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Dr. Subhasree Roy Choudhury

Scientist-C

Development of target specific nanotherapeutics for epigenetic regulation of cancer. Chemoprevention and mechanism of action of drug/siRNA loaded nanoparticle mediated therapy for leukemia, neuroblastoma and glioblastoma. New drug development from natural products and combination therapy against cancer. Development and application of high-throughput functional gene-based screening for cancer. Multiple retrovirus and lentivirus mediated gene delivery for target validation and functional implication in cancer.

CONTACT INFORMATION :

Research Interest

  • Development of target specific nanotherapeutics for epigenetic regulation of cancer. Chemoprevention and mechanism of action of drug/siRNA loaded nanoparticle mediated therapy for leukemia, neuroblastoma and glioblastoma. New drug development from natural products and combination therapy against cancer. Development and application of high-throughput functional gene-based screening for cancer. Multiple retrovirus and lentivirus mediated gene delivery for target validation and functional implication in cancer.

Research Highlights

  • Dr. Subhasree Roy Choudhury’s research group works on neuroprotective efficacy of nature inspired biocompatible polydopamine nanocarrier for metformin delivery (Met encapsulated PDANPs) by crossing blood brain barrier in in vitro, 3D and in vivo experimental Parkinson’s disease models. The neuroprotective mechanism proved novel interaction of epigenetic regulator EZH2 mediated ubiquitination and proteasomal degradation of aggregated pSer129 α-Syn. This study divulges the neuroprotective role of Met loaded PDANPs by reversing the neurochemical deficits by confirming an epigenetic mediated nanotherapeutic approach for the PD prevention.

    More details: Nanomedicine 2020;24:102088. doi: 10.1016/j.nano.2019.102088. 

  • Dr. Subhasree Roy Choudhury and group have shown targeted photodynamic therapy (PDT) with potential photosessitizer nanocomposite inducing PP2A-mediated BMI1 ubiquitination/degradation demonstrating an epigenetic driven nanotherapeutic approach in colorectal cancer treatment.

     

    More details: ACS Biomater. Sci. Eng. 2020, 6, 5, 3139–3153. https://doi.org/10.1021/acsbiomaterials.9b01844

  • Dr. Subhasree Roy Choudhury and group have recently shown that Polycomb protein Bmi1 is associated with advanced prognosis of acute myeloid leukemia (AML). Polyethylenimine (PEI)-stabilized Bmi1 siRNA-entrapped human serum albumin (HSA) nanocarriers (PEI@HSANCs) were used to protect siRNA from degradation and for epigenetic regulation-based AML therapy. Nanoform increased the transfection efficiency of Bmi1 siRNA through caveolae-mediated endocytosis and enhanced Bax translocation into the mitochondria, enhanced caspase 3-mediated apoptosisand inhibited Bcl2. The molecular analysis reveals the downregulation of polycomb proteins, Bmi1 and EzH2, along with inhibition of H3K27me3 and H2AK119ub1 through ubiquitin-mediated degradation of Bmi1, which is reversed by a proteasome inhibitor. Further mechanistic studies by Chromatin immunoprecipitation (ChIP) assay established a crucial role of transcription factor, C-Myb and Bmi1, as its direct targets for maintenance and progression of AML. Decreased leukemic stem cells marker (CD45+) and an increase in the myeloid differentiating marker expression (CD11b+) in the bone marrow,withdrawal of epigenetic repression through ubiquitin proteasomal pathway potentiating a novel antileukemic therapy were established in in vivo AML xenograft model.

    More details: ACS Appl. Mater. Interfaces 2020, 12, 23, 25633–25644. https://doi.org/10.1021/acsami.0c06186

     

PhD Students

  • Ms. Babita Kaundal

    Email: babita.ph16209@inst.ac.in

    Reg. No.: Ph16209

    Working Since Aug, 2016

  • Mr. Mohammed Nadim

    Email: nadim.ph16240@inst.ac.in

    Reg. No.: PH16240

    Working Since Jan, 2017

  • Mr. Avinash Chandra Kushwaha

    Email: avinash.ph17210@inst.ac.in

    Reg. No.: PH17210

    Working Since Aug, 2017

  • Mr. MAHENDRAN J.

    Email: mahendran.ph20213@inst.ac.in

    Reg. No.: PH20213

    Working Since Aug, 2020

  • MS. BABITA BHATT

    Email: babita.ph20212@inst.ac.in

    Reg. No.: PH20212

    Working Since Aug, 2020

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  1. Hytrin loaded polydopamine-serotonin nanohybrid induces IDH2 mediated neuroprotective effect to alleviate Parkinson's disease: Mohammed Nadim Sardoiwala,Soni JIgnesh Mohanbhai ,Surajit Karmakar,Subhasree Roy Choudhury *, (2022) Materials Science and Engineering: C, just accepted: -. DOI: https://doi.org/10.1016/j.msec.2021.112602

  2. Coupled catalytic dephosphorylation and complex phosphate ion-exchange in networked hierarchical lanthanum carbonate grafted asymmetric bio- composite membrane: Anup K. Srivastava,Babita Kaundal ,Mohammed Nadim Sardoiwala,Subhasree Roy Choudhury,Surajit Karmakar*, (2022) Journal of Colloid and Interface Science, 2022 Jan 15;606(Pt 2):: 2024-2037. DOI: https://doi.org/10.1016/j.jcis.2021.09.173

  3. Alpha-ketoglutarate decorated iron oxide-gold core-shell nanoparticles for active mitochondrial targeting and radiosensitization enhancement in hepatocellular carcinoma: Ankur Sood,Atul Dev ,Mohammed Nadim Sardoiwala , Subhasree Roy Choudhury, Shubhra Chaturvedi,Anil Kumar Mishra,Surajit Karmakar, (2021) Materials Science and Engineering: C, 129, 2021,: 112394. DOI: https://doi.org/10.1016/j.msec.2021.112394

  4. Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model: Mohanbhai Jignesh Soni, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury,Shyam Sunder Sharma, Surajit Karmakar, (2021) Materials Science and Engineering: C, 124, 2021: 112038. DOI: https://doi.org/10.1016/j.msec.2021.112038

  5. Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models: Anup K. Srivastava, Subhasree Roy Choudhury*,Surajit Karmakar*, (2021) Neuropharmacology, 194,2021: 108372. DOI: https://doi.org/10.1016/j.neuropharm.2020.108372

  6. Pre-coating of protein modulate patterns of corona formation, physiological stability and cytotoxicity of Silver nanoparticles: Arpit Bhargava,Atul Dev,Soni Jignesh Mohanbhai ,Vikram Pareek,Navin Jain ,Subhasree Roy Choudhury,Jitendra Panwar ,Surajit Karmakar, (2021) Stoten, 144797: . DOI: https://doi.org/10.1016/j.scitotenv.2020.144797

  7. Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson’s disease via PP2A-EzH2 signaling in vitro and ex vivo: Mohammed Nadim Sardoiwala,Surajit Karmakar, Subhasree Roy Choudhury*, (2021) Carbohydrate Polymers, 254: 117435. DOI: https://doi.org/10.1016/j.carbpol.2020.117435

  8. Genistein nanoformulation promotes selective apoptosis in oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway: Atul Dev, Mohammed Nadim Sardoiwala, Avinash Chandra Kushwaha,Surajit Karmakar*, Subhasree Roy Choudhury*, (2021) Phytomedicine, 80: 153386. DOI: https://doi.org/10.1016/j.phymed.2020.153386

  9. PRT4165 nanocomposite promoting epigenetic retardation through proteasomal depletion of polycomb in acute myeloid leukemia  : Avinash Chandra Kushwaha, Babita Kaundal, Atul Dev, Anup Kumar Srivastava, Soni Jignesh Mohanbhai, Surajit Karmakar*, and Subhasree Roy Choudhury*, (2020) Applied Materials Today, . DOI: Just accepted

  10. A non-viral nano-delivery system targeting epigenetic methyltransferase EZH2 for precise Acute Myeloid Leukemia therapy.: Babita Kaundal, Avinash Chandra Kushwaha, Anup K Srivasatava, Surajit Karmakar, Subhasree Roy Choudhury*, (2020) Journal of Materials Chemistry B, just accepted: .

  11. Epigenetic Regulation of Bmi1 by Ubiquitination and Proteasomal Degradation Inhibit Bcl 2 in Acute Myeloid Leukemia: Avinash Chandra Kushwaha,Soni Jignesh Mohanbhai,Mohammed Nadim Sardoiwala,Ankur Sood,Surajit Karmakar* and,Subhasree Roy Choudhury*, (2020) ACS Applied Materials and Interfaces, 2020, 12, 23,: 25633–25644.. DOI: https://dx.doi.org/10.1021/acsami.0c06186

  12. Melatonin/Polydopamine Nanostructures for Collective Neuroprotection based Parkinson’s Disease Therapy.: Srivastava, AK, Roy Choudhury S*, Karmakar S*, (2020) Biomaterials Science, . DOI: https://doi.org/10.1039/C9BM01602C

  13. Recuperative Effect of Metformin loaded Polydopamine Nanoformulation promoting EZH2 mediated Proteasomal Degradation of phospho-α-Synuclein in Parkinson's disease model: Md Nadim Sardoiwala ,Anup K Srivastava ,Babita Kaundal ,Surajit Karmakar ,Subhasree Roy Choudhury*, (2020) Nanomedicine: Nanotechnology, Biology, and Medicine, 24: 102088. DOI: 10.1016/j.nano.2019.102088.

  14. κ-carrageenan-C phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring.: Atul Dev,Soni J Mohanbhai,Avinash C. Kushwaha,Mohammed Nadim Sardoiwala ,Subhasree Roy Choudhury* ,Surajit Karmakar*, (2020) Acta Biomaterialia, 109: 121-131. DOI: https://doi.org/10.1016/j.actbio.2020.03.023

  15. Hypericin-Loaded Transferrin Nanoparticles Induce PP2A-Regulated BMI1 Degradation in Colorectal Cancer-Specific Chemo-Photodynamic Therapy: Mohammed Nadim Sardoiwala, Avinash Chandra Kushwaha, Atul Dev, Nishith Shrimali, Prasenjit Guchhait, Surajit Karmakar* , and Subhasree Roy Choudhury*, (2020) ACS Biomater. Sci. Eng., 6: 3139-3153. DOI: https://doi.org/10.1021/acsbiomaterials.9b01844

  16. Near-Infrared Responsive Dopamine/Melatonin-Derived Nanocomposites Abrogating in Situ Amyloid β Nucleation, Propagation, and Ameliorate Neuronal Functions.: Srivastava AK, Roy Choudhury S*, Karmakar S*, (2020) ACS Appl. Mater. Interfaces, 12: 5658-5670. DOI: https://doi.org/10.1021/acsami.9b22214

  17. Paclitaxel nanocrystalline assemblies as a potent Transcatheter arterial chemoembolization (TACE) candidate for unresectable hepatocellular carcinoma.: Dev A, Sood A, Roy Choudhury S, Karmakar S*, (2020) Materials Science & Engineering C, 107: 110315.. DOI: https://doi.org/10.1016/j.msec.2019.110315

  18. Nanoformulation of EPZ011989 attenuates EZH2-c-Myb epigenetic interaction by proteasomal degradation in Acute Myeloid Leukemia.: Kaundal B; Srivastava A; Dev A; Mohanbhai Soni J; Karmakar S; Roy Choudhury S*, (2020) Mol. Pharmaceutics, 2: 604-621. DOI: https://doi.org/10.1021/acs.molpharmaceut.9b01071

  19. NIR-responsive Indocyanine green-GenisteinNanoformulation controlling Polycomb epigenetic machinery for efficient Photo-Chemo-Combotherapy of Glioblastoma.: Kaundal B, Srivastava AK, Sardoiwala N Md, Karmakar S, Roy Choudhury S*, (2019) Nanoscale Advances, 1: 2188-2207. DOI: https://doi.org/10.1039/C9NA00212J

  20. Nanostructure Endows Neurotherapeutic Potential in Optogenetics: Current Development and Future Prospects.: Mohammed Nadim Sardoiwala, Anup K. Srivastava, Surajit Karmakar*, Subhasree Roy Choudhury*., (2019) ACS Chem. Neurosci, 10, 8: 3375-3385.. DOI: https://doi.org/10.1021/acschemneuro.9b00246

  21. Disulfide-Bridged Chitosan-Eudragit S-100 Nanoparticles for Colorectal Cancer.: Sood A, Dev A, Mohanbhai SJ, Shrimali N, Kapasiya M, Kushwaha A, Roy Choudhury S, Guchhait P, Karmakar S*., (2019) ACS Appl. Nano Mater, 2, 10: 6409-6417.. DOI: https://doi.org/10.1021/acsanm.9b01377

  22. Development of engineered nanoparticles expediting diagnostic and therapeutic applications across blood brain barrier.: Mohammed Nadim Sardoiwala Babita Kaundal and Subhasree Roy Choudhury*, (2018) Handbook of Nanomaterials for Industrial Applications, Elsevier Press, 2018: 696-709. DOI: https://doi.org/10.1016/B978-0-12-813351-4.00038-9

  23. Superior Bactericidal Efficacy of Fucose-Functionalized Silver Nanoparticles against Pseudomonas aeruginosa PAO1 and Prevention of Its Colonization on Urinary Catheters.: Bhargava A, Pareek V,Panwar J, Karmakar S., (2018) ACS Appl Mater Interfaces, 10(35): 29325-29337. DOI: 10.1021/acsami.8b09475

  24. 1,3β Glucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy: Pankaj K. Singh,Anup K. Srivastava,Atul Dev,Babita Kaundal,Subhasree Roy Choudhury* ,Surajit Karmakar*, (2018) CarbohydrPolym, 180: 365-375. DOI: 10.1016/j.carbpol.2017.10.030

  25. New Insight into Curcumin Tethered Lanthanum Carbonate Nanospheres and Protein Corona Conferring Fluorescence Enhancement based Sensitive Detection of Amyloid-beta: Srivastava AK, Dev A, Karmakar S, (2018) Sensors and Actuators B: Chemical, 262: 687-695. DOI: 10.1016/j.snb.2018.02.002

  26. Nanomelatonin triggers superior anticancer functionality in a human malignant glioblastoma cell line.: Kumar Yadav S, Kumar Srivastava A, Dev A, Kaundal B, Karmakar S*., (2017) Nanotechnology, 28: 365102. DOI: 10.1088/1361-6528/aa7c76

  27. Toxic impact of nanomaterials on microbes, plants and animals.: Sardoiwala MN, Kaundal B, (2017) Environ Chem Lett., 16: 147-160. DOI: 10.1007/s10311-017-0672-9

  28. Nanomaterial toxicity in Microbes, Plants and Animals.: Kaundal B, Dalai S, (2017) Nanoscience in Food and Agriculture, (Springer Nature publisher)., 5: 243-266. DOI: 10.1016/j.bbrc.2010.04.156

  29. Nano-curcumin influences blue light photodynamic therapy for restraining glioblastoma stem cells growth: Dev A, Srivastava AK, Karmakar S, (2016) RSC Adv., 6: 95165-95168. DOI: 10.1039/C6RA20269A

  30. N-(4-Hydroxyphenyl) Retinamide Potentiated Anti-Tumor Efficacy of Genistein in Human Ewing’s Sarcoma Xenografts.: Karmakar S, Choudhury SR, Banik NL, Ray SK, (2011) World J Oncol, 2: 53-63. PMID:21822457. DOI: 10.4021/wjon301w

  31. Valproic Acid Induced Differentiation and Potentiated Efficacy of Taxol and Nanotaxol for Controlling Growth of Human Glioblastoma LN18 and T98G Cells: Karmakar S, Banik NL, Ray SK, (2011) Neurochem Res, 36: 2292-305. PMID: 21786169.. DOI: 10.1007/s11064-011-0554-7

  32. Epigallocathechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells: Balasubramanian S, Chew Yap, Han B, Marquez V, Eckert RL, (2011) Carcinogenesis, 32: 1525-32. PMID: 21798853.. DOI: 10.1093/carcin/bgr171

  33. Induction of Mitochondrial Pathways and Endoplasmic Reticulum Stress for Increasing Apoptosis in Ectopic and Orthotopic Neuroblastoma Xenografts.: Karmakar S, Banik NL, Ray SK, (2011) J Cancer Ther, 2: 77-90,PMID:22468231. DOI: 10.4236/jct.2011.22009

  34. Activation of Multiple Molecular Mechanisms for Increasing Apoptosis in Human Glioblastoma T98G Xenograft.: Karmakar S, Banik NL, Ray SK, (2010) J Cancer Sci Ther, 2: 107-113, PMID: 21666767. DOI: 10.4172/1948-5956.1000033

  35. Down regulation of angiogenic and survival factors increased apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification.: Karmakar S, Banik NL, Ray SK, (2010) Investigational New Drugs, 28: 812-24. PMID: 19777160.. DOI: 10.1007/s10637-009-9324-7

  36. Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts: Karmakar S, Banik NL, Ray SK, (2009) Neuroscience, 163: 286-295. PMID: 19540315.. DOI: 10.1016/j.neuroscience.2009.06.037

  37. Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways.: Karmakar S, Davis KA, Deeconda A, Banik NL, Ray SK, (2009) BBRC, 388: 705-710,PMID: 19695221.. DOI: 10.1016/j.bbrc.2009.08.071

  38. Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways.: Karmakar S, Davis KA, Deeconda A, Banik NL, Ray SK, (2009) BBRC, 388: 705-710,PMID: 19695221.. DOI: 10.1016/j.bbrc.2009.08.071

  39. Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cell: Nishant Mohan, Naren L. Banik, and Swapan K. Ray, (2009) Brain Res, 1283,: 155-166. PMID: 19505441.. DOI: 10.1016/j.brainres.2009.05.097

  40. A heat stable protein toxin (drCT-I) from the Indian Viper (Daboia russelli russelli) venom having antiproliferative, cytotoxic and apoptotic activities.: A Gomes, A Saha, R Mishra, B Giri, AK Biswas, A Debnath, A Gomes, (2007) Toxicon, 49(1): 46-56, PMID: 17055549.. DOI: 10.1016/j.toxicon.2006.09.009

  41. Purification, crystallization and preliminary X-ray structural studies of a 7.2 kDa cytotoxin isolated from the venom of Daboia russelli russelli of the Viperidae family.: Aparna Gomes, Antony Gomes, Jiban K. Dattagupta,Udayaditya Sen, (2006) Acta Cryst., F62: 292–294. PMID: 16511326.. DOI: 10.1107/S1744309106005963

  42. Hepatoprotective and Immunomodulatory properties Of Tinospora cordifolia in CCL4 intoxicated mature albino rats.: B.Bishayi,S.Ghose,M.Sengupta, (2002) The Journal Of Toxicological Science, 27(3): 139-146. PMID: 12238138.. DOI: 10.2131/jts.27.139

  1. Recuperative Effect of Metformin loaded Polydopamine Nanoformulation promoting EZH2 mediated Proteasomal Degradation of phospho-α-Synuclein in Parkinson's disease model: Md Nadim Sardoiwala ,Anup K Srivastava ,Babita Kaundal ,Surajit Karmakar ,Subhasree Roy Choudhury*, (2020) Nanomedicine: Nanotechnology, Biology, and Medicine, 24: 102088. DOI: 10.1016/j.nano.2019.102088.

  1. Nanobiosensors and Its Application in Agriculture and Food. Nanopharmaceuticals,: Sardoiwala N Md, Srivastava AK, Roy Choudhury S, Karmakar S*., (2020) 21st Century Nanoscience – A Handbook; Nanopharmaceuticals, Nanomedicine, and Food Nanoscience;Taylor and Francis Group, 1st Ed, Volume 8: 344. DOI: https://doi.org/10.1201/9780429351587

  2. Role of angiogenesis in the pathogenesis of glioblastoma and antiangiogenic therapies for controlling glioblastoma. In Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeut: Karmakar S, Banik NL, Ray SK, (2010) Publisher: Springer; 1 edition,, 217-241 , ISBN-978-1-4419-0409-6..

  1. Functional validation of Myb target genes in myeloid leukaemic transformation. New directions in leukemia research.: March 30-April 2nd, Noosa, QLD, Australia. Gonda Tom, (2014) .

  2. c-Myb interaction with histone acetyltransferase p300 regulates its transcriptional activities in human leukaemic cells.: New directions in leukemia research. March 30-April 2nd, Noosa, QLD, Australia. Ding Jianmin, Cao Lu, and Gonda Tom, (2014) .

  3. Synergistic efficacy of HA14-1 and apigenin in inhibiting angiogenic factors and increasing apoptosis in neuroblastoma cells.: Frontiers in Neuroscience Conference. March 05 - 07, Atlanta, USA Davis KA, Karmakar S, Banik NL and Ray SK, (2010) .

  4. Combination of sorafenib and genistein inhibits angiogenesis and triggers multiple molecular mechanisms for apoptosis in human malignant neuroblastoma SK-N-DZ and SH-SY5Y cell lines presented: Karmakar S, Banik NL, Ray SK, (2009) .

  5. Small Molecule Inhibitor of Bcl-2 Enhances Efficacy of Genistein for Apoptosis in Neuroblastoma SH-SY5Y and SK-N-BE2 Cell lines.: Mohan N, Karmakar S, Banik NL , Ray SK, (2009) .

  6. Combination of valproic acid and taxol or nanotaxol effectively inhibited angiogenic factors and increased apoptosis in glioblastoma U87MG cells in culture and xenografts in nude mice.: Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 Karmakar S, Banik NL, Ray SK, (2009) .

  7. Activation of both extrinsic and intrinsic pathways of apoptosis in human neuroblastoma SH-SY5Y cells in culture as well as in xenografts in athymic nude mice.: Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 Karmakar S, Banik NL, Ray SK, (2009) .

  8. Combination of N-(4-hydroxyphenyl) retinamide and genistein increases apoptosis in Ewing’s sarcoma SK-N-MC cells in culture and xenografts in athymic nude mice.: Presented at the 100th AACR Annual Meeting Denver, CO, April 18-22, Karmakar S, Tomlinson S, Banik NL, Ray SK, (2009) .

  9. Combination of Bcl-2 inhibitor and apigenin activated extrinsic and intrinsic pathways of apoptosis in neuroblastoma SK-N-DZ cells.: Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11, Davis K, Karmakar S, Deeconda A, Banik NL, Ray SK, (2009) .

  10. Combination of valproic acid and taxol or nanotaxol induced differentiation and apoptosis in glioblastoma LN18 and T98G cells presented at the 40th Annual ASN Meeting,: Charleston, SC - March 7-11 Karmakar S, Banik NL, Ray SK, (2009) .

  11. A new protein toxin (drCT1) from Dabuia russellii venom having antiproliferative and apoptogenic activity in15th World Congress on Animal,: Plant & Microbial Toxins, International Society on Toxinology, Glasgow, UK. July 27. Dasgupta SC, Saha A, Giri B, Gomes A, (2006) .

  12. Structure and functional characterization of a heat stable antineoplastic protein toxin (Toxin CM28) from Russells viper venom.: 37th Annual Conference of the Indian Pharmacological Society, Kolkata, January 14-16. Gomes A, (2005) .

  13. Antineoplastic protein toxin (Toxin CM28) from Vipera russelli russelli venom.: 38th Annual Conference of the Indian Pharmacological Society, Chennai, December 28-30. Gomes A, (2005) .

  14. Pharmacological characterization of a heat stable protein toxin (Toxin CM 28) from Russells viper venom CM 28) from Russells viper venom.: 36th Annual Conference of the Indian Pharmacological Society, Delhi, December, 5-7. Gomes A, (2003) .

  15. Hepatoprotective, immunostimulatory and antioxidant activities of Tinospora cordifolia in CCL4 intoxicated mature albino rats. XIII Annual Conference of the Physiological Society of India,: Kolkata, February 23-24. Bishayi B, (2002) .

Fundings

  • Targeted nanotherapy controlling epigenetic regulation of pediatric solid tumor 3 years, ICMR
    Funding Amount: 47 Lakhs
    PI: Dr. Subhasree Roy Choudhury Co-PI: Prof. Surajit Karmakar
  • Nanotherapy for controlling epigenetic regulation by polycomb in Myb mediated leukemia 3 years, SERB DST
    Funding Amount: 29 Lakhs
    PI: Dr. Subhasree Roy Choudhury
  • Identification of Polycomb and c-Myb signalling and their targeted nanotherapy in leukemogenesis 3 years, DBT
    Funding Amount: 33.04 Lakhs
    PI: Dr. Subhasree Roy Choudhury Co-PI: Prof. Surajit Karmakar
  • Development of Fluorescence and NIR sensitive nanoplatform for imaging and therapy of brain tumors 3 years, DHR
    Funding Amount: 49 Lakhs
    Role PI: Prof. Surajit Karmakar Role Co-PI: Dr. Subhasree Roy Choudhury
  • Controlling Diabetic Retinopathy (DR) through novel dopamine-melatonin combination nano therapy. 3 years, DBT
    Funding Amount: 59 Lakhs
    Role PI: Prof. Surajit Karmakar Role Co-PI: Dr. Subhasree Roy Choudhury

  • 2007

    Ph.D

    University of Calcutta, India (Subject: Physiology; awarded 2009)

  • 2002

    SLET,GATE

    Qualified

  • 2001

    M.Sc

    University of Calcutta, India (Subject: Physiology)

  • 1999

    B.Sc

    University of Calcutta, India (Subject: Physiology) (Honors), Chemistry, Zoology.

  • Post Doctoral Fellow:The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, QLD 4102,, Australia (April 2012 to June 2014 )

  • Post Doctoral Fellow:Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201,, USA (March 2010 to October 2011 )

  • Post Doctoral Fellow:Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC 29209,, USA (March 2008 to March 2010 )

  • Post Doctoral Fellow:Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425,, USA. (November 2007 to January 2008 )

Awards & Honours

  • Awarded Gold Medal by University of Calcutta for securing the 1st Class 1st rank in M.Sc Physiology in 2001.

  • Awarded with Dr. D.N. Mallick Memorial Gold Medal by the Physiological Society of India for securing the 1st Class 1st rank in M.Sc Physiology in 2001.

  • Awarded with Prof. A. K. Mukherjee Memorial Cup by the 6th Annual Scientific Meet Committee, Calcutta in B.Sc examination in Physiology in 1999.

  • Awarded National Scholarship by the West Bengal Board of Secondary Education in Madhyamik examination in 1994.

  • Awarded Junior Research Fellowship and Senior Research Fellowship by UGC.


Professional Recognitions

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