Dr. Sangita Roy :(Head of Unit)
Associate Professor (Scientist-E), Head of the Unit
Our research focuses on the biomolecular engineering for the development of simple gel-based biomaterials. We aim to combine the two key processes of Biology, ‘catalysis’ and ‘self-assembly’ to achieve certain advanced functions within the nanobiomaterials. In particular, we are engaged in designing and developing the new biofunctional nanomaterials based on sugar-peptide conjugates using molecular self-assembly approach. These supramolecular nanomaterial scaffolds are explored towards solving the problems of biology (e.g. drug delivery, cancer therapy, diagonistics) and energy resources. We are specifically keen to develop new strategies using these biomaterials and cells from diverse origin for tissue repair and regeneration. More specifically, we are interested in: (a) developing molecularly-engineered short peptide scaffolds based on ECM proteins, such as Laminin and Collagen, Elastin, which are decorated with various polysaccharides to control and direct the cellular fate (b) controlling the cell-microenvironment (biophysical, biochemical and biomechanical cues) interactions through differential self-assembly pathways to understand cell biology and (c) translate these fundamental understandings towards clinical applications. Our group is also exploring toward unravelling the the design rules for the short peptide based self-assembling monomers that are inspired by biology and can develop unique properties in their self-assembled state, such as adaptability, molecular recognition and programmability.
Contact Information :
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E-mail:
sangita@inst.ac.in -
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