Faculty Directory

Dr. Sharmistha Sinha

(Associate Professor, Scientist-E, Head of the Unit)

In our laboratory, we explore the molecular confinement and self-assembly of biomaterials towards understanding the structure-assembly relationship in bacterial microcompartments. These studies will help the design and bioengineering of novel smart hybrid nano-bioreactors. Further, we are also interested in understanding protein and small-molecule assembly principles in cancer progression and management.   Do visit our Research page for exciting updates!

CONTACT INFORMATION :

Research Interest

  • Protein Self Assembly and Disease Progression.
  • Molecular Confinement and SAR in Prokaryotic Organelles.
  • Novel Functional Organic-Inorganic Hybrid Materials.

Research Highlights

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PhD Students

  • Harmanjit Kaur

    Email: harmanjit.ph14223@inst.ac.in

    Reg. No.: ph14223

    Working Since Jan, 2015
  • Ms. Ankush Garg

    Email: ankush@inst.ac.in

    Reg. No.: PH15206

    Working Since Aug, 2015
  • Ms.Simerpreet Kaur

    Email: simerpreet.ph17224@inst.ac.in

    Reg. No.: PH17224

    Working Since Jan, 2018
  • Ms. Harpreet Kaur

    Email: harpreet.ph19201@inst.ac.in

    Reg. No.: PH19201

    Working Since Aug, 2019
  • Mr. Gaurav Kumar

    Email: gaurav.phd17202@inst.ac.in

    Reg. No.: Ph17202

    Working Since Aug, 2017
  • Ms. Silky

    Email: silky.ph19202@inst.ac.in

    Reg. No.: PH19202

    Working Since Aug, 2019

PhD Students

  • Mr. Naimat Kalim Bari

    Email: barinaimat@gmail.com

    Reg. No.: PH14210


  1. Temporal control in tritylation reactions through light-driven variation in chloride ion binding catalysis–A proof of concept: Surbhi Grewal Saonli Roy Himanshu Kumar Mayank Saraswat Naimat K Bari Sharmistha Sinha Sugumar Venkataramani, (2020) Catalysis Science & Technology, Just Accepted: Just Accepted. DOI: Just Accepted

  2. Probe into a Multi-Protein Prokaryotic Organelle Using Thermal Scanning Assay Reveals Distinct Properties of the Core and the Shell: Dr. Naimat K Bari ,Jagadish P Hazra ,Gaurav Kumar,Simerpreet Kaur,SHARMISTHA SINHA, (2020) BBA - General Subjects, 1864(10): 129680. DOI: 10.1016/j.bbagen.2020.129680

  3. Variable Mutations at the p53-R273 Oncogenic Hotspot Position Leads to Altered Properties: Ankush Garg , Jagadish Prasad Hazra 2, Malay Kumar Sannigrahi 2, Sabyasachi Rakshit 3, Sharmistha Sinha, (2019) Biophysical Journal, 118 (3): 720-728. DOI: 10.1016/j.bpj.2019.12.015

  4. Functional protein shells fabricated from the self-assembling protein sheets of prokaryotic organelles: Naimat K. Bari, Gaurav Kumar , Jagadish P. Hazra, Simerpreet Kaur ,Sharmistha Sinha, (2019) Journal of Materials Chemistry B, 8: 523-533. DOI: https://doi.org/10.1039/C9TB02224D

  5. Cellulose-metallothionein matrix for metal binding: Naimat K.Bari, Shaswat Barua, Ankush Garg, Malay K.Sannigrahi, (2018) Carbohydrate Polymer, 192: 126-134. DOI: 10.1016/j.carbpol.2018.03.043

  6. Nanoparticle Fabrication on Bacterial Microcompartment Surface for the Development of Hybrid Enzyme-Inorganic Catalyst.: Naimat Kalim Bari , Gaurav Kumar, Aashish Bhatt, Jagadish Prasad Hazra, Ankush Garg, Md. Ehesan Ali, (2018) ACS Catal., 8: 7742–7748. DOI: 10.1021/acscatal.8b02322

  7. The Wrappers of the 1,2-Propanediol Utilization Bacterial Microcompartments.: Naimat K Bari, Gaurav Kumar, Sharmistha Sinha, (2018) Adv Exp Med Biol ., 1112: 333-344.. DOI: 10.1007/978-981-13-3065-0_23

  8. Enhanced bacterial cellulose production from Gluconobacter xylinus using super optimal broth: Prathna T. Chandrasekaran, Naimat Kalim Bari, (2017) Cellulose, 24(10): 4367–4381.

  9. Selective molecular transport through the protein shell of a bacterial microcompartment organelle: Chowdhury C, Chun S, Pang A, Sawaya MR, Sinha S, Yeates TO, Bobik TA., (2015) Proc Natl Acad Sci U S A., 112(10): 2990-5. DOI: 10.1073/pnas.1423672112

  10. Alanine scanning mutagenesis identifies an asparagine-arginine-lysine triad essential to assembly of the shell of the Pdu microcompartment: Shouqiang Cheng, Yea Won Sung, Dan E. McNamara, Michael R. Sawaya, Todd O. Yeates, Thomas A. Bobik. J., (2014) J. Mol. Biol., 26(12): 2328-45. DOI: 10.1016/j.jmb.2014.04.012

  11. Diverse bacterial microcompartment organelles: Chowdhury C, Sinha S, Chun S, Yeates TO, Bobik TA., (2014) Microbiol Mol Biol Rev., 78(3): 438-68. DOI: 10.1128/MMBR.00009-14

  12. Interactions between the termini of lumen enzymes and shell proteins mediate enzyme encapsulation into bacterial microcompartments: Sharmistha Sinha, (2012) PNAS, 109(37): 14995-5000. DOI: doi: 10.1073/pnas.1207516109

  13. Comparison of Three Amyloid Assembly Inhibitors: The Sugar Scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01: Sharmistha Sinha 1, Zhenming Du, Panchanan Maiti, Frank-Gerrit Klärner, Thomas Schrader, Chunyu Wang, Gal Bitan, (2012) ACS Chemical Neuroscience, 3(6): 451-8. DOI: DOI: 10.1021/cn200133x

  14. A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity: Sharmistha Sinha,Dahabada H. J. Lopes,Gal Bitan. ACS Chem. Neurosci., (2012) ACS Chem. Neurosci., 3 (6): 473–481. DOI: 10.1021/cn3000247

  15. Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins: Sharmistha Sinha, Dahabada H. J. Lopes, Zhenming Du, Eric S. Pang, Akila Shanmugam, Aleksey Lomakin, Peter Talbiersky, Annette Tennstaedt, Kirsten McDaniel, Reena Bakshi, Pei-Yi Kuo, Michael Ehrmann, George B. Benedek, Joseph A. Loo, Frank-Gerrit Klärner, Thomas Schrader, Chunyu Wang, and Gal Bitan J. Am. Chem. Soc, (2011) J. Am. Chem. Soc., 133 (42): 16958–16969. DOI: 10.1021/ja206279b

  1. Application of Photochemical Cross-linking to the Study of Oligomerization of Amyloidogenic Proteins: Lopes DHJ, C Rosensweig, G Bitan., (2012) Methods Mol Biol., 849: 11-21.

  2. Amyloids and Protein Aggregation—Analytical Methods: Li H, F Rahimi, K Murakami, P Maiti, G Bitan., (2009) Encyclopedia of Analytical Chemistry., .

  1. Molecular Tweezers for the Treatment of Amyloid-Related Diseases: P. Talbiersky, A. Lomakin, F.-G. Klärner, T. Schrader, S. Frautschy,G. Bitan., (2010) .

  2. New compounds for the treatment of diseases related to protein misfolding: T Schrader, K Hochdorffer, J Marz-Berberich, L Nagel-Steger, G Bitan, (2010) .

  3. XVIII International Symposium on Glycoconjugates (GLYCO-18): Florence, Italy, (2005) .

  1. The 56th Biophysical Society Meeting: SanDiego, CA, (2012) .

  2. The 23rd Symposium of the Protein Society, Boston: MA, (2009) .

  3. XVII International Symposium on Glycoconjugates (GLYCO-17): Bangalore, (2002) .

Fundings

  • Understanding the Forces Involved in the Packing of Enzymes Inside the Bacterial Microcompartments for the Development of Novel Encapsulated Bio-Systems 3y, DBT, GoI
    Funding Amount: 58 lakhs
    PI: Dr. Sharmistha Sinha
  • Exploring the shell proteins of BMCPs as potential substrate for fabrication of Organic-Inorganic Hybrid Nanomaterials 3y, DST Nano Mission
    Funding Amount: 47 lakhs
    PI: Dr. Sharmistha Sinha Co-PI: Dr. Ehesan Ali
  • Cellulose-protein binary conjugates for metal detoxification 3y, SERB-Women Excellence Award
    Funding Amount: 18 lakhs
    PI: Dr. Sharmistha Sinha
  • Cell-free bioreactors from the shell proteins of bacterial microcompartments 3y, SERB
    Funding Amount: 47 lakhs
    PI: Dr. Sharmistha Sinha
  • Biological treatment of engineered nanomaterials-contaminated wastewater-feasibility and implication Two Years, INST
    Funding Amount: 10 Lakhs
    Role PI: Dr. Sonalika Vaidya Role Co-PI: Dr. Sharmistha Sinha

  • 2006

    PhD (Biophysics)

    Molecular Biophysics Unit, Indian Institute of Science, Bangalore, INDIA.

  • Postdoctoral Fellow:Dept. of Biochem. Biophys. and Mol. Biol., Iowa State University, Ames,, USA (April 2010 to April 2013 )

  • Postdoctoral Fellow:Dept. of Neurology, University of California, Los Angeles,, USA (March 2008 to March 2010 )

  • Research Associate:Indian Institute of Science, Bangalore,, India (April 2007 to April 2008 )

Awards & Honours


Professional Recognitions