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Scientist 'F' (Professor)
Photoactive supramolecular soft materials for applications in sensing and chemical biology
Boron-containing organic
compounds are a well-accepted class of compounds having excellent
photophysical properties. These molecules are synthesized by complexing
boron with organic chelates and are stabilized by the delocalization of
lone-pair electrons of the hetero-atoms of the chelates into the vacant
p-orbital on boron. Apart from the unique photophysical properties, the
ease of synthesis and structural robustness make boron-containing
molecules ideal for a variety of applications. We follow a simple
self-assembly based pathway for the synthesis of boron containing
molecules and use commercially available starting materials thereby
minimising the number of synthetic steps. We have been successful in
synthesising a variety of functionalized molecules for optoelectronics
and biological applications such as flexible optical wave-guiding,
anti-counterfeiting, sensing, water purification and photodynamic
therapy.
Plasmon-molecule
coupling has emerged as a new modality for the development of photonic
devices and optically responsive materials. Metal nanoparticles in
combination with dyes provide a platform to construct hybrid materials
whose photophysical properties may be tuned at the nanoscale. Molecules
which absorb light near to the surface plasmon resonance absorption peak
of metal nanoparticles can induce changes in the photophysical and
electronic properties of metal nanoparticles through plasmon-molecule
interactions. We prepare nanocomposites of common dye molecules using
metal nanoparticles and study their photophysical and photochemical
properties. We have shown that by systematically varying the
functionalities on the dye molecules it is possible to modulate the
photophysical and photochemical properties of the nanocomposites and
allowed them to be used as photosensitizers for photodynamic therapy and
as sensors for biologically relevant substrates.
Synthetic
nucleic acids are widely used in fundamental research and also for
applications in medical diagnosis and drug development. Some of them
have been commercialized as drugs and several are undergoing clinical
trials. We aim to develop new analogues of nucleosides and nucleic acids
for therapeutic applications. We have shown that nucleoside analogues
containing the hydrogen bonding face of the natural bases can be
synthesized and that these molecules exhibit anti-cancer activity. We
are also interested in developing new methodologies based on
supramolecular chemistry to synthesize nucleic acid analogues which will
add a new dimension to the nucleic acid chemistry.
Research in Prakash Neelakandan's group focuses on the development of photoactive soft nanomaterials through self-assembly mediated methodologies. Organoboron compounds, dye-loaded metal nanocomposites and nucleic acid analogues are developed for applications in sensing and chemical biology.
Email: ajay.ph21244@inst.ac.in
Reg. No.: PH21244
Email: kiran.ph21242@inst.ac.in
Reg. No.: PH21242
Email: parvati.ph17218@inst.ac.in
Reg. No.: PH17218
Email: hemant.ar210106@inst.ac.in
Reg. No.: 10BB21J67006
Email: ayushi.ph20232@inst.ac.in
Reg. No.: PH20232
Email: khalid.ph16222@inst.ac.in
Reg. No.: PH16222
Email: atikur.ph16238@inst.ac.in
Reg. No.: PH16238
Email: sanchita.ph16229@inst.ac.in
Reg. No.: PH16229
Email: email@inst.ac.in
Reg. No.: RP261823
Email: email@inst.ac.in
Reg. No.: NPDF1709
Advances in the Supramolecular Chemistry of Tetracoordinate Boron-containing Organic Molecules into Organogels and Mesogens: S Shah, P Marandi, PP Neelakandan*, (2021) Front. Chem., -: -. DOI: 10.3389/fchem.2021.708854
Remarkable Self-assembly of Salicylideneimine-Boron Complexes into Plastic Crystals and Organogels: K Naim, SC Sahoo, P Venugopalan, PP Neelakandan*, (2021) Cryst. Growth Des., 21: 3798-3806. DOI: 10.1021/acs.cgd.1c00132
Fine‐Tuning Plasmon‐Molecule Interactions in Gold‐BODIPY Nanocomposites: The Role of Chemical Structure and Noncovalent Interactions: PPP Kumar, A Rahman, T Goswami, HN Ghosh*, PP Neelakandan*, (2021) ChemPlusChem, 86: 87-94. DOI: 10.1002/cplu.202000545
Exceptionally Plastic/Elastic Organic Crystals of a Naphthalidenimine‐Boron Complex Show Flexible Optical Waveguide Properties: K Naim, M Singh, S Sharma, RV Nair, P Venugopalan*, SC Sahoo*, PP Neelakandan*, (2020) Chem. Eur. J., 26: 11979-11984. DOI: 10.1002/chem.202002641
Synthesis and Anti‐Proliferative Activity of a Triazole‐Fused Thymidine Analogue: A Rahman, P Sharma, N Kaur, A Shanavas*, and PP Neelakandan*, (2020) ChemistrySelect, 5: 5473-5478. DOI: 10.1002/slct.202001013
Aggregation Enhances Luminescence and Photosensitization Properties of a Hexaiodo-BODIPY: PPP Kumar, P Yadav, A Shanavas, and PP Neelakandan*, (2020) Mater. Chem. Front., 4: 965-972. DOI: 10.1039/D0QM00010H
Nanomolar Detection of Biothiols via Turn-ON Fluorescent Indicator Displacement: PPP Kumar, N Kaur, A Shanavas, and PP Neelakandan*, (2020) Analyst, 145: 851-857. DOI: 10.1039/C9AN02222H
Selective Metal-ion Detection and Activatable Photosensitization Properties of a Tetraphenylethylene based Salicylideneimine: P Marandi, PPP Kumar, P Venugopalan, and PP Neelakandan*, (2019) ChemistrySelect, 4: 5707-5713. DOI: 10.1002/slct.201901035
A Three-Component Supramolecular Nanocomposite as a Heavy-Atom-Free Photosensitizer: PPP Kumar, P Yadav, A Shanavas, S Thurakkal, J Joseph, and PP Neelakandan*, (2019) Chem. Commun., 55: 5623-5626. DOI: 10.1039/C9CC02480H
Iodo-functionalized Salicylideneimine-Boron Complexes: Synthesis and Photosensitized Degradation of Organic Water Pollutants: S Shah, A Bajaj, A Shibu, ME Ali*, and PP Neelakandan*, (2018) Chem. Eur. J., 24: 18788-18794. DOI: 10.1002/chem.201804376
Supramolecular confinement within chitosan nanocomposites enhance singlet oxygen generation: K Naim, S T Nair, P Yadav,A Shanavas, P P Neelakandan, (2018) ChemPlusChem, 83: 418 –422.. DOI: /10.1002/cplu.201800041
Excitation energy delocalization and transfer to guests within M4L6 cage frameworks: AJ Musser,† PP Neelakandan,† JM Richter, H Mori, RH Friend*, and JR Nitschke*, (2017) J. Am. Chem. Soc., 139: 12050-12059.. DOI: 10.1021/jacs.7b06709
An autocatalytic system of photooxidation-driven substitution reactions on a FeII4L6 cage framework: PP Neelakandan, A Jiménez, JD Thoburn, JR Nitschke*, (2015) Angew. Chem. Int. Ed., 127: 14586-14590. DOI: 10.1002/anie.201507045
Simultaneous binding of a cyclophane and classical intercalators to DNA: Observation of FRET-mediated white light emission: KS Sanju, S Thurakkal, PP Neelakandan, J Joseph, D Ramaiah*, (2015) Phys. Chem. Chem. Phys., 17: 13495-13500. DOI: 10.1039/C5CP00208G
Stimuli responsive metal-ligand assemblies: AJ McConnell,† CS Wood,† PP Neelakandan,† JR Nitschke*, (2015) Chem. Rev, 115: 7729-7793. DOI: 10.1021/cr500632f
Ground and excited state electronic spectra of perylenediimide dimers with flexible and rigid geometries in DNA conjugates: T. A Zeidan, M. McCullagh, G. C. Schatz, J. Vura-Weis, C. H. Kim, M. R. Wasielewski, F. D. Lewis, (2014) Chem. Sci., 5: 973-981. DOI: 10.1039/C3SC52908H
Fluorophore incorporation allows nanomolar guest sensing and white-light emission in M4L6 cage complexes: PP Neelakandan, A Jiménez, JR Nitschke*, (2014) Chem. Sci., 5: 908-915. DOI: 10.1039/C3SC53172D
Interplay of monomer, intra- and intermolecular excimer fluorescence in cyclophanes and selective recognition of methanol vapours: PC Nandajan, PP Neelakandan, D Ramaiah*, (2013) RSC Adv., 3: 5624-5630. DOI: 10.1039/C3RA21678K
Facially-selective thymine-thymine photodimerization in TTT triads: PP Neelakandan, Z Pan, M Hariharan, FD Lewis*, (2012) Photochem. Photobiol. Sci., 11: 889-892. DOI: C2PP25089F
Electronic interactions in helical stacked arrays of the modified DNA base pyrrolocytosine: PP Neelakandan, M McCullagh, GC Schatz, FD Lewis*, (2012) J. Phys. Chem. B, 116: 5199-5204. DOI: 10.1021/jp302385c
DNA-assisted white light emission through FRET: KS Sanju, PP Neelakandan, D Ramaiah*, (2011) Chem. Commun., 47: 1288-1290. DOI: 10.1039/C0CC04173D
Study of cavity size and nature of bridging units on recognition of nucleotides by cyclophanes: PP Neelakandan, PC Nandajan, B Subymol, D Ramaiah*, (2011) Org. Biomol. Chem., 9: 1021-1029. DOI: 10.1039/C0OB00673D
Hydrophobic self-assembly of a perylenediimide-linked DNA dumbbell into supramolecular polymers: PP Neelakandan, Z Pan, M Hariharan, Y Zheng, H Weissman, B Rybtchinski*, FD Lewis*, (2010) J. Am. Chem. Soc, 132: 15808-15813. DOI: 10.1021/ja1076525
Functional cyclophanes: Promising hosts for optical biomolecular recognition: D. Ramaiah*, PP Neelakandan, AK Nair, RR Avirah, (2010) Chem. Soc. Rev., 39: 4158-4168.. DOI: 10.1039/B920032K
Effect of bridging units on photophysical and DNA binding properties of a few cyclophanes: PP Neelakandan, KS Sanju, D Ramaiah*, (2010) Photochem. Photobiol., 86: 282-289. DOI: 10.1111/j.1751-1097.2009.00660.x
A supramolecular Cu(II) metallocyclophane probe for guanosine 5’-monophosphate: AK Nair, PP Neelakandan, D Ramaiah*, (2009) Chem. Commun., 2009: 6352-6354. DOI: 10.1039/B911855A
DNA assisted long lived excimer formation in a cyclophane: PP Neelakandan, D Ramaiah*, (2008) Angew. Chem. Int. Ed., 47: 8407-8411. DOI: 10.1002/anie.200803162
Encapsulation of electron donor-acceptor dyads in β-CD cavity: Unusual planarization and enhancement in rate of electron transfer reaction: M Hariharan, PP Neelakandan, D Ramaiah*, (2007) J. Phys. Chem. B, 111: 11940-11947. DOI: 10.1021/jp074643d
A supramolecular ON-OFF-ON fluorescence assay for selective recognition of GTP: PP Neelakandan, M Hariharan, D Ramaiah*, (2006) J. Am. Chem. Soc, 128: 11334-11335. DOI: 10.1021/ja062651m
Synthesis of a Novel Cyclic Donor−Acceptor Conjugate for Selective Recognition of ATP: PP Neelakandan, M Hariharan, D Ramaiah*, (2005) Org. Lett., 7: 5765-5768. DOI: 10.1021/ol052246k
Sacred Heart College, Kochi, Kerala
CSIR-NIIST Thiruvananthapuram.
Sacred Heart College, Kochi, Kerala
Associate Professor (Scientist-E):Institute of Nano Science and Technology, Mohali, India. (April 2015 to Present till date )
Postdoctoral Research Associate:University of Cambridge, UK (May 2012 to March 2015 )
Postdoctoral Fellow:Northwestern University, Evanston, IL, USA. (July 2009 to April 2012 )
INSPIRE Faculty Award by DST, Government of India in February 2013 (not availed).
SERC Bio-inorganic Pre-doctoral Fellowship awarded by DST, Government of India in October 2006.
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