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Dr. Deepika Sharma

Scientist-D

I am currently working as a Scientist D at the Institute of Nano Science and Technology (INST), Mohali, under the Department of Science and Technology, Government of India. My laboratory’s research interests lie at the intersection of engineering, medicine, and biology, with the aim of developing innovative platforms for understanding, diagnosing, and treating human diseases. In particular, our work focuses on advancing diagnostics and therapies for cancer. We specialize in the design and development of targeted nanoparticles capable of performing complex functions such as multimodal, non-invasive tumor imaging, controlled therapeutic payload release, hyperthermia, and multifunctional cancer therapies. I am also an active member of the Indian Association for Cancer Research (IACR), the Indian Association for Hyperthermic Oncology and Medicine (IAHOM), and the Biotech Research Society of India (BRSI).

Contact Information :

  • Dr. Sharma’s present research interest focuses on the use of heat in the treatment of cancer and making efforts in establishing hyperthermia as an independent therapy system to treat cancerous cells. Her Lab mission is to accelerate the study of cancer therapy through developing a broad range of impactful nanosystems that can be used to detect, monitor, or enhance cancer treatment. Area of particular focus is hyperthermia and its contribution towards cancer prevention. Her multidisciplinary team is also working on the downstream processing of natural anticancer bioactives, mimicking tumor microenvironment through biochips and the role as well as risks of other barrier contributing to cancer treatment.

  • Our focus is on cancer diagnostics and therapies by developing multifunctional targeted nanoparticles capable of tumor imaging, controlled drug release, hyperthermia, and combined cancer treatments.

  • We are specialized in magnetic hyperthermia, using heat generated by magnetic nanoparticles for cancer treatment, aiming to establish it as an independent therapeutic modality.

Current Group Members

  • UTTKARSH KATIYAR

    UTTKARSH KATIYAR

    Email: uttkarsh.ph23233@inst.ac.in

    Reg. No.: PH23233

  • MS. NEETA DEVI

    MS. NEETA DEVI

    Email: neeta.ph22230@inst.ac.in

    Reg. No.: PH22230

  • MS. RITU SHARMA

    MS. RITU SHARMA

    Email: ritu.ph22207@inst.ac.in

    Reg. No.: PH22207

  • NANDINI BAJAJ

    NANDINI BAJAJ

    Email: nandini.ar200802@inst.ac.in

    Reg. No.: 10BB20A67002

  • AMIT B TEWARI

    AMIT B TEWARI

    Email: amit.ph20203@inst.ac.in

    Reg. No.: PH20203

  • MS. VISHAKHA

    MS. VISHAKHA

    Email: vishakha.ph21229@inst.ac.in

    Reg. No.: PH21229

  • MS. PRIYANKA

    MS. PRIYANKA

    Email: priyanka.ph17230@inst.ac.in

    Reg. No.: PH17230

Alumni

  • MS. TASHMEEN KAUR

    MS. TASHMEEN KAUR

    Reg. No.: PH19232

    Designation: PhD Scholar

    Jan 2020 - Mar 2025

  • ANAMIKA SAINI

    ANAMIKA SAINI

    Reg. No.: IN2021-4

    Designation: Intern Student

    Jul 2021 - Dec 2022

  • DR ANJALI CHAUHAN

    DR ANJALI CHAUHAN

    Reg. No.: RA202114

    Designation: Post Docs/RA

    Jun 2021 - Oct 2022

  • RUBY GUPTA

    RUBY GUPTA

    Reg. No.: PH16201

    Designation: PhD Scholar

    Aug 2016 - Apr 2022

  • AMIT B TEWARI

    AMIT B TEWARI

    Reg. No.: RP571923

    Designation: Project JRF/SRF

    Dec 2019 - Aug 2020

  • 1.

    Microbiota-Mediated Modulation of Chemotherapeutic Drug Efficacy in Colorectal Cancer: An In-Depth Analysis of Six Key Drugs , Priyanka Dalal, Nandini Bajaj, Uttkarsh Katiyar, Deepika Sharma , Molecular Pharmaceutics , 2025 , https://doi.org/10.1021/acs.molpharmaceut.5c00587

  • 2.

    Denticity Modulation of a Bioinspired Indole-Based CNP Donor Ligand toward Pd(II): Structural, DFT, Hirshfeld Surface Analysis, and Potent In Vitro Cytotoxicity against Breast Cancer 4T1 Cells , Jugmendra Singh, Tashmeen Kaur, Naresh Kumar, Deepika Sharma, and Umesh Kumar , Organometallics , 2025 , https://doi.org/10.1021/acs.organomet.5c00119

  • 3.

    Netrin-slaying nanoparticles: A new frontier in cancer therapy , Vishakha Sherawat, Deepika Sharma , BBA Advances , 2025 , https://doi.org/10.1016/j.bbadva.2025.100163

  • 4.

    E. coli as a Smart Thermo-Vector for Combating Solid Tumors: A Synergistic Heat-Induced Cancer Therapy Approach , Tashmeen Kaur, Neeta Devi, Deepika Sharma , Bioconjugate Chemistry , 2025 , https://doi.org/10.1021/acs.bioconjchem.5c00102

  • 5.

    Inorganic–organic γ-octamolybdate hybrids for targeted anticancer applications against MiaPaca-2 and A549 cells , Ankita Pardiwala, Nandini Bajaj , Arup Kumar Ghosh, Deepika Sharma, Komal Kumar Jangir and Ritambhara Jangir , Journal of Materials Chemistry B , 2025 , https://doi.org/10.1039/D5TB01422K

  • 6.

    The evolution of integrated magnetic hyperthermia and chemodynamic therapy for combating cancer: a comprehensive viewpoint , Anjali Chauhan, Anamika Saini and Deepika Sharma , Nanoscale Advances , 2025 , 2025 , 10.1039/D4NA01004C

  • 7.

    Self-propelling bacteria-based magnetic nanoparticles (BacMags) for targeted magnetic hyperthermia therapy against hypoxic tumors , Tashmeen Kaur ,Deepika Sharma , Nanoscale , 2024 , 16 , DOI https://doi.org/10.1039/D3NR05082C

  • 8.

    Enhancing Magnetic Hyperthermia Efficacy through Targeted Heat Shock Protein 90 Inhibition: Unveiling Immune-Mediated Therapeutic Synergy in Glioma Treatment , Ruby Gupta, Anjali Chauhan, Tashmeen Kaur, Bijoy Kumar Kuanr, and Deepika Sharma , ACS Nano , 2024 , https://doi.org/10.1021/acsnano.4c03887

  • 9.

    Extirpating the cancer stem cell hydra: Differentiation therapy and Hyperthermia therapy for targeting the cancer stem cell hierarchy , Amit B Tewari, Anamika Saini,Deepika Sharma , Clinical and Experimental Medicine , 2023 , https://doi.org/10.1007/s10238-023-01066-5

  • 10.

    Enzymatic synthesis of cellulose nanocrystals from lemongrass and its application in improving anti-cancer drug release, uptake and efficacy , Priyanka Kumari, Richa Seth, Abha Meena, Deepika Sharma , Industrial Crops and Products , 2023 , Volume 192 , 115933 , https://doi.org/10.1016/j.indcrop.2022.115933

  • 11.

    Nickel Complexes Bearing ONS Chelating Ligands: A Promising Contender for In Vitro Cytotoxicity Effects on Human Pancreatic Cancer MIA-PaCa-2 Cells , Deepika Tanwar, Tashmeen Kaur, Robin Kumar, Deepali Ahluwalia, Deepika Sharma, and Umesh Kumar , ACS Applied Bio Materials , 2023 , 6 (1) , 134-145 , 10.1021/acsabm.2c00787

  • 12.

    Magnetic hyperthermia cancer therapy using rare earth metal-based nanoparticles: An investigation of Lanthanum strontium Manganite's hyperthermic properties , Amit B Tewari, Ritu Sharma, Deepika Sharma , Results in Engineering , 2023 , 101537 , https://doi.org/10.1016/j.rineng.2023.101537

  • 13.

    Vitamin k3-Loaded Magnetic Nanoparticle-Mediated Synergistic Magnetothermodynamic Therapy Evokes Massive ROS and Immune Modulation for Augmented Antitumor Potential , Anjali Chauhan, Km Anjaly, Anamika Saini, Ravi Kumar, Bijoy K. Kuanr, and Deepika Sharma , ACS Applied Materials & Interfaces , 2023 , 5 (23) , 27515-27532 , 10.1021/acsami.3c01702

  • 14.

    Evolution of Magnetic Hyperthermia for Glioblastoma Multiforme Therapy: , Ruby Gupta, Deepika Sharma , 2019) , 0(3): 1157-1172 , ACS Chemical Neuroscience , 10.1021/acschemneuro.8b00652

  • 15.

    Indispensable role of microbes in anticancer drugs and discovery trends: , Ridham Kapoor, Anamika Saini, Deepika Sharma , (2022) , Appl Microbiol Biotechnol , https://doi.org/10.1007/s00253-022-12046-2

  • 16.

    Transmigration of magnetite nanoparticles across the blood-brain barrier in a rodent model: Influence of external and alternating magnetic field : , Ruby Gupta, Anjali Chauhan, Tashmeen Kaur, Bijoy Kumar Kuanr Sharma, Deepika , (2022) , Nanoscale , https://doi.org/10.1039/D2NR02210A

  • 17.

    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer’s disease: , Bhupinder Kapoor, Monika Gulati, Pooja Rani, Rajpal Singh Kochhar, Atanas G. Atanasov, Reena Gupta, Deepika Sharma, Deepak Kapoor , (2022) , BioFactors , https://doi.org/10.1002/biof.1910

  • 18.

    Green synthesis of biocompatible superparamagnetic iron oxide-gold composite nanoparticles for magnetic resonance imaging, hyperthermia and photothermal therapeutic applications: , Sharad Gupta , Prashant Kharey, Manish Goel, Zakir Husain, Ruby Gupta, Deepika Sharma,Manikandan M, I.A.Palani , (2022) , 293: 126859 , Materials Chemistry and Physics , https://doi.org/10.1016/j.matchemphys.2022.126859

  • 19.

    Expansion of thermometry in magnetic hyperthermia cancer therapy: antecedence and aftermath: , Tashmeen Kaur , Deepika Sharma , (2022) , Nanomedicine: Future Medicine , https://doi.org/10.2217/nnm-2022-0095

  • 20.

    Deciphering the Interdependent Labyrinth between Gut Microbiota and the Immune System: , Anamika Saini, Priyanka Dalal, Deepika Sharma , (2022) , Letters in Applied Microbiology , https://doi.org/10.1111/lam.13775

  • 21.

    Tailoring nanoparticles design for enhanced heating efficiency and improved magneto-chemo therapy for glioblastoma: , RubyGupta, Tashmeen Kaur, Anjali Chauhan, Ravi Kumar, Bijoy K Kuanr, Deepika Sharma , (2022) , 139: 213021 , Biomaterials Advances , https://doi.org/10.1016/j.bioadv.2022.213021

  • 22.

    Near-infrared active superparamagnetic iron oxide nanoparticles for magnetomotive optical coherence tomography imaging and magnetic hyperthermia therapeutic applications: , PrashantKharey,Abhishek Indoliya,RubyGupta,RajuPoddar,Deepika Sharma,SharadGupta , (2022) , 549: 169038 , Journal of Magnetism and Magnetic Materials , https://doi.org/10.1016/j.jmmm.2022.169038

  • 23.

    Carboxymethyl-stevioside)-coated magnetic dots for enhanced magnetic hyperthermia and improved glioblastoma treatment: , Deepika Sharma,Ruby Gupta, , (2021) , 205: 111870 , Colloids and Surfaces B: Biointerfaces , https://doi.org/10.1016/j.colsurfb.2021.111870

  • 24.

    Effect of manganese doping on the hyperthermic profile of ferrite nanoparticles using response surface methodology: , Ruby Gupta, Ruchi Tomar,Suvankar Chakraverty,Deepika Sharma , (2021) , 11: 16942-16954 , RSC Advances , 10.1039/D1RA02376D

  • 25.

    Therapeutic response differences between 2D and 3D tumor models of magnetic hyperthermia: , Ruby Gupta,Deepika Sharma , (2021) , Nanoscale Advances , 10.1039/D1NA00224D

  • 26.

    In Vitro Anti-tumoral and Anti-bacterial Activity of an Octamolybdate Cluster-Based Hybrid Solid Incorporated with a Copper Picolinate Complex: , Joshi A,Gupta R,Vaghasiya K,Verma R.K,Sharma D,Singh M , (2021) , 3(7): 4025–4035 , ACS Applied Bio Materials , https://doi.org/10.1021/acsabm.0c00093

  • 27.

    Microbe defines the efficacy of chemotherapeutic drug: a complete paradigm : , Priyanka Dalal,Deepika Sharma, , (2021) , 368:. , FEMS Microbiology letters , https://doi.org/10.1093/femsle/fnab116

  • 28.

    Near-infrared-responsive silver-capped magnetic nanoclusters for cancer therapy : , Tewari A,Gupta R,Sharma D , (2020) , 11: 45-51 , Journal of Radiation and Cancer Research , https://doi.org/10.4103/jrcr.jrcr_19_20

  • 29.

    Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid: , Arti Joshi,Ruby Gupta,Bharti Singh,Deepika Sharma,Monika Singh , (2020) , 49: 7069-7077 , Dalton Trans , https://doi.org/10.1039/D0DT01042A

  • 30.

    Manganese-Doped Magnetic Nanoclusters for Hyperthermia and Photothermal Glioblastoma Therapy : , Ruby Gupta and Deepika Sharma , (2020) , 3: 2026-2037 , ACS Applied Nano Materials , 10.1021/acsanm.0c00121

  • 31.

    First report of isolation of Aeromonas taiwanensis from India : , Nanda T,Sharma D , (2020) , 36: 100721 , New Microbes and New Infections , https://doi.org/10.1016/j.nmni.2020.100721

  • 32.

    Formation of diamond nanostructures from graphite using 10 W fibre laser : , Verma A,Prakash B,Sharma D , (2020) , 43(1): 1-5 , Bulletin of Materials Science , https://doi.org/10.1007/s12034-020-02255-8

  • 33.

    Biomineralized and Chemically Synthesized Magnetic Nanoparticles: A Contrast : , Nanda T,Rathode A,Sharma D , (2020) , 14(4): 387–401 , Frontiers of Materials Science , https://doi.org/10.1007/s11706-020-0531-7

  • 34.

    A Mo(vi) based coordination polymer as an antiproliferative agent against cancer cells: , Arti Joshi,Ruby Gupta,Deepika Sharma,Monika Singh , (2020) , 50: 1253-1260 , Dalton Transactions , http://dx.doi.org/10.1039/D0DT03865B

  • 35.

    Cellulose nanofibers from lignocellulosic biomass of lemongrass using enzymatic hydrolysis: characterization and cytotoxicity assessment: , Priyanka Kumari, Gauri Pathak,Ruby Gupta, Deepika Sharma,Abha Meena , (2019) , 27: 683–693 , DARU Journal of Pharmaceutical Sciences , https://doi.org/10.1007/s40199-019-00303-1

  • 36.

    Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications : , Ruby Gupta , (2019) , 36(1): 302-312 , International Journal of Hyperthermia , 10.1080/02656736.2019.1565787

  • 37.

    Biocompatible ferrite nanoparticles for hyperthermia: effect of polydispersity, anisotropy energy and inter-particle interaction: , Neha Wadhera, Ruby Gupta,Bhanu Prakash,D Sharma,Suvankar , (2017) , 4: 025037 , Materials Research Express , 10.1088/2053-1591/aa5d93

  • 38.

    The Inhibitory Effect of Stevioside on Bacillus cereus Growth in Milk: Validation and its Response Surface Optimization: , Munish Puri, Deepika Sharma , (2015) , 4(1): 56-64 , Current Biotechnology , 10.2174/2211550104666150423000314

  • 39.

    Enzyme assisted extraction of bioactives from plants.: , Munish Puri,Collin J. Barrow , (2012) , 30(1): 37-44 , Trends in Biotechnology , 10.1016/j.tibtech.2011.06.014

  • 40.

    Optimization of novel method for the extraction of stevioside from Stevia rebaudianaleaves: , Munish Puri, Collin J Barrow, Ashok K Tiwary , (2012) , 132(3): 1113-1120 , Food Chemistry , 10.1016/j.foodchem.2011.11.063

  • 41.

    Antibacterial activity of stevioside towards food borne pathogenic bacteria: , Munish Puri , (2011) , 11(3): 326-329 , Engineering in Life Science , 10.1002/elsc.201000142

  • 42.

    Downstream processing of stevioside and its potential applications: , Munish Puri,Ashok K Tiwary , (2011) , 29(6): 781-79 , Biotechnology Advances , 10.1016/j.biotechadv.2011.06.006

  • 43.

    Antiamnesic effect of stevioside in scopolamine-treated rats: , Deepika Sharma , Munish Puri, Ashok K Tiwary, Nirmal Singh, Amteshwar Singh Jaggi , (2010) , 42(3): 164 , Indian journal of pharmacology , 10.4103/0253-7613.66840

  • 44.

    Anti-Inflammatory Potential of Curcumin: From Chemistry and Mechanistic Insight to Nanoformulations , Diwakar Aggarwal, Mayank Chaudhary, Nandini Bajaj, Deepika Sharma, Sushil Kumar Upadhyay, Vivek Kumar Garg, Hadi Sajid Abdulabbas, Hardeep Singh Tuli, Isha Rani , Current Bioactive Compounds , 20 , 10-20 , https://doi.org/10.2174/1573407219666230726164538

  • 45.

    Uncovering metabolic signatures in cancer-derived exosomes: LC-MS/MS and NMR profiling , Nandini bajaj, deepika sharma , nanoscale , 17 , 287-303 , https://doi.org/10.1039/D4NR03454F

  • 1.

    Multifunctional Bioactives- Nano-sized Delivery Systems for Cancer. In: Food Bioactives Extraction and Biotechnology Applications: , Springer Comm , (2017) , Ch12: 299-323

  • Scientist D: Institute of Nano Science and Technology, Knowledge City, Sector 81, Mohali-140306, Punjab, India. (January 2022 to Present till date )

    Scientist C: Institute of Nano Science and Technology, Phase 10, Sector 64, Mohali 160062, Punjab, India (January 2019 to December 2021 )

    Scientist B: Institute of Nano Science and Technology, Phase 10, Sector 64, Mohali 160062, Punjab, India (January 2015 to December 2018 )

    DBT Research Associate: Institute of Nano Science and Technology, Phase 10, Sector 64, Mohali 160062, Punjab, India (July 2013 to December 2014 )

    Lecturer: Department of Biotechnology, Multani Mal Modi College, Patiala, Punjab, India. (April 2011 to June 2013 )

  • Excellence Presentation Award in the field of biology and Chemistry in InternationaLCongress of Hyperthermia Oncology 2025 at Seoul, South Korea.

  • Department of Biotechnology (DBT) Research Associateship (2013-2015).

    Punjab State Scholarship for merit in Graduation (2005).

    Awarded by Roll of Honour during Graduation (2005).

    Member of Chandigarh Region Innovation and Knowledge Cluster (CRIKC)

    Member of Indian Association for Hyperthermic Oncology and Medicine (IAHOM)

    Member of Indian Association of Cancer Research (IACR)

    Member of Biotech Research Society of India (BRSI)

  • Title: Temozolomide delivery across blood brain barrier through nanomagnetic transducer: A targeted therapy for Glioblastoma multiforme

    PI: Dr. Deepika Sharma

    Tenure: 2019-2021

    Funding Agency: SERB, DST

  • Title: Magnetic Nanoparticles conjugated bacteria for chemo-thermo application

    PI: Dr Deepika Sharma

    Funding Amount: 16.4 Lakhs

    Funding Agency: CSIR

    Additional Info: 01/3134/23/EMRII

  • Title: Development and Clinical Validation of an Affordable and Point of Care Microfluidic Chip for Early Detection of Metastatic Breast Cancer using Hairpin Loop Converter and Proximity Proteolysis Reaction: A Pilot Study

    PI: Dr. Deepika Sharma

    Funding Amount: 78.6 Lakhs

    Tenure: 2024

    End Date: 01-Oct-2027

    Funding Agency: DBT

  • Title: Netrin-1 Centric Precision Therapy for Cervical Cancer Treatment by Integrating Computer Modelling, Experimental Methods, and Nano formulation with Protein- ligand Interactions.

    PI: Dr. Deepika Sharma

    Funding Amount: 80 Lakhs

    Tenure: 2024-2027

    Funding Agency: ICMR