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Dr. Sangita Roy

Assistant Professor (Scientist-D)

Our research focuses on design and development of new biofunctional nanomaterials based on sugar-peptide conjugates using molecular self-assembly approach. These supramolecular nanomaterial scaffolds will be explored towards solving the problems of biology (e.g. drug delivery, cancer therapy, diagonistics) and energy resources.

CONTACT INFORMATION :

Research Interest

  • Our research focuses on design and development of new biofunctional nanomaterials based on sugar-peptide conjugates. Molecular self-assembly approach will be followed for bottom-up nanofabrication of these soft namomaterials to generate a variety of nanostructures. These supramolecular nanomaterial scaffolds will be explored towards solving the problems of biology (e.g. drug delivery, cancer therapy, regenerative medicine) and energy resources.

Research Highlights

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PhD Students

  • Ms. Pooja Sharma

    Email: pooja.ph16220@inst.ac.in

    Reg. No.: PH16220

    Working Since Jul, 2016

  • Ms. Harsimran Kaur

    Email: harsimran.ph15208@inst.ac.in

    Reg. No.: PH15208

    Working Since Jul, 2015

  • Ms. Archita Sharma

    Email: archita.ph19203@inst.ac.in

    Reg. No.: PH19203

    Working Since Aug, 2019

  • Ms. Rashmi Jain

    Email: rashmi.ph14203@inst.ac.in

    Reg. No.: PH14203

    Working Since Jul, 2014

  • Mr. Vijay Kumar Pal

    Email: vijay.ph16235@inst.ac.in

    Reg. No.: PH16235

    Working Since Jan, 2017

  • Mr. Sourav Sen

    Email: sourav.ph18211@inst.ac.in

    Reg. No.: PH18211

    Working Since Aug, 2018

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  1. Controlling Neuronal Cell Growth through Composite Laminin Supramolecular Hydrogels: R. Jain, S. Roy, (2020) ACS Biomater. Sci. Eng., 6(5): 2832–2846. DOI: 10.1021/acsbiomaterials.9b01998

  2. Tuning the gelation behavior of short laminin derived peptides via solvent mediated self-assembly: R. Jain,S Roy, (2020) Mater. Sci. Eng C, 108: 110483.. DOI: 10.1016/j.msec.2019.110483

  3. Tuning supramolecular structure and function of collagen mimetic ionic complementary peptides via electrostatic interactions: VK Pal, R. Jain, S. Roy, (2019) Langmuir, 36 (4): 1003-1013. DOI: 10.1021/acs.langmuir.9b02941

  4. Inducing Differential Self-Assembling Behavior in Ultrashort Peptide Hydrogelators Using Simple Metal Salts: P. Sharma, H. Kaur,S.Roy, (2019) Biomacromolecules, 20 (7): 2610-2624.. DOI: 10.1021/acs.biomac.9b00416

  5. Designing a Tenascin-C-Inspired Short Bioactive Peptide Scaffold to Direct and Control Cellular Behavior: P. Sharma, H. Kaur,S. Roy, (2019) ACS Biomater. Sci. Eng., 5 (12): 6497-6510.. DOI: 10.1021/acsbiomaterials.9b01115

  6. Designing bioactive scaffold from coassembled collagen-laminin short peptide hydrogels for controlling cell behaviour,: R. Jain,S. Roy, (2019) RSC Advances, 9: 38745 – 38759.. DOI: 10.1039/C9RA07454F

  7. Tunable Supramolecular Gels by Varying Thermal History: S. Debnath†, Y.M. Abul-Haija, P. Frederix, S. Ramalhete, A. Hirst, N. Javid, N. Hunt. S. Kelly, J. Angulo, Y. Khimyak,R.V. Ulijn, (2019) Chem. Eur. J., . DOI: 10.1002/chem.201806281

  8. Unravelling the Design Rules in Ultrashort Amyloid-Based Peptide Assemblies toward Shape-Controlled Synthesis of Gold Nanoparticles: R. Jain, G. Khandelwal,S. Roy, (2019) Langmuir, 35: 5878−5889.. DOI: 10.1021/acs.langmuir.8b04020

  9. Pathway-dependent Gold Nanoparticle Formation by Biocatalytic Self-assembly: J.K. Sahoo, N. Javid, K.L. Duncan, L.A. Aitken, R.V. Ulijn, (2017) Nanoscale, 9: 12330.. DOI: 10.1039/C7NR04624C

  10. Tunable Supramolecular Hydrogels for Selection of Lineage-Guiding Metabolites in Stem Cell Cultures: E.V. Alakpa, V. Jayawarna, A. Lampel, K.V. Burgess, C.C. West, S.C.J. Bakker, N. Javid, S. Fleming, D.A. Lamprou, J. Yang, A. Miller, A.J. Urquhart, P.W.J.M. Frederix, N.T. Hunt, B.Péault, R.V. Ulijn and M. J. Dalby, (2016) Chem, 1: 298-319.. DOI: 10.1016/j.chempr.2016.07.001

  11. Biocatalytically Triggered Co-Assembly of Two-Component Core/Shell Nanofibers,: Y. M. Abul-Haija, P. W. J. M. Frederix, N. Javid, V. Jayawarna and R.V. Ulijn, (2014) Small, 10: 973-979.. DOI: 10.1002/smll.201301668

  12. Cooperative Self-Assembly of Peptide Gelators and Proteins: N. Javid, M. Zelzer, Z. Yang, J. Sefcik and R.V. Ulijn, (2013) Biomacromolecules, 14: 4368–4376.. DOI: 10.1021/bm401319c

  13. Peptide Nanofibers with Dynamic Instability through Non-Equilibrium Biocatalytic Assembly: S. Debnath,R.V. Ulijn, (2013) J. Am. Chem. Soc., 135: 16789-16792. DOI: 10.1021/ja4086353

  14. Pickering Stabilized Peptide Gel Particles as Tunable Microenvironments for Biocatalysis: G. Scott, Y. M. Abul-Haija, S. Fleming, S. Bai and R.V. Ulijn, (2013) Langmuir, 29: 14321-14327.. DOI: 10.1021/la403448s

  15. Salt-Induced Control of Supramolecular Order in BiocatalyticHydrogelation: N. Javid, J. Sefcik, P. J. Halling,R. V. Ulijn, (2012) Langmuir, 28: 16664–16670.

  16. Dramatic Specific Ion Effect in Supramolecular Hydrogels: N. Javid, P. W. J. M. Frederix, D. A. Lamprou, A. J. Urquhart, N. T. Hunt, P. J. Halling,R. V. Ulijn, (2012) Chem. Eur. J., 18: 11723-11731. DOI: 10.1002/chem.201201217

  17. Exploiting CH-π Interactions in Supramolecular Hydrogels of Aromatic Carbohydrate Amphiphiles,: L. S. Birchall, V. Jayawarna, M. Hughes, E. Irvine, G. T. Okorogheye, N. Saudi, E. De Santis, T. Tuttle, A. A. Edwards and R. V. Ulijn, (2011) Chem. Sci., 2: 1349-1355. DOI: 10.1039/C0SC00621A

  18. Supramolecular Structures of Enzyme Clusters: N. Javid, K. Vogtt, A. R. Hirst, A. Hoell, I. W. Hamley, R. V. Ulijn and J. Sefcik, (2011) J. Phys. Chem. Lett., 2: 1395-1399.. DOI: 10.1021/jz200446j

  19. Fmoc Hydrogels from Aromatic Carbohydrate Amphiphiles, J. Pharm. Pharmacol: A. A. Edwards, L. S. Birchall, V. Jayawarna, M. Hughes, T. Tuttle, N. Saudi, G. Okorgheye, R. V. Ulijn, (2010) The UK-PharmSci Conference, The Science of Medicine, 62: 1331-1332. DOI: 10.1111/j.2042-7158.2010.01178.x

  20. Exploiting Biocatalysis in the Synthesis of Supramolecular Polymers, Enzymatic Polymerisations,: R.V. Ulijn, (2010) Advances in Polymer Science, 237: 127-143.. DOI: 10.1007/12_2010_75

  21. Biocatalytic Induction of Supramolecular Order, Nature Chemistry: A. R. Hirst†, M. Arora, A. K. Das, N. Hodson, P. Murray, N. Javid, J. Sefcik, J. Boekhoven, J.H. van Esch, S. Santabarbara, N. T. Hunt and R. V. Ulijn, (2010) Nature Chemistry, 2: 1089-1094. DOI: 10.1038/nchem.861

  22. Surfactant-Stabilized Small Hydrogel Particles in Oil: Hosts for Remarkable Activation of Enzymes in Organic Solvents: D. Das, S. Debnath, and P. K. Das, (2010) Chem. Eur. J, 16: 4911-4922.. DOI: 10.1002/chem.200903205

  23. Antimicrobial Activity of Amino Acids and Dipeptide-based Amphiphiles, J. Biotech. 2008, 136, S28–S29 (Biotechnology for the Sustainability of Human Society: N. Kayal, R. N. Mitra, P. K. Das, (2008) International Biotechnology Symposium and Exhibition IBS, 136: .

  24. Antibacterial Hydrogels of Amino Acid-Based Cationic Amphiphiles.: P. K. Das, (2008) Biotech. Bioeng, 100: 756-764.. DOI: 10.1002/bit.21803

  25. Structure and Properties of Low Molecular Weight Amphiphilic Peptide Hydrogelators: R. N. Mitra, D. Das, and P. K. Das, (2007) J. Phys. Chem. B, 111: 14107-14113. DOI: 10.1021/jp076495x

  26. Nonionic Surfactants: A Key to Enhance the Enzyme Activity at Cationic Reverse Micellar Interface.: A. Shome, and P. K. Das., (2007) Langmuir, 23: 4130-4136.. DOI: 10.1021/la062804j

  27. Alkyl Chain Length Dependent Hydrogelation of L-Tryptophan Based Amphiphile.: A. Dasgupta, and P. K. Das., (2007) Langmuir, 23: 11769-11776.. DOI: 10.1021/la701558m

  28. Tailoring of Horseradish Peroxidase Activity in Cationic Water-in-Oil Microemulsions: A. Dasgupta, and P. K. Das, (2006) Langmuir, 22: 4567-4573.. DOI: 10.1021/la0602867

  29. A Control Over Accessibility of Immobilized Enzymes through Porous Coating Layer: K. Mohanta, A. J. Pal, and P. K. Das, (2006) J. Colloid Interface Sci., 304: 329-334. DOI: 10.1016/j.jcis.2006.08.065

  30. Water Gelation of an Amino Acid Based Hydrogelator.: D. Das, A. Dasgupta, R. N. Mitra, S. Debnath, and P. K. Das, (2006) Chem. Eur. J., 12: 5068-5074. DOI: 10.1002/chem.200501638

  31. Asymmetric Resolution in Ester Reduction by NaBH4 at the Interface of Aqueous Aggregates of Amino Acid, Peptide, and Chiral Counter-ion based Cationic Surfactants.: A. Dasgupta, R. N. Mitra, and P. K. Das, (2006) Chem. Asian. J, 1: 780-788.. DOI: 10.1002/asia.200600206

  32. Physicochemical Studies on Cetylammonium Bromide and its Modified (mono-, di- and trihydroxyethylated) Head Group Analogues. Their Micellization Characteristics in Wwater and Thermodynamic an: D. Mitra, I. Chakraborty, S. C. Bhattacharya, S. P. Moulik, D. Das, and P. K. Das, (2006) J. Phys. Chem. B, 110: 11314-11326.. DOI: 10.1021/jp055720c

  33. Amino Acid Based Cationic Surfactants in Aqueous Solutions: Physicochemical Study and Application of Supramolecular Chirality in Ketone Reduction: D. Das, A. Dasgupta, R. N. Mitra, and P. K. Das, (2005) Langmuir, 21: 10398-10404.. DOI: 10.1021/la051548s

  34. Head Group Size or Hydrophilicity of Surfactant: the Major Regulator of Lipase Activity in Cationic w/o Microemulsions.: D. Das, R. N. Mitra, A. Dasgupta and P. K. Das, (2005) Chem. Eur. J., 11: 4881-4889. DOI: 10.1002/chem.200500244

  35. Geometric Constraints at the Surfactant Head Group: Effect on Lipase Activity in Cationic Reverse Micelles.: R. N. Mitra, A. Dasgupta, D. Das, S. Debnath, and P. K. Das, (2005) Langmuir, 21: 12115-12123.. DOI: 10.1021/la052226r

  36. Efficient and Simple NaBH4 Reduction of Esters at Cationic Micellar Surface: D. Das, and P. K. Das, (2004) Org. Lett., 6: 4133-4136.. DOI: 10.1021/ol0481176

  1. Tuning the gelation behavior of short laminin derived peptides via solvent mediated self-assembly: R. Jain,S Roy, (2020) Mater. Sci. Eng C, 108: 110483.. DOI: 10.1016/j.msec.2019.110483

  1. Exploiting Biocatalysis in the Synthesis of Supramolecular Polymers, Enzymatic Polymerisations: R.V. Ulijn, (2010) Advances in Polymer Science, 237: 127-143..

  1. 8th Chandigarh Science Congress (Chascon-2014), Panjab University: Chandigarh Science Congress, (2014) .

  2. International Conference on Interdisciplinary areas with Chemical Sciences (ICIACS 2013), Panjab University: Chemical Sciences, (2013) .

  3. Highly Tunable Gels via Non-equilibrium Biocatalytic Self-assembly, UK-India Symposium on Molecular Materials Chemistry, University of Strathclyde: R. V. Ulijn, (2012) .

  4. Peptide Hydrogels via Non-equilibrium Biocatalytic Self-assembly, RAMS Meeting, University of Strathclyde: R. V. Ulijn, (2012) .

  5. Self-assembled Peptide Nanostructures: A Microscopic Insight, AFM Users Meeting: V. Jayawarna, R. V. Ulijn, (2012) .

  6. Biocatalytic Self-Assembly of Supramolecular Polymers, 10th International Conference in Materials Chemistry: R. V. Ulijn, (2011) .

Fundings

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  • 2009

    PhD

    Indian Association for the Cultivation of Science, Kolkata, India.

  • 2002

    MSc

    Department of Chemistry, University of Calcutta, India.

  • 2000

    BSc

    Department of Chemistry, University of Calcutta, India.

  • Visiting Scientist:Institute of Nano Science and Technology,, Mohali (July 2013 to January 2014 )

  • Post Doctoral Research Fellow:Department of Pure & Applied Chemistry, University of Strathclyde,, Glasgow, UK (April 2009 to April 2013 )

  • Consultant:BioGelx, Glasgow,, UK (April 2011 to April 2013 )

  • PhD Research Fellow:Department of Biological Chemistry, Indian Association for the Cultivation of Science,, Kolkata, India (April 2004 to May 2009 )

  • Project Associate:ChemBiotek Research International Pvt. Ltd.,, Kolkata, India (April 2002 to May 2003 )

Awards & Honours

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Professional Recognitions

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