonan O, Acauan L, Nor YA, Yu C, (2014) Mol Pharm, 11(10): 3642-55. DOI: 10.1021/mp500385n

  33. Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake.: Yang Y, Zhang J, Yu M, Mitter N, Yu C, (2014) Journal of Materials Chemistry B, 230: 4929-4934. DOI: 10.1039/C4TB00595C

  34. Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins.: Zhang J, Yu M, Mitter N, Zou J, Yu C., (2014) Small, 10(24): 5068-76. DOI: 10.1002/smll.201401538

  35. N-(4-Hydroxyphenyl) Retinamide Potentiated Anti-Tumor Efficacy of Genistein in Human Ewing’s Sarcoma Xenografts.: Karmakar S, Choudhury SR, Banik NL, Ray SK, (2011) World J Oncol, 2: 53-63. PMID:21822457. DOI: 10.4021/wjon301w

  36. Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cell: Nishant Mohan, Naren L. Banik, and Swapan K. Ray, (2009) Brain Res, 1283,: 155-166. PMID: 19505441.. DOI: 10.1016/j.brainres.2009.05.097

  37. Curcumin activated multiple molecular mechanisms for apoptosis in human glioblastoma T98 cells. Annual Meeting of American Society for Neurochemistry at Madison: Wisconsin, June 25-29, Saha A, Das A, Banik NL, Ray SK, (2005) .

  1. Recuperative Effect of Metformin loaded Polydopamine Nanoformulation promoting EZH2 mediated Proteasomal Degradation of phospho-α-Synuclein in Parkinson's disease model: Md Nadim Sardoiwala ,Anup K Srivastava ,Babita Kaundal ,Surajit Karmakar ,Subhasree Roy Choudhury*, (2020) Nanomedicine: Nanotechnology, Biology, and Medicine, 24: 102088. DOI: 10.1016/j.nano.2019.102088.

  1. Nanobiosensors and Its Application in Agriculture and Food. Nanopharmaceuticals,: Sardoiwala N Md, Srivastava AK, Roy Choudhury S, Karmakar S*., (2020) 21st Century Nanoscience – A Handbook; Nanopharmaceuticals, Nanomedicine, and Food Nanoscience;Taylor and Francis Group, 1st Ed, Volume 8: 344. DOI: https://doi.org/10.1201/9780429351587

  1. Human glioblastoma T98G cells xenografted in athymic nude mice overwhelmingly committed after treatment with all-trans retinoic acid and taxol. European Winter Oncology Conference,: at Edinburgh, United Kingdom. Ray SK, Das A, Banik NL, Patel SJ, (2005) .

  2. A potential role for calpain in pathogenesis of kainic acid-induced epileptic seizures in sprague-dawley rats. MUSC Student Research Day., SC, USA.: Fry P, Matzelle D, Banik NL, Ray SK, (2005) .

  3. A combination therapy for enhancement of apoptosis in human malignant glioblastoma T98G and U87MG cells xenografted in nude mice. International Symposium on Translational Research: Apoptosis: Banik NL, Patel SJ, and Ray SK, (2005) .

  4. Dexamethasone decreases while acetazolomide increases temozolomide induced apoptosis in human glioblastoma cells. Annual Meeting of American Society for Neurochemistry at Madison, Wisconsin: Das A, Saha A, Banik NL, Ray SK, (2005) .

  5. All-trans retinoic acid decreased telomerase activity and increased IFN-γ and taxol induced apoptosis in human glioblastoma T98G cells.: SFN Annual Meeting. Das A, Banik NL, Patel SJ, Ray SK, (2004) .

  6. Activation of proteolytic mechanisms in apoptosis of human malignant neuroblastoma SH-SY5Y cells exposed to diallyl disulphide (DADS).: MUSC Student Research Day. Yallapragada AV, Das A, Banik NL, Patel SJ, Ray SK, (2004) .

  7. Occurrence of an antineoplastic compound (CSS-ANF) from the skin of the snake head fish Channa striatus, Linn.: XXXVI Annual Conference of the Indian Pharmacological Society. Gomes A (, (2003) .

Fundings

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  • 2003

    PhD in Physiology

    University of Calcutta, India

  • 1999

    MSc in Physiology

    University of Calcutta, India

  • 1997

    BSc (Physiology (Honors), Zoology, Chemistry)

    University of Calcutta, India

  • Post Doctoral Fellow:The Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, St Lucia, QLD 4072, Australia (January 2012 to January 2014 )

  • Research Associate:Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA (January 2010 to January 2011 )

  • Postdoctoral fellow:Department of Pathology, Microbiology and Immunology and Chemical Engineering, University of South Carolina, Columbia, SC 29209, USA (January 2008 to January 2010 )

  • Postdoctoral fellow at Department of Neurosciences:Medical University of South Carolina, Charleston, SC 29425, USA (January 2004 to January 2007 )

Awards & Honours

  •  New Staff Development Grant: University of Queensland, 2013

  • Young Investigator Award, American Society for Neurochemistry, 2005

  • Senior Research Fellow, ICMR, New Delhi, India, 2002-2004


Professional Recognitions

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