Associate Professor (Scientist-E)
Our research focuses on the biomolecular engineering for the
development of simple gel-based biomaterials. We aim to combine the two key
processes of Biology, ‘catalysis’ and ‘self-assembly’ to achieve certain
advanced functions within the nanobiomaterials. In particular, we are engaged
in designing and developing the new biofunctional nanomaterials based on sugar-peptide
conjugates using molecular self-assembly approach. These supramolecular
nanomaterial scaffolds are explored towards solving the problems of biology
(e.g. drug delivery, cancer therapy, diagonistics) and energy resources. We are
specifically keen to develop new strategies using these biomaterials and cells
from diverse origin for tissue repair and regeneration. More specifically, we
are interested in: (a) developing molecularly-engineered short peptide
scaffolds based on ECM proteins, such as Laminin and Collagen, Elastin, which
are decorated with various polysaccharides to control and direct the cellular
fate (b) controlling the cell-microenvironment (biophysical, biochemical and
biomechanical cues) interactions through differential self-assembly pathways to
understand cell biology and (c) translate these fundamental understandings
towards clinical applications. Our group is also exploring toward unravelling
the the design rules for the short peptide based self-assembling monomers that
are inspired by biology and can develop unique properties in their
self-assembled state, such as adaptability, molecular recognition and
programmability.
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Email: sweta.ph21250@inst.ac.in
Reg. No.: PH21250
Email: rakesh.ph21231@inst.ac.in
Reg. No.: PH21231
Email: archita.ph19203@inst.ac.in
Reg. No.: PH19203
Email: arushi.ph20223@inst.ac.in
Reg. No.: PH20223
Email: shambhavi.ph20222@inst.ac.in
Reg. No.: PH20222
Email: japleen.ph20221@inst.ac.in
Reg. No.: PH20221
Email: pooja.ph16220@inst.ac.in
Reg. No.: PH16220
Email: vijay.ph16235@inst.ac.in
Reg. No.: PH16235
Email: sourav.ph18211@inst.ac.in
Reg. No.: PH18211
Email: harsimran.ph15208@inst.ac.in
Reg. No.: PH15208
Email: rashmi.jain715@gmail.com
Reg. No.: PH14203
Exploring the TEMPO-Oxidized Nanofibrillar Cellulose and Short Ionic-Complementary Peptide Composite Hydrogel as Biofunctional Cellular Scaffolds: P. Sharma, V. K. Pal, H. Kaur, S. Roy, (2022) Biomacromolecules, ASAP: ASAP. DOI: doi.org/10.1021/acs.biomac.2c00234
Recent developments in biomass derived cellulose aerogel materials for thermal insulation application: a review: S. Sen, A. Singh, C. Bera, S. Roy, K. Kailasam, (2022) Cellulose, -: -. DOI: doi.org/10.1007/s10570-022-04586-7
Cooperative Metal Ion Coordination to the Short Self-Assembling Peptide Promotes Hydrogelation and Cellular Proliferation: V.K. Pal, S. Roy, (2022) Macromol. Biosci., 22: 2100462. DOI: doi.org/10.1002/mabi.202100462
Designing Nanofibrillar Cellulose Peptide conjugated polymeric hydrogel scaffold for controlling cellular behaviour: V.K. Pal, R. Jain, S. Sen, K. Kailasam, S. Roy, (2021) Cellulose, 28: 10335–10357. DOI: doi.org/10.1007/s10570-021-04176-z
Designing aromatic N-cadherin mimetic short-peptide-based bioactive scaffolds for controlling cellular behaviour: H. Kaur, S. Roy, (2021) J. Mater. Chem. B, 9: 5898-5913. DOI: doi.org/10.1039/D1TB00598G
Enzyme-Induced Supramolecular Order in Pyrene Dipeptide Hydrogels for the Development of an Efficient Energy-Transfer Template: H. Kaur,S. Roy, (2021) Biomacromolecules, 22 (6): 2393–2407. DOI: doi.org/10.1021/acs.biomac.1c00187
An overview of latest advances in exploring bioactive peptide hydrogels for neural tissue engineering: P. Sharma, V. K. Pal, S. Roy, (2021) Biomater. Sci., 9: 3911-3938. DOI: doi.org/10.1039/D0BM02049D
Elastin-inspired supramolecular hydrogels: a multifaceted extracellular matrix protein in biomedical engineering: A. Sharma, P. Sharma, S. Roy, (2021) Soft Matter, 17: 3266-3290. DOI: doi.org/10.1039/D0SM02202K
Pathway-Dependent Preferential Selection and Amplification of Variable Self-Assembled Peptide Nanostructures and Their Biological Activities: H. kaur, R. Jain, S. Roy, (2020) ACS Appl. Mater. Interfaces, 12 (47): 52445–52456. DOI: doi.org/10.1021/acsami.0c16725
Accessing Highly Tunable Nanostructured Hydrogels in a Short Ionic Complementary Peptide Sequence via pH Trigger: H. Kaur, P. Sharma, N. Patel, V. K. Pla, S. Roy, (2020) Langmuir, 36 (41): 12107–12120. DOI: doi.org/10.1021/acs.langmuir.0c01472
Triggering Supramolecular Hydrogelation Using a Protein–Peptide Coassembly Approach: R. Jain, V. K. Pal, S. Roy, (2020) Biomacromolecules, 21 (10): 4180–4193. DOI: doi.org/10.1021/acs.biomac.0c00984
Controlling Neuronal Cell Growth through Composite Laminin Supramolecular Hydrogels: R. Jain, S. Roy, (2020) ACS Biomater. Sci. Eng., 6(5): 2832–2846. DOI: 10.1021/acsbiomaterials.9b01998
Tuning the gelation behavior of short laminin derived peptides via solvent mediated self-assembly: R. Jain,S Roy, (2020) Mater. Sci. Eng C, 108: 110483.. DOI: 10.1016/j.msec.2019.110483
Tuning supramolecular structure and function of collagen mimetic ionic complementary peptides via electrostatic interactions: VK Pal, R. Jain, S. Roy, (2019) Langmuir, 36 (4): 1003-1013. DOI: 10.1021/acs.langmuir.9b02941
Inducing Differential Self-Assembling Behavior in Ultrashort Peptide Hydrogelators Using Simple Metal Salts: P. Sharma, H. Kaur,S.Roy, (2019) Biomacromolecules, 20 (7): 2610-2624.. DOI: 10.1021/acs.biomac.9b00416
Designing a Tenascin-C-Inspired Short Bioactive Peptide Scaffold to Direct and Control Cellular Behavior: P. Sharma, H. Kaur,S. Roy, (2019) ACS Biomater. Sci. Eng., 5 (12): 6497-6510.. DOI: 10.1021/acsbiomaterials.9b01115
Designing bioactive scaffold from coassembled collagen-laminin short peptide hydrogels for controlling cell behaviour,: R. Jain,S. Roy, (2019) RSC Advances, 9: 38745 – 38759.. DOI: 10.1039/C9RA07454F
Tunable Supramolecular Gels by Varying Thermal History: S. Debnath†, Y.M. Abul-Haija, P. Frederix, S. Ramalhete, A. Hirst, N. Javid, N. Hunt. S. Kelly, J. Angulo, Y. Khimyak,R.V. Ulijn, (2019) Chem. Eur. J., . DOI: 10.1002/chem.201806281
Unravelling the Design Rules in Ultrashort Amyloid-Based Peptide Assemblies toward Shape-Controlled Synthesis of Gold Nanoparticles: R. Jain, G. Khandelwal,S. Roy, (2019) Langmuir, 35: 5878−5889.. DOI: 10.1021/acs.langmuir.8b04020
Pathway-dependent Gold Nanoparticle Formation by Biocatalytic Self-assembly: J.K. Sahoo, N. Javid, K.L. Duncan, L.A. Aitken, R.V. Ulijn, (2017) Nanoscale, 9: 12330.. DOI: 10.1039/C7NR04624C
Tunable Supramolecular Hydrogels for Selection of Lineage-Guiding Metabolites in Stem Cell Cultures: E.V. Alakpa, V. Jayawarna, A. Lampel, K.V. Burgess, C.C. West, S.C.J. Bakker, N. Javid, S. Fleming, D.A. Lamprou, J. Yang, A. Miller, A.J. Urquhart, P.W.J.M. Frederix, N.T. Hunt, B.Péault, R.V. Ulijn and M. J. Dalby, (2016) Chem, 1: 298-319.. DOI: 10.1016/j.chempr.2016.07.001
Biocatalytically Triggered Co-Assembly of Two-Component Core/Shell Nanofibers,: Y. M. Abul-Haija, P. W. J. M. Frederix, N. Javid, V. Jayawarna and R.V. Ulijn, (2014) Small, 10: 973-979.. DOI: 10.1002/smll.201301668
Peptide Nanofibers with Dynamic Instability through Non-Equilibrium Biocatalytic Assembly: S. Debnath,R.V. Ulijn, (2013) J. Am. Chem. Soc., 135: 16789-16792. DOI: 10.1021/ja4086353
Cooperative Self-Assembly of Peptide Gelators and Proteins: N. Javid, M. Zelzer, Z. Yang, J. Sefcik and R.V. Ulijn, (2013) Biomacromolecules, 14: 4368–4376.. DOI: 10.1021/bm401319c
Pickering Stabilized Peptide Gel Particles as Tunable Microenvironments for Biocatalysis: G. Scott, Y. M. Abul-Haija, S. Fleming, S. Bai and R.V. Ulijn, (2013) Langmuir, 29: 14321-14327.. DOI: 10.1021/la403448s
Salt-Induced Control of Supramolecular Order in BiocatalyticHydrogelation: N. Javid, J. Sefcik, P. J. Halling,R. V. Ulijn, (2012) Langmuir, 28: 16664–16670.
Dramatic Specific Ion Effect in Supramolecular Hydrogels: N. Javid, P. W. J. M. Frederix, D. A. Lamprou, A. J. Urquhart, N. T. Hunt, P. J. Halling,R. V. Ulijn, (2012) Chem. Eur. J., 18: 11723-11731. DOI: 10.1002/chem.201201217
Exploiting CH-π Interactions in Supramolecular Hydrogels of Aromatic Carbohydrate Amphiphiles,: L. S. Birchall, V. Jayawarna, M. Hughes, E. Irvine, G. T. Okorogheye, N. Saudi, E. De Santis, T. Tuttle, A. A. Edwards and R. V. Ulijn, (2011) Chem. Sci., 2: 1349-1355. DOI: 10.1039/C0SC00621A
Supramolecular Structures of Enzyme Clusters: N. Javid, K. Vogtt, A. R. Hirst, A. Hoell, I. W. Hamley, R. V. Ulijn and J. Sefcik, (2011) J. Phys. Chem. Lett., 2: 1395-1399.. DOI: 10.1021/jz200446j
Fmoc Hydrogels from Aromatic Carbohydrate Amphiphiles, J. Pharm. Pharmacol: A. A. Edwards, L. S. Birchall, V. Jayawarna, M. Hughes, T. Tuttle, N. Saudi, G. Okorgheye, R. V. Ulijn, (2010) The UK-PharmSci Conference, The Science of Medicine, 62: 1331-1332. DOI: 10.1111/j.2042-7158.2010.01178.x
Surfactant-Stabilized Small Hydrogel Particles in Oil: Hosts for Remarkable Activation of Enzymes in Organic Solvents: D. Das, S. Debnath, and P. K. Das, (2010) Chem. Eur. J, 16: 4911-4922.. DOI: 10.1002/chem.200903205
Biocatalytic Induction of Supramolecular Order, Nature Chemistry: A. R. Hirst†, M. Arora, A. K. Das, N. Hodson, P. Murray, N. Javid, J. Sefcik, J. Boekhoven, J.H. van Esch, S. Santabarbara, N. T. Hunt and R. V. Ulijn, (2010) Nature Chemistry, 2: 1089-1094. DOI: 10.1038/nchem.861
Exploiting Biocatalysis in the Synthesis of Supramolecular Polymers, Enzymatic Polymerisations,: R.V. Ulijn, (2010) Advances in Polymer Science, 237: 127-143.. DOI: 10.1007/12_2010_75
Antimicrobial Activity of Amino Acids and Dipeptide-based Amphiphiles, J. Biotech. 2008, 136, S28–S29 (Biotechnology for the Sustainability of Human Society: N. Kayal, R. N. Mitra, P. K. Das, (2008) International Biotechnology Symposium and Exhibition IBS, 136: .
Antibacterial Hydrogels of Amino Acid-Based Cationic Amphiphiles.: P. K. Das, (2008) Biotech. Bioeng, 100: 756-764.. DOI: 10.1002/bit.21803
Alkyl Chain Length Dependent Hydrogelation of L-Tryptophan Based Amphiphile.: A. Dasgupta, and P. K. Das., (2007) Langmuir, 23: 11769-11776.. DOI: 10.1021/la701558m
Structure and Properties of Low Molecular Weight Amphiphilic Peptide Hydrogelators: R. N. Mitra, D. Das, and P. K. Das, (2007) J. Phys. Chem. B, 111: 14107-14113. DOI: 10.1021/jp076495x
Nonionic Surfactants: A Key to Enhance the Enzyme Activity at Cationic Reverse Micellar Interface.: A. Shome, and P. K. Das., (2007) Langmuir, 23: 4130-4136.. DOI: 10.1021/la062804j
Tailoring of Horseradish Peroxidase Activity in Cationic Water-in-Oil Microemulsions: A. Dasgupta, and P. K. Das, (2006) Langmuir, 22: 4567-4573.. DOI: 10.1021/la0602867
A Control Over Accessibility of Immobilized Enzymes through Porous Coating Layer: K. Mohanta, A. J. Pal, and P. K. Das, (2006) J. Colloid Interface Sci., 304: 329-334. DOI: 10.1016/j.jcis.2006.08.065
Water Gelation of an Amino Acid Based Hydrogelator.: D. Das, A. Dasgupta, R. N. Mitra, S. Debnath, and P. K. Das, (2006) Chem. Eur. J., 12: 5068-5074. DOI: 10.1002/chem.200501638
Asymmetric Resolution in Ester Reduction by NaBH4 at the Interface of Aqueous Aggregates of Amino Acid, Peptide, and Chiral Counter-ion based Cationic Surfactants.: A. Dasgupta, R. N. Mitra, and P. K. Das, (2006) Chem. Asian. J, 1: 780-788.. DOI: 10.1002/asia.200600206
Physicochemical Studies on Cetylammonium Bromide and its Modified (mono-, di- and trihydroxyethylated) Head Group Analogues. Their Micellization Characteristics in Wwater and Thermodynamic an: D. Mitra, I. Chakraborty, S. C. Bhattacharya, S. P. Moulik, D. Das, and P. K. Das, (2006) J. Phys. Chem. B, 110: 11314-11326.. DOI: 10.1021/jp055720c
Amino Acid Based Cationic Surfactants in Aqueous Solutions: Physicochemical Study and Application of Supramolecular Chirality in Ketone Reduction: D. Das, A. Dasgupta, R. N. Mitra, and P. K. Das, (2005) Langmuir, 21: 10398-10404.. DOI: 10.1021/la051548s
Head Group Size or Hydrophilicity of Surfactant: the Major Regulator of Lipase Activity in Cationic w/o Microemulsions.: D. Das, R. N. Mitra, A. Dasgupta and P. K. Das, (2005) Chem. Eur. J., 11: 4881-4889. DOI: 10.1002/chem.200500244
Geometric Constraints at the Surfactant Head Group: Effect on Lipase Activity in Cationic Reverse Micelles.: R. N. Mitra, A. Dasgupta, D. Das, S. Debnath, and P. K. Das, (2005) Langmuir, 21: 12115-12123.. DOI: 10.1021/la052226r
Efficient and Simple NaBH4 Reduction of Esters at Cationic Micellar Surface: D. Das, and P. K. Das, (2004) Org. Lett., 6: 4133-4136.. DOI: 10.1021/ol0481176
Tuning the gelation behavior of short laminin derived peptides via solvent mediated self-assembly: R. Jain,S Roy, (2020) Mater. Sci. Eng C, 108: 110483.. DOI: 10.1016/j.msec.2019.110483
Exploiting Biocatalysis in the Synthesis of Supramolecular Polymers, Enzymatic Polymerisations: R.V. Ulijn, (2010) Advances in Polymer Science, 237: 127-143..
8th Chandigarh Science Congress (Chascon-2014), Panjab University: Chandigarh Science Congress, (2014) .
International Conference on Interdisciplinary areas with Chemical Sciences (ICIACS 2013), Panjab University: Chemical Sciences, (2013) .
Highly Tunable Gels via Non-equilibrium Biocatalytic Self-assembly, UK-India Symposium on Molecular Materials Chemistry, University of Strathclyde: R. V. Ulijn, (2012) .
Peptide Hydrogels via Non-equilibrium Biocatalytic Self-assembly, RAMS Meeting, University of Strathclyde: R. V. Ulijn, (2012) .
Self-assembled Peptide Nanostructures: A Microscopic Insight, AFM Users Meeting: V. Jayawarna, R. V. Ulijn, (2012) .
Biocatalytic Self-Assembly of Supramolecular Polymers, 10th International Conference in Materials Chemistry: R. V. Ulijn, (2011) .
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Indian Association for the Cultivation of Science, Kolkata, India.
Department of Chemistry, University of Calcutta, India.
Department of Chemistry, University of Calcutta, India.
Scientist E:Institute of Nano Science and Technology, Mohali (January 2022 to Present till date )
Scientist D (Assistant Professor):Institute of Nano Science and Technology, Mohali (January 2019 to December 2021 )
Scientist C:Institute of Nano Science and Technology, Mohali (February 2014 to December 2018 )
Visiting Scientist:Institute of Nano Science and Technology,, Mohali (July 2013 to January 2014 )
Post Doctoral Research Fellow:Department of Pure & Applied Chemistry, University of Strathclyde,, Glasgow, UK (April 2009 to April 2013 )
Consultant:BioGelx, Glasgow,, UK (February 2013 to June 2013 )
PhD Research Fellow:Department of Biological Chemistry, Indian Association for the Cultivation of Science,, Kolkata, India (April 2004 to May 2009 )
Project Associate:ChemBiotek Research International Pvt. Ltd.,, Kolkata, India (April 2002 to May 2003 )
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