Our research thrusts is to engineering delivery systems for poorly water soluble drugs towards therapeutic clinical applications primarily, against neglected infectious diseases (Visceral Leishmaniasis). We focus on the development of nanomedicines based on biological nanomaterials with considerable priority on interface between in vitro and in vivo studies and how logically-designed and engineered drug delivery systems can be translated into clinically-effective therapeutics.
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Nanodiagnostics in Leishmaniasis: A New Frontier for Early Elimination: Mallikarjuna Rao Gedda, Prasoon Madhukar, Ashish Shukla, Shyam Lal Mudavath, Onkar Nath Srivastava, Om Prakash Singh and Shyam Sundar, (2020) WIREs Nanomedicine and Nanobiotechnology, Accepted: 1-22. DOI: 10.1002/wnan.1675
Recuperating the biopharmaceutical aspects of amphotericin B and paromomycin using a chitosan functionalized nanocarrier via oral route for enhanced anti-leishmanial activity: Shabi Parvez, Ganesh Yadagiri, Archana Karole, Om Prakash Singh, Anurag Verma, Shyam Sundar and Shyam Lal Mudavath*, (2020) Front. Cell. Infect. Microbiol., . DOI: 10.3389/fcimb.2020.570573
Formulation, characterization, and in vitro anti-leishmanial evaluation of amphotericin b loaded solid lipid nanoparticles coated with vitamin B12-stearic acid conjugate: Aakriti Singh‡, Ganesh Yadagiri‡, Shabi Parvez, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath*, (2020) Materials Science & Engineering C, 117: 111279. DOI: 10.1016/j.msec.2020.111279
Evaluation of Safety and Antileishmanial efficacy of Amine Functionalized Carbon-based Composite Nanoparticle appended with Amphotericin B: An In vitro and Preclinical Study: Mallikarjuna Rao Gedda,Prasoon Madhukar,Alok Kumar Vishwakarm,Vimal Verma,Anurag Kumar Kushwaha,Ganesh Yadagiri,Shyam Lal Mudavath,Om Prakash Singh,Onkar Nath Srivastava,Shyam Sundar, (2020) Front. Chem., . DOI: https://doi.org/10.3389/fchem.2020.00510
Improvising anti-leishmanial activity of Amphotericin B and Paromomycin using co-delivery in D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) tailored Nano-lipid carrier system: Shabi Parvez, Ganesh Yadagiri, Aakriti Singh, Archana Karole, Om Prakash Singh, Shyam Sundar,Shyam Lal Mudavath*, (2020) Chemistry and Physics of Lipids, 231: 104946. DOI: 10.1016/j.chemphyslip.2020.104946
Sensible graphene oxide differentiates macrophages and Leishmania: A Bio-nano interplay in attenuating intracellular parasite: Aakriti Singh‡, Sandeep Sharma‡, Ganesh Yadagiri, Shabi Parvez, Nikhil Koratkar, Om Prakash Singh, Shyam Sundar, Vijayakumar Shanmugam* and Shyam Lal Mudavath*, (2020) RSC Advances, 10: 27502–27511. DOI: DOI: 10.1039/d0ra04266h
Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: An effective oral combination against experimental murine visceral leishmaniasis: Shabi Parvez‡, Ganesh Yadagiri‡, Mallikarjuna Rao Gedda, Aakriti Singh, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath*, (2020) Scientific Reports, 10: 12243. DOI: https://doi.org/10.1038/s41598-020-69276-5
Enkephalins as a therapeutic intervention for visceral leishmaniasis: Ganesh Yadagiri,Shyam Lal Mudavath*, (2020) Medical Hypotheses, 144: 109956. DOI: doi.org/10.1016/j.mehy.2020.109956
Envisioning the innovations in nanomedicine to combat visceral leishmaniasis: for future theranostic application: Om Prakash Singh, Mallikarjuna Rao Gedda, Shyam Lal Mudavath, Onkar Nath Srivastava, Shyam Sundar, (2019) Nanomedicine, 14: 1911-1927. DOI: 10.2217/nnm-2018-0448
Mannose-conjugated curcumin-chitosan nanoparticles: Efficacy and toxicity assessments against Leishmania donovani: Chaubey P, Mishra B, Patel RR, Chaurasia S, Sundar S, Suvarna V, Monteiro M, (2018) Int J Biol Macromol, 111: 109-120. DOI: 10.1016/j.ijbiomac.2017.12.143
Galactosylated Chitosan for Enhanced and Efficient Antimicrobial and Antileishmanial Activities: A Novel Approach: Niraj Kumar Vishwakarma, Vijay Kumar Patel, Ravi Kumar, Tanu Gupta, Kalyan Ramesh, Karun Jana, P. K. Dutta, Pralay Maiti, Nira Mishra, (2015) Asian Chitin J, 11: 11-18. DOI: NA
Characterization and evaluation of amine modified graphene Amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies: Talat M, Rai M, Srivastava ON, Sundar S, (2014) Drug Design, Development and Therapy, 8: 1235-47. DOI: 10.2147/DDDT.S63994
In vivo assessment of antileishmanial property of 4-(4, 4, 8-Trimethyl 7-oxo-3-oxabicyclo [3.3.1] non-2-yl)-benzoic acid methyl ester, an oxabicyclo [3.3.1] nonanones, in hamster model: Prakash Saudagar, Pipas Saha, Anil K. Saikia,Vikash Kumar Dubey,Shyam Sundar, (2014) Letters in Drug Design & Discovery, 11: 937-939. DOI: 10.2174/1570180811666140423203826
Comparative Evaluation of Blood and Serum Samples in Rapid Immunochromatographic Tests for Visceral Leishmaniasis: Kumar D, Khanal B, Tiwary P, Tiwary NK, Singh R, Koirala K, Boelaert M, Rijal S, Sundar S., (2013) J Clin Microbiol., 51(12): 3955-9.. DOI: 10.1128/JCM.01232-13
Oxabicyclo derivatives as novel antileishmanial compounds: Prakash Saudagar, Vikash Kumar Dubey, Anil Kumar Saikia, Pipas Saha, Shyam Lal Mudavath and Shyam Sundar, (2013) 863/KOL/2013 (Indian Patent), NA: NA. DOI: NA
Bioimmunotherapy with Recombinant Mouse Granulocyte-Macrophage Colony-Stimulating Factor (Rm GM-CSF) and Melatonin against Experimental Visceral Leishmaniasis: Ganesh Yadagiri, Om Prakash Singh, Shyam Sundar,Shyam Lal Mudavath*, (2020) SSRN, . DOI: https://ssrn.com/abstract=3534231
An oral formulation of Amphotericin B for the treatment of visceral Leishmaniasis: f-Gr-AmB: M Talat, M Rai, ON Srivastava, S Sundar, (2016) International Journal Of Infectious Diseases, 45: 3067. DOI: 10.1016/j.ijid.2016.02.790
Amine modified graphene mediated drug delivery of Amphotericin B for the treatment of visceral leishmaniasis: M. Rai, M. Talat, O.N. Srivastava, S. Sundar, (2014) International Journal of Infectious Diseases, 21S: 1–460. DOI: 10.1016/j.ijid.2014.03.753
Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Andhra Pradesh, India
Osmania University, Hyderabad, Andhra Pradesh, India
Scientist C:Institute of Nano Science and Technology, Habitat Centre, Phase- 10, Sector- 64, Mohali - 160062, Punjab, India (January 2019 to Present till date )
Scientist B:Institute of Nano Science and Technology, Habitat Centre, Phase- 10, Sector- 64, Mohali - 160062, Punjab, India (February 2015 to December 2018 )
Awarded Early Career Research Award by SERB, DST, GOI.
Awarded Bill Melinda Gates-ICID Travel Grant for presenting work at ICID March 2-5, 2016, Hyderabad, India.
Awarded International Travel Award from ICMR for presenting work at International Congress & Exhibition on Nanobiotechnology organized by Centre of Nanotechnology from June 2- 4th 2014 in Munster, Germany.
Awarded Rajiv Gandhi National Fellowship 2011-12 by University Grants Commission, New Delhi, India for pursuing Ph.D.
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