Faculty Directory

Dr. Prakash P. Neelakandan

Scientist 'F' (Professor), Head of the Unit

Our research group is focused on using synthetic organic chemistry to prepare new organic functional materials for applications in flexible electronic devices, sensors and cancer therapeutics.

CONTACT INFORMATION :

Research Interest

  • Photoactive Organic Soft Materials


    Our research group is focused on using synthetic organic chemistry to prepare new organic compounds and their composite materials. We have well-established laboratories and instrumentation facilities for the synthesis, characterization and studying the photochemical and photophysical properties of the newly synthesized functional materials.


    The major ongoing projects include studying plasmon-molecule coupling in organic dye loaded metal nanoparticles, development of flexible organic single crystals, synthesis of novel luminescent organic materials and DNA analogues. These materials are then explored for applications in various fields ranging from cancer therapeutics to sensors and flexible electronic devices.

Research Highlights

  • Highly sensitive chemosensors have been developed for biologically relevant thiols and fluoride anions.
    Organic single crystals showing flexible optical waveguide and thermosalience have been developed.
    Our recent results help to understand the role of chemical structure in plasmon-molecule coupling.
    Dye-loaded metal nanoparticles find application as PDT and cellular imaging agents.

PhD Students

  • MR. AJAY KUMAR

    Email: ajay.ph21244@inst.ac.in

    Reg. No.: PH21244

    Working Since Jan, 2022
  • MS. KIRAN ARORA

    Email: kiran.ph21242@inst.ac.in

    Reg. No.: PH21242

    Working Since Jan, 2022
  • Ms. Parvati Marandi

    Email: parvati.ph17218@inst.ac.in

    Reg. No.: PH17218

    Working Since Jan, 2018
  • Mr. Hemant

    Email: hemant.ar210106@inst.ac.in

    Reg. No.: 10BB21J67006

    Working Since Jan, 2021
  • MS. AYUSHI NAGPAL

    Email: ayushi.ph20232@inst.ac.in

    Reg. No.: PH20232

    Working Since Aug, 2020
  • Mr. ATIKUR RAHMAN

    Email: atikur.ph16238@inst.ac.in

    Reg. No.: PH16238

    Working Since Jan, 2017
  • Ms. Sanchita Shah

    Email: sanchita.ph16229@inst.ac.in

    Reg. No.: PH16229

    Working Since Jan, 2017

Research Associates

  • Khalid Naim

    Email: khalid.ph16222@inst.ac.in

    Reg. No.: RA-01-202132

    Working Since Feb, 2022

Project - JRF/SRF

  • Ms. Suman R. Mallah

    Email: email@inst.ac.in

    Reg. No.: RP261823


Post Doc Fellows

  • Dr. P. P. Praveen Kumar

    Email: email@inst.ac.in

    Reg. No.: NPDF1709


  1. Molecular Logic Operations using Multi-stimuli Responsive, Mechanically Tunable Elastic Organic Single Crystals: P Marandi, K Naim, K Parida, PP Neelakandan*, (2022) ACS Mater. Lett., 4: 2499-2505. DOI: 10.1021/acsmaterialslett.2c00889

  2. Hot Electron Migration from Gold Nanoparticle to an Organic Molecule Enhances Luminescence and Photosensitization Properties of a pH Activatable Plasmon-Molecule Coupled Nanocomposite: A Rahman, T Goswami, N Tyagi, HN Ghosh*, PP Neelakandan*, (2022) J. Photochem. Photobiol. A: Chem, 432: 114067. DOI: 10.1016/j.jphotochem.2022.114067

  3. Isomer Selective Thermosalience and Luminescence Switching in Organic Crystals: K Naim, SC Sahoo,PP Neelakandan*, (2022) ACS Appl. Mater. Interfaces, 14: 22650-22657. DOI: 10.1021/acsami.2c05053

  4. Gold–BODIPY Nanoparticles with Luminescence and Photosensitization Properties for Photodynamic Therapy and Cell Imaging: A Rahman, PPP Kumar, P Yadav, T Goswami, A Shanavas*, HN Ghosh*, PP Neelakandan*, (2022) ACS Appl. Nano Mater., 5: 6532-6542. DOI: 10.1021/acsanm.2c00616

  5. Aggregation-Induced Emission, Mechanofluorochromism, and Selective Fluoride Detection by a Tripodal Salicylaldimine: P Marandi,N Tyagi,PP Neelakandan*, (2022) ChemPlusChem, 87: e202100555. DOI: 10.1002/cplu.202100555

  6. Advances in the Supramolecular Chemistry of Tetracoordinate Boron-containing Organic Molecules into Organogels and Mesogens: S Shah, P Marandi, PP Neelakandan*, (2021) Front. Chem., 9: 708854. DOI: 10.3389/fchem.2021.708854

  7. Remarkable Self-assembly of Salicylideneimine-Boron Complexes into Plastic Crystals and Organogels: K Naim, SC Sahoo, P Venugopalan, PP Neelakandan*, (2021) Cryst. Growth Des., 21: 3798-3806. DOI: 10.1021/acs.cgd.1c00132

  8. Fine‐Tuning Plasmon‐Molecule Interactions in Gold‐BODIPY Nanocomposites: The Role of Chemical Structure and Noncovalent Interactions: PPP Kumar, A Rahman, T Goswami, HN Ghosh*, PP Neelakandan*, (2021) ChemPlusChem, 86: 87-94. DOI: 10.1002/cplu.202000545

  9. Exceptionally Plastic/Elastic Organic Crystals of a Naphthalidenimine‐Boron Complex Show Flexible Optical Waveguide Properties: K Naim, M Singh, S Sharma, RV Nair, P Venugopalan*, SC Sahoo*, PP Neelakandan*, (2020) Chem. Eur. J., 26: 11979-11984. DOI: 10.1002/chem.202002641

  10. Synthesis and Anti‐Proliferative Activity of a Triazole‐Fused Thymidine Analogue: A Rahman, P Sharma, N Kaur, A Shanavas*, and PP Neelakandan*, (2020) ChemistrySelect, 5: 5473-5478. DOI: 10.1002/slct.202001013

  11. Aggregation Enhances Luminescence and Photosensitization Properties of a Hexaiodo-BODIPY: PPP Kumar, P Yadav, A Shanavas, and PP Neelakandan*, (2020) Mater. Chem. Front., 4: 965-972. DOI: 10.1039/D0QM00010H

  12. Nanomolar Detection of Biothiols via Turn-ON Fluorescent Indicator Displacement: PPP Kumar, N Kaur, A Shanavas, and PP Neelakandan*, (2020) Analyst, 145: 851-857. DOI: 10.1039/C9AN02222H

  13. Selective Metal-ion Detection and Activatable Photosensitization Properties of a Tetraphenylethylene based Salicylideneimine: P Marandi, PPP Kumar, P Venugopalan, and PP Neelakandan*, (2019) ChemistrySelect, 4: 5707-5713. DOI: 10.1002/slct.201901035

  14. A Three-Component Supramolecular Nanocomposite as a Heavy-Atom-Free Photosensitizer: PPP Kumar, P Yadav, A Shanavas, S Thurakkal, J Joseph, and PP Neelakandan*, (2019) Chem. Commun., 55: 5623-5626. DOI: 10.1039/C9CC02480H

  15. Iodo-functionalized Salicylideneimine-Boron Complexes: Synthesis and Photosensitized Degradation of Organic Water Pollutants: S Shah, A Bajaj, A Shibu, ME Ali*, and PP Neelakandan*, (2018) Chem. Eur. J., 24: 18788-18794. DOI: 10.1002/chem.201804376

  16. Supramolecular confinement within chitosan nanocomposites enhance singlet oxygen generation: K Naim, S T Nair, P Yadav,A Shanavas, P P Neelakandan, (2018) ChemPlusChem, 83: 418 –422.. DOI: /10.1002/cplu.201800041

  17. Excitation energy delocalization and transfer to guests within M4L6 cage frameworks: AJ Musser,† PP Neelakandan,† JM Richter, H Mori, RH Friend*, and JR Nitschke*, (2017) J. Am. Chem. Soc., 139: 12050-12059.. DOI: 10.1021/jacs.7b06709

  18. An autocatalytic system of photooxidation-driven substitution reactions on a FeII4L6 cage framework: PP Neelakandan, A Jiménez, JD Thoburn, JR Nitschke*, (2015) Angew. Chem. Int. Ed., 127: 14586-14590. DOI: 10.1002/anie.201507045

  19. Simultaneous binding of a cyclophane and classical intercalators to DNA: Observation of FRET-mediated white light emission: KS Sanju, S Thurakkal, PP Neelakandan, J Joseph, D Ramaiah*, (2015) Phys. Chem. Chem. Phys., 17: 13495-13500. DOI: 10.1039/C5CP00208G

  20. Stimuli responsive metal-ligand assemblies: AJ McConnell,† CS Wood,† PP Neelakandan,† JR Nitschke*, (2015) Chem. Rev, 115: 7729-7793. DOI: 10.1021/cr500632f

  21. Ground and excited state electronic spectra of perylenediimide dimers with flexible and rigid geometries in DNA conjugates: T. A Zeidan, M. McCullagh, G. C. Schatz, J. Vura-Weis, C. H. Kim, M. R. Wasielewski, F. D. Lewis, (2014) Chem. Sci., 5: 973-981. DOI: 10.1039/C3SC52908H

  22. Fluorophore incorporation allows nanomolar guest sensing and white-light emission in M4L6 cage complexes: PP Neelakandan, A Jiménez, JR Nitschke*, (2014) Chem. Sci., 5: 908-915. DOI: 10.1039/C3SC53172D

  23. Interplay of monomer, intra- and intermolecular excimer fluorescence in cyclophanes and selective recognition of methanol vapours: PC Nandajan, PP Neelakandan, D Ramaiah*, (2013) RSC Adv., 3: 5624-5630. DOI: 10.1039/C3RA21678K

  24. Facially-selective thymine-thymine photodimerization in TTT triads: PP Neelakandan, Z Pan, M Hariharan, FD Lewis*, (2012) Photochem. Photobiol. Sci., 11: 889-892. DOI: C2PP25089F

  25. Electronic interactions in helical stacked arrays of the modified DNA base pyrrolocytosine: PP Neelakandan, M McCullagh, GC Schatz, FD Lewis*, (2012) J. Phys. Chem. B, 116: 5199-5204. DOI: 10.1021/jp302385c

  26. DNA-assisted white light emission through FRET: KS Sanju, PP Neelakandan, D Ramaiah*, (2011) Chem. Commun., 47: 1288-1290. DOI: 10.1039/C0CC04173D

  27. Study of cavity size and nature of bridging units on recognition of nucleotides by cyclophanes: PP Neelakandan, PC Nandajan, B Subymol, D Ramaiah*, (2011) Org. Biomol. Chem., 9: 1021-1029. DOI: 10.1039/C0OB00673D

  28. Hydrophobic self-assembly of a perylenediimide-linked DNA dumbbell into supramolecular polymers: PP Neelakandan, Z Pan, M Hariharan, Y Zheng, H Weissman, B Rybtchinski*, FD Lewis*, (2010) J. Am. Chem. Soc, 132: 15808-15813. DOI: 10.1021/ja1076525

  29. Functional cyclophanes: Promising hosts for optical biomolecular recognition: D. Ramaiah*, PP Neelakandan, AK Nair, RR Avirah, (2010) Chem. Soc. Rev., 39: 4158-4168.. DOI: 10.1039/B920032K

  30. Effect of bridging units on photophysical and DNA binding properties of a few cyclophanes: PP Neelakandan, KS Sanju, D Ramaiah*, (2010) Photochem. Photobiol., 86: 282-289. DOI: 10.1111/j.1751-1097.2009.00660.x

  31. A supramolecular Cu(II) metallocyclophane probe for guanosine 5’-monophosphate: AK Nair, PP Neelakandan, D Ramaiah*, (2009) Chem. Commun., 2009: 6352-6354. DOI: 10.1039/B911855A

  32. DNA assisted long lived excimer formation in a cyclophane: PP Neelakandan, D Ramaiah*, (2008) Angew. Chem. Int. Ed., 47: 8407-8411. DOI: 10.1002/anie.200803162

  33. Encapsulation of electron donor-acceptor dyads in β-CD cavity: Unusual planarization and enhancement in rate of electron transfer reaction: M Hariharan, PP Neelakandan, D Ramaiah*, (2007) J. Phys. Chem. B, 111: 11940-11947. DOI: 10.1021/jp074643d

  34. A supramolecular ON-OFF-ON fluorescence assay for selective recognition of GTP: PP Neelakandan, M Hariharan, D Ramaiah*, (2006) J. Am. Chem. Soc, 128: 11334-11335. DOI: 10.1021/ja062651m

  35. Synthesis of a Novel Cyclic Donor−Acceptor Conjugate for Selective Recognition of ATP: PP Neelakandan, M Hariharan, D Ramaiah*, (2005) Org. Lett., 7: 5765-5768. DOI: 10.1021/ol052246k

  1. Photoactive Finite Supramolecular Coordination Cages for Photodynamic Therapy: N Tyagi, PP Neelakandan*, (2022) Supramolecular Coordination Complexes: Design, Synthesis, and Applications, 2023: Elsevier. DOI: ISBN: 9780323905824

Fundings

  • Dynamic Self-assembled Nucleic Acid Analogues 3 years, DBT
    Funding Amount: -
    PI: Dr. Prakash P. Neelakandan Co-PI: Dr. Asifkhan Shanavas
  • Organoboron Macrocycles as Adaptable, Photoactive Materials 3 years, SERB
    Funding Amount: -
    PI: Dr. Prakash P. Neelakandan

  • 2001

    B. Sc.

    Sacred Heart College, Kochi, Kerala

  • 2009

    Ph. D.

    CSIR-NIIST Thiruvananthapuram.

  • 2003

    M. Sc.

    Sacred Heart College, Kochi, Kerala

  • Professor (Scientist F):Institute of Nano Science and Technology, Mohali, India. (January 2021 to Present till date )

  • Associate Professor (Scientist E):Institute of Nano Science and Technology, Mohali, India. (April 2015 to December 2020 )

  • Postdoctoral Research Associate:University of Cambridge, UK (May 2012 to March 2015 )

  • Postdoctoral Fellow:Northwestern University, Evanston, IL, USA. (July 2009 to April 2012 )

Awards & Honours

  • INSPIRE Faculty Award by DST, Government of India in February 2013 (not availed).

  • SERC Bio-inorganic Pre-doctoral Fellowship awarded by DST, Government of India in October 2006.




Professional Recognitions