Colorectal cancer is one of the greatest causes of cancer related mortalities on the global scale. In the context of cancer chemotherapy, synthetic lethality is a recent paradigm where interaction of two genes is explored, such that simultaneous inhibition or silencing of both the genes becomes lethal for the cancer cells while bearing least impact on the healthy cells. Our research deals with the formulation and characterization of novel nanoparticles for drug delivery purposes for synthetic lethal therapy mediated targeting of colorectal cancer. Most of the anti-cancer compounds have various limitations like solubility issues, poor bioavailability and off target effects which restrict their employability in the clinical platforms. To surpass these limitations, we develop customized nanoparticles for enhanced therapeutic efficacy and selective or targeted therapy of cancer.
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Aminocellulose-Grafted-Polycaprolactone Coated Gelatin Nanoparticles Alleviate Inflammation in Rheumatoid Arthritis: A Combinational Therapeutic Approach: Md. Meraj Ansari, Anas Ahmad, Ajay Kumar, Pravej Alam, Tajdar Husain Khan, Govindasamy Jayamurugan, Syed Shadab Raza, Rehan Khan*, (2020) Carbohydrate Polymers, NA: NA.
Enema Based Therapy Using Liposomal Formulation of Low Molecular Weight Heparin for Treatment of Active Ulcerative Colitis: New Adjunct Therapeutic Opportunity : Anas Ahmad# , Kalpesh Vaghasiya#, Ajay Kumar , Pravej Alam, Syed Shadab Raza, Rahul Kumar Verma*, Rehan Khan*, (2020) Materials Science and Engineering: C, NA: NA.
Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms: Arafah, A.; Rehman, M.U.; Mir, T.M.; Wali, A.F.; Ali, R.; Qamar, W.; Khan, R.; Ahmad, A.; Aga, S.S.; Alqahtani, S.; Almatroudi, N.M., (2020) Plants, 9: 1784. DOI: 10.3390/plants9121784
Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases: Khan, A.Q.; Akhtar, S.; Prabhu, K.S.; Zarif, L.; Khan, R.; Alam, M.; Buddenkotte, J.; Ahmad, A.; Steinhoff, M.; Uddin, S., (2020) International Journal of Molecular Sciences, 21: 9264. DOI: 10.3390/ijms21239264
Sivelestat-loaded nanostructured lipid carriers modulate oxidative and inflammatory stress in human dental pulp and mesenchymal stem cells subjected to oxygen-glucose deprivation: Prakash R,Mishra RK ,Ahmad A,Khan MA,Rehan Khan,Syed Shadab Raza, (2020) Materials Science and Engineering: C, NA: 111700. DOI: 10.1016/j.msec.2020.111700
Comparative Acute Intravenous Toxicity Study of Triple Polymer Layered Magnetic Nanoparticles with Bare Magnetic Nanoparticles in Swiss Albino Mice: Anas Ahmad, Md. Meraj Ansari, Ajay Kumar, Akshay Vyawahare, Rakesh Kumar Mishra, Govindasamy Jayamurugan, Syed Shadab Raza, Rehan Khan*, (2020) Nanotoxicology, 14: 1362-1380. DOI: 10.1080/17435390.2020.1829144
Enteric-Coated Gelatin Nanoparticles Mediated Oral Delivery of 5-Aminosalicylic Acid Alleviates Severity of DSS-Induced Ulcerative Colitis: Anas Ahmad, Md. Meraj Ansari, Rakesh Kumar Mishra, Ajay Kumar, Akshay Vyawahare, Rahul Kumar Verma, Syed Shadab Raza, Rehan Khan*, (2020) Materials Science and Engineering: C, 119: 111582. DOI: 10.1016/j.msec.2020.111582
Autophagy inducing inhalable Co-crystal formulation of Niclosamide-Nicotinamide for lung cancer therapy: Ray E, Vaghasiya K, Sharma A, Shukla R, Khan R, Kumar A, Verma RK*, (2020) AAPS PharmSciTech, 21: 1-14. DOI: 10.1208/s12249-020-01803-z
Understanding the Monoclonal Antibody Involvement in Targeting the Activation of Tumor Suppressor Genes: Rakesh Kumar Mishra, Anas Ahmad, Akshay Vyawahare, Ajay Kumar, Rehan Khan*, (2020) Current Topics in Medicinal Chemistry, 20: 1810-1823. DOI: 10.2174/1568026620666200616133814
Membrane Trafficking and Subcellular Drug Targeting Pathways.: A Kumar, A Ahmad, A Vyawahare, R Khan*., (2020) Frontiers in Pharmacology, . DOI: 10.3389/fphar.2020.00629
Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis.: Mishra RK, Ahmad A, Kumar A, Vyawahare A, Raza SS, Rehan Khan*, (2020) Materials Science and Engineering: C, 116: 111103. DOI: 10.1016/j.msec.2020.111103
Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review: Muneeb U Rehman, Adil Farooq, Rayeesa Ali, Sana Bashir, Nazirah Bashir, Samia Majeed, Syed Taifa, Sheikh Bilal Ahmad, Azher Arafah, Aga Syed Sameer*, Rehan Khan, Wajhul Qamar, Saiema Rasool, Anas Ahmad., (2020) Current Drug Metabolism, 21: 436-465. DOI: 10.2174/1389200221666200620204914
Hyperbranched polymer-functionalized magnetic nanoparticles mediated hyperthermia and niclosamide bimodal therapy of Colorectal Cancer Cells.: A Ahmad, A Gupta, MM Ansari, A Vyawahare, G Jayamurugan*, R. Khan*, (2019) ACS Biomater. Sci. Eng., 6: 1102-1111. DOI: 10.1021/acsbiomaterials.9b01947
Neuroprotective Strategies for Neurological Disorders by Natural Products: An update: Muneeb U Rehman,F Adil Wali,Anas Ahmad,Sheeba Shakeel,Saiema Rasool,Rayeesa Ali,Shazada Mudasir Rashid,Hasan Madkhali Ganaie,Majid Ahmad,Rehan Khan, (2019) Current Neuropharmacology, 17: 247-267.
Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects: Anas Ahmad,Rakesh Kumar Mishra,Akshay Vyawahare,Ajay Kumar,Muneeb U. Rehman,Wajhul Qamar,Abdul Quaiyoom Khan,Rehan Khan, (2019) Saudi Pharmaceutical Journal, 27: 1113-1126.
Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting: Anas Ahmad,Farheen Khan,Rakesh Kumar Mishra,Rehan Khan, (2019) J. Med. Chem., 62: 10475-10496.
Zinc Gluconate-Loaded Chitosan Nanoparticles Reduce Severity of Collagen-Induced Arthritis in Wistar Rats: Md. Meraj Ansari ,Anas Ahmad,Rakesh Kumar Mishra,Syed Shadab Raza,Rehan Khan, (2019) ACS Biomater. Sci. Eng., .
Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells: A. Gupta, A. AHMAD, H. Singh, S. Kaur, Neethu K M, M. M. Ansari, G. Jayamurugan*, R. Khan*, (2018) Biomacromolecules, 19: 803-815. DOI: 10.1021/acs.biomac.7b01607
Gelatin-Coated Polycaprolactone Nanoparticle-Mediated Naringenin Delivery Rescue Human Mesenchymal Stem Cells from Oxygen Glucose Deprivation-Induced Inflammatory Stress: Anas Ahmad,Eram Fauzia, Manish Kumar,Rakesh Kumar Mishra,Ajay Kumar,Mohsin Ali Khan,Syed Sadab Raza,Rehan Khan, (2018) ACS Biomater. Sci. Eng., 2: 683-695.
Aptamer based nanobiosensors: Promising healthcare devices: Aamir Hanif ,Rabia Farooq,Muneeb U. Rehman,Rehan Khan,Sabhiya majid,Majid Ahmed Ganaie, (2018) Saudi Pharmaceutical Journal, 27: 312–319.
Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers: Rehman MU, Khan AQ, Tahir M, Sultana S., (2018) Environmental Toxicology, .
Synthetic lethality: From Research to Personalized Cancer Nanomedicine.: Gupta A, Ahmad A, Dar AI, (2018) .
Trichloroethylene mediated cytotoxicity in Human Epidermal Keratinocytes is mediated by the rapid accumulation of intracellular calcium: Interception by Naringenin.: Ali F, Khan AQ,Sultana S, (2016) Human and Experimental Toxicology., 35(2): 147-61. DOI: 10.1177/0960327115578865
18-β Glycyrrhetinic acid alleviates 2-Acetylaminofluorene induced hepatotoxicity in wistar rats: Hasan SK, Ali N, Khan AQ, Rehman MU, Tahir M, Lateef A, Nafees S, Mehdi SJ, Rashid S, Shahid A, Sultana S., (2015) Human and Experimental Toxicology, 34(6): 628-41. DOI: 10.1177/0960327114554045
Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice.: Majed F, Rashid S, Khan AQ, Nafees S, Ali N, Ali R,Hasan SK, Mehdi SJ, Sultana S., (2015) Molecular and Cellular Biochemistry, 399(1-2): 217-28. DOI: 10.1007/s11010-014-2248-3
D-limonene suppresses Doxorubicin induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats: Rehman MU, Tahir M, Khan AQ, Oday-O-Hamiza, Lateef A, Hassan SK, Rashid S, Ali N, Zeeshan M, Sultana S, (2014) Experimental Biology and Medicine (Maywood), 239(4): 465-76. DOI: 10.1177/1535370213520112
Chemopreventive effects of Aloin against DMH-induced preneoplastic lesions in the colonof Wistar rats: Hamiza OO, Rehman MU, Tahir M, Khan AQ, Lateef A, Sultana S., (2014) Human and Experimental Toxicology, 33(2): 148-63. DOI: 10.1177/0960327113493307
Alleviation of hepatic injury by chrysin in cisplatin administered rats: Probable role of inflammatory markers: Rehman MU, Tahir M, Quaiyoom A, Lateef A, Oday-O-Hamiza, Hassan SK, Ali N, Qamar W, Sultana S., (2014) Pharmacol Reports, 66(6): 1050-9. DOI: 10.1016/j.pharep.2014.06.004
Methanolic extract of Terminalia chebula protects against DMH-induced colon damage in Wistar Rats by restoring antioxidant enzyme activities and suppressing inflammation: Hamiza OO,Rehman MU, Tahir M, Lateef A, Khan AQ, Qamar W, Sultana S., (2014) International Journal of Drug Development & Research, 6: 0975-9344..
Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: Possible role of oxidative stress and inflammati: Khan AQ, Tahir M, Lateef A, Rehman MU, Ali F, Hamiza OO, Hasan SK, Sultana S., (2014) Nutrition and Cancer, 66(2): 249-58. DOI: 10.1080/01635581.2014.863365
Assessment of augmented immune surveillance and tumor cell death by cytoplasmic stabilization of p53 as a chemopreventive strategy of three promising medicinal herbs in murine two stage skin: Ali F, Khan AQ, Lateef A, Tahir M, Sultana S., (2013) Integrative Cancer Therapies, 13(4): 351-367. DOI: 10.1177/1534735413513831
Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation.: Tahir M, Rehman MU, Lateef A, Khan AQ, Ali F, Oday-O-Hamiza, Sultana S., (2013) Alcohol, 47(2): 131-9. DOI: 10.1016/j.alcohol.2012.12.010
Diosmin protects against TCE (trichloroethylene) induced renal injury in Wistar rats: Plausible role of p53, Bax and caspases.: Rehman MU, Tahir M, Khan AQ, Lateef A, Oday-O-Hamiza, Ali F, Sultana S., (2013) British Journal of Nutrition, 1-12. DOI: 10.1017/S0007114512005752
Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-κB.: Khan AQ, Qamar W, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Hasan SK, Sultana S., (2013) Experimental and Molecular Pathology, 94(3): 419-429. DOI: 10.1016/j.yexmp.2013.01.006
Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB.: Rehman MU, Tahir M, Khan AQ, Lateef A, Oday-O-Hamiza, Qamar W, Ali F, Sultana S, (2013) Toxicology Letters, 216(2-3): 146-58. DOI: 10.1016/j.toxlet.2012.11.013
Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile and oxidative stress: amelioration by daidzein.: Lateef A, Khan AQ, Tahir M, Rehman MU, Ali F,Hamiza OO, Sultana S., (2013) Molecular and Cellular Biochemistry, 374(1-2): 49-59. DOI: 10.1007/s11010-012-1504-7
Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model.: Tahir M, Rehman MU, Lateef A, Khan AQ, Qamar W, Hamiza OO, Ali F, Hasan SK, Sultana S., (2013) Toxicology Letters, 220(3): 205-18. DOI: 10.1016/j.toxlet.2013.04.004
Glycyrrhizic acid suppresses the development of precancerous lesions via regulating thehyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats.: Khan AQ, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Sultana S., (2013) PLoS One, 8(2): . DOI: 10.1371/journal.pone.0056020
Farnesol protects against intratracheally instilled cigarette smoke extract-induced histological alterations and oxidative stress in prostate of Wistar rats: Lateef A, Rehman MU, Tahir M, Khan AQ, Qamar W, Sultana S., (2013) Toxicology International,, 20(1): 35-42.
Soy isoflavones (daidzein&genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-κB in Swiss albino mice.: Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S., (2012) Toxicology, 302(2-3): 266-74. DOI: 10.1016/j.tox.2012.08.008
Chrysin abrogates cisplatin-induced oxidative stress, p53 expression, goblet cell disintegration and apoptotic responses in the jejunum of Wistar rats.: Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Farrah Ali, Muneeb U. Rehman, Mir Tahir, Swati Sharma and Sarwat Sultana., (2012) British Journal of Nutrition, 108(9): 1574-85.. DOI: 10.1017/S0007114511007239
Nephroprotective efficacy of chrysin against cisplatin induced toxicity via attenuation of oxidative stress.: Sultana S, Verma K, (2012) Journal of Pharmacy and Pharmacology, 64(6): 872-81. DOI: 10.1111/j.2042-7158.2012.01470.x
Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid.: Rehman MU, Tahir M, Ali F, Qamar W, Lateef A, Quaiyoom A, Oday-O-Hamiza, Sultana S., (2012) Molecular and Cellular Biochemistry, 365(1-2): 119-27. DOI: 10.1007/s11010-012-1250-x
Benzo(a)pyrene-Induced Pulmonary Inflammation, Edema, Surfactant Dysfunction, and Injuries in rats: Alleviation by Farnesol.: Qamar W, Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S., (2012) Experimental Lung Research., 38(1): 19-27. DOI: 10.3109/01902148.2011.632064
Caffeic acid attenuates 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-κB and COX-2 expression in mouse skin: Abrogation of oxidative stress, inflammatory responses and proinflammator: Khan AQ, Qamar W, Lateef A, Ali F, Tahir M, Muneeb-U-Rehman, Sultana S., (2012) Food and Chemical Toxicology., 50(2): 175-83.. DOI: 10.1016/j.fct.2011.10.043
Chrysin protects against cisplatin-induced colon toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53.: Khan AQ, Qamar W, Lateef A, Tahir M, Rehman MU Ali F, Sultana S., (2012) Toxicology and Applied Pharmacology, 258(3): 315-29. DOI: 10.1016/j.taap.2011.11.013
Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase.: Qamar W, Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S., (2012) Toxicology, 291(1-3): 25-31. DOI: 10.1016/j.tox.2011.10.012
Methanolic extract of Bacop amonnieri protects against KBrO3-induced renal damage in Wistar rats by restoring antioxidant enzyme activities and suppressing inflammation and apoptosis.: Rehman MU, Tahir M, Khan AQ,Lateef A, Hamiza OO, Kazim S, Ali F, Sultana S., (2012) Journal of Pharmacy Research, 5(11): 5231-5238. DOI: 10.1007/s11010-012-1504-7
Chemopreventive effect of Quercus infectoria against chemically induced renal toxicity and carcinogenesis.: Rehman MU, Tahir M, Ali F, Qamar W, Khan AQ, Lateef A, Hamiza OO, Sultana S., (2012) International Journal of Drug Development & Research, 4 (2): 336-351..
Amelioration of 1,2 Dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats.: Hamiza OO, Rehman MU, Tahir M, Khan AQ, Lateef A, Ali F, Sultana S., (2012) Asian Pac J Cancer Prev., 13(9): 4393-402.. DOI: 10.7314/apjcp.2012.13.9.4393
Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats.: Sultana S., (2011) Chemico-Biological Interactions, 192(3): 193-200.. DOI: 10.1016/j.cbi.2011.03.009
Nano-sized delivery systems for plant-derived therapeutic compounds and their synthetic derivative for cancer therapy: Rehman MU. Amin H, Khan A, Makeen H, Rashid H, Amin Insha, Hussain M, Rehan Khan, Azher Arafah, (2020) Phytomedicine: A Treasure of Pharmacologically Active Products from Plants, .
Naringenin (4, 5, 7-trihydroxyflavanone) as Potent Neuro-protective Agent: From Chemistry to Medicine.: Amin I, Majid S, Farooq A, Isaq S, Wani HA, Farida Noor, Rehan Khan, Shakeel S, Bhat SA, Ahmad A, Madkhali H, Ahmad M, Rehman MU, (2020) Studies in Natural Products Chemistry, 65: NA. DOI: https://doi.org/10.1016/B978-0-12-817905-5.00008-1
A Mechanistic Perspective on Chemopreventive and Therapeutic potential of Phytochemicals in Honey.: A Ali, J Yangchan, A Ahmad, A Kumar, RK Mishra, A Vyawahare, A Rukhsana, GM Ashraf, S Shakil, Rehan Khan*, (2020) Therapeutic Applications of Honey and its Phytochemical, Accepted: NA. DOI: NA
Effect of Pesticides on Fish Fauna: Threats, Challenges, and Possible Remedies: Shafat Ali,Adil Farooq Wali,Ali Mohd Yatoo,Sabhiya Majid,Saiema Rasool,Rehan Khan,Md Niamat Ali,Javaid Ahmad Wani,Sanah Farooq,Shabhat Rasool,Hilal Ahmad Wani,Muneeb U. Rehman, (2020) Bioremediation and Biotechnology, 27-54.
Role of 3D tissue engineering models for human cancer and drug development: Khan AQ,Rashid K,Raza SS,Rehan Khan,Mraiche F,Shahab Uddin, (2019) Animal Models in Cancer Drug Discovery, 309-322.
Chemical Composition and Biological Uses of Artemisia absinthium (Wormwood): Rahil Razzak Bhat,Muneeb U. Rehman,Ambreen Shabir,Manzoor U. Rahman Mir,Anas Ahmad,Rehan Khan,Mubashir Husaain Masoodi,Hassan Madkhali,Majid Ahmad Ganaie, (2019) Springer, 3: 37-63.
An overview of the pharmacological properties and potential applications of lavander and cumin.: Rehman MU,Ahmad SA ,Shah A,Kashani B,Ahmad A,Mishra R,Rehan Khan,Rashid SM,Ali R,Rasool S, (2019) Apple Academic Press, .
Applying synthetic lethality to nanomedicine: LCS-1 loaded magnetite and polymeric nanoparticles for the treatment of BLM and CHEK2-deficient colorectal cancer cells: In CANCER MEDICINE 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY A. Gupta, Ahmad A, (2018) 7: 27-28.
Department of Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India.
Department of Toxicology, Department of Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India.
Department of Botany, Aligarh Muslim University, Aligarh, India.
Scientist-C:Institute of Nano Science and Technology, Phase-10, Mohali (January 2019 to Present till date )
Scientist-B:Institute of Nano Science and Technology, Phase-10, Mohali (February 2015 to December 2018 )
Post-doctoral Fellow:Manitoba Institute of Cell Biology, Cancercare Manitoba, University of Manitoba, Winnipeg,, MB, CANADA. (October 2013 to June 2014 )
Senior Research Fellowship (SRF):Indian Council of Medical Research (ICMR),, New Delhi, India. (June 2011 to October 2013 )
Research Fellowship for Science and Meritorious Student (RFSMS):niversity Grants Commission (UGC),, New Delhi, India. (April 2009 to April 2011 )
Travel Grant awarded by Department of Science and Technology, Ministry of Higher Education, New Delhi, India, for attending international conference “The Tumor Microenvironment” held in Dublin, Ireland in September 2012.
Award from Jamia Hamdard (Hamdard University) for publishing research work in high impact (more than 3.0) journals “PLoS One”, “British Journal of Nutrition” and “Toxicology and Applied Pharmacology”.
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