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Dr. Rehan Khan

Scientist-D

Drug delivery systems for the management of Inflammatory Bowel disease and Rheumatoid Arthritis. Development of nano-sized particles for the therapy of Neurological disorders. Synthetic Lethality and Cancer - Targeted Therapy by Small Molecule Inhibitors/Nano-Formulations.

Contact Information :

  • Colorectal cancer is one of the greatest causes of cancer related mortalities on the global scale. In the context of cancer chemotherapy, synthetic lethality is a recent paradigm where interaction of two genes is explored, such that simultaneous inhibition or silencing of both the genes becomes lethal for the cancer cells while bearing least impact on the healthy cells. Our research deals with the formulation and characterization of novel nanoparticles for drug delivery purposes for synthetic lethal therapy mediated targeting of colorectal cancer. Most of the anti-cancer compounds have various limitations like solubility issues, poor bioavailability and off target effects which restrict their employability in the clinical platforms. To surpass these limitations, we develop customized nanoparticles for enhanced therapeutic efficacy and selective or targeted therapy of cancer. Our lab is focused on to develop inflammation-targeting carriers using biocompatible materials for the therapy of RA and UC.

  • Colorectal cancer is one of the greatest causes of cancer related mortalities on the global scale. In the context of cancer chemotherapy, synthetic lethality is a recent paradigm where interaction of two genes is explored, such that simultaneous inhibition or silencing of both the genes becomes lethal for the cancer cells while bearing least impact on the healthy cells. Our research deals with the formulation and characterization of novel nanoparticles for drug delivery purposes for synthetic lethal therapy mediated targeting of colorectal cancer. Most of the anti-cancer compounds have various limitations like solubility issues, poor bioavailability and off target effects which restrict their employability in the clinical platforms. To surpass these limitations, we develop customized nanoparticles for enhanced therapeutic efficacy and selective or targeted therapy of cancer.

Current Group Members

  • AJESH JOSHI

    AJESH JOSHI

    Email: ajesh.ph24207@inst.ac.in

    Reg. No.: PH24207

  • ASHRAF ALI

    ASHRAF ALI

    Email: ashraf.oh23239@inst.ac.in

    Reg. No.: PH23239

  • BHUVNESH KUMAR

    BHUVNESH KUMAR

    Email: bhuvnesh.ph23202@inst.ac.in

    Reg. No.: PH23202

  • MR. JATIN KUMAR

    MR. JATIN KUMAR

    Email: jatin.ph22237@inst.ac.in

    Reg. No.: PH22237

  • MR. SHUBHAM MAHAJAN

    MR. SHUBHAM MAHAJAN

    Email: shubham.ph22202@inst.ac.in

    Reg. No.: PH22202

  • MR. CHANDRASHEKHAR DNYANESHWAR JORI

    MR. CHANDRASHEKHAR DNYANESHWAR JORI

    Email: chandrashekhar.ph21223@inst.ac.in

    Reg. No.: PH21223

  • MS. KANIKA

    MS. KANIKA

    Email: kanika.ph20262@inst.ac.in

    Reg. No.: PH20262

  • MR. AJAY KUMAR

    MR. AJAY KUMAR

    Email: ajay.ph20208@inst.ac.in

    Reg. No.: PH20208

  • MR. ANEESH ALI

    MR. ANEESH ALI

    Email: aneesh.ph20205@inst.ac.in

    Reg. No.: PH20205

  • MR. AJAY KUMAR

    MR. AJAY KUMAR

    Email: ajaypharm.11@gmail.com

    Reg. No.:

Alumni

  • AJESH JOSHI

    AJESH JOSHI

    Reg. No.: IN-2024/06

    Designation: Intern Student

    Jan 2024 - Jul 2024

  • DR. RAHUL SAKLA

    DR. RAHUL SAKLA

    Reg. No.: RA-01-202145

    Designation: Post Docs/RA

    Jul 2022 - Jun 2023

  • MR. ANAS AHMAD

    MR. ANAS AHMAD

    Reg. No.: PH15210

    Designation: PhD Scholar

    Aug 2015 - Sep 2021

  • MR. AKSHAY RAGHU VYAWAHARE

    MR. AKSHAY RAGHU VYAWAHARE

    Reg. No.: PH18221

    Designation: PhD Scholar

    Aug 2018 - Jan 2024

  • MR. RAKESH MISHRA

    MR. RAKESH MISHRA

    Reg. No.: PH17232

    Designation: PhD Scholar

    Jan 2018 - Oct 2022

  • 1.

    Decoding Paradoxical Links of Cytokine Markers in Cognition: Cross talk between Physiology, Inflammaging, and Alzheimer’s Disease- Related Cognitive Decline , Hiba Khan, Talib Naseem, Pooja Kaushik, Jagriti Narang, Rehan Khan, Siddharth Panwar, Suhel Parvez , Ageing Research Reviews , 2024 , 101 , 102535 , 10.1016/j.arr.2024.102535

  • 2.

    2D MoS2 Plasmonic-Nanocavity based SERS Platform for Bilirubin Detection , Maharana. Akash, Himanshu Tyagi, Sushree Dash, Puspita Saha, Mamta Raturi, Jyoti Saini, Manpreet Kaur, Rehan Khan, Kiran. Hazra , Applied Physics Letters , 2024 , 125 , 143701

  • 3.

    Nanomedicine as potential cancer therapy via targeting dysregulated transcription factors , Anas Ahmad, Summya Rashid, Anis Ahmad Chaudhary, Abdullah S Alawam, Mohammad Ibrahim Alghonaim, Syed Shadab Raza, Rehan Khan , Seminars in Cancer Biology , 2023 , 89 , 38-60

  • 4.

    NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injury , Ravi Prakash, Akshay Vyawahare, Rahul Sakla, Neha Kumari, Ajay Kumar, Md Meraj Ansari, Kanika, Chandrashekhar Jori, Arshi Waseem, Abu Junaid Siddiqui, Mohsin Ali Khan, Avril AB Robertson, Rehan Khan, Syed Shadab Raza , ACS Nano , 2023 , 17 , 8680-8693 , 10.1021/acsnano.3c01760

  • 5.

    Nanoparticles mediated Localized therapy abrogates Autophagy through modulation of Beclin1 and Atg7 for the management of Ischemia-Reperfusion disorder , Ajay Kumar, Ravi Prakash, Anas Ahmad, Neha Kumari, Md. Meraj Ansari, Mohsin Ali Khan, Syed Shadab Raza, Rehan Khan , Chemical Engineering Journal , 2022 , 438 , 135557 , 10.1016/j.cej.2022.135557

  • 6.

    Caffeic acid modified nanomicelles inhibit articular cartilage deterioration and reduce disease severity in experimental inflammatory arthritis , Akshay Vyawahare, Ravi Prakash, Chandrashekhar Jori, Aneesh Ali, Syed Shadab Raza, Rehan Khan , ACS Nano , 2022 , 16 , 18579-18591 , 10.1021/acsnano.2c07027

  • 7.

    Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats : , Rehan Khan, Sarwat Sultana , Chemico-Biological Interactions , 2011 , 192 , 193-200 , 10.1016/j.cbi.2011.03.009

  • 8.

    Cellulose-Conjugated Copper-Oxide Nanoparticles for the Treatment of Ethanol-Induced Gastric Ulcers in Wistar Rats: , Kumar, A.; Selim, A.; Gowri, V.; Ahmad, A.; Vyawahare, A.; Nadim, A.; Siddiqui, Raza, S. S. , (2022) , ACS Biomaterials Science & Engineering , 10.1021/acsbiomaterials.2c00090

  • 9.

    Thiol-Functionalized Cellulose-Grafted Copper Oxide Nanoparticles for the Therapy of Experimental Colitis in Swiss Albino Mice: , Rakesh Kumar Mishra, Abdul Selim, Vijayendran Gowri, Anas Ahmad, Ahmed Nadeem, Nahid Siddiqui, Syed Shadab Raza , (2022) , 8: 2088-2095 , ACS Biomaterials Science & Engineering , 10.1021/acsbiomaterials.2c00124

  • 10.

    Nanotechnology-Assisted, Single-Chromophore-Based White-Light-Emitting Organic Materials with Bioimaging Properties: , Arif Hassan Dar, Vijayendran Gowri, Rakesh Kumar Mishra, Rehan Khan, Govindasamy Jayamurugan* , (2021) , 38: 430-438 , Langmuir , 10.1021/acs.langmuir.1c02797

  • 11.

    Enema Based Therapy Using Liposomal Formulation of Low Molecular Weight Heparin for Treatment of Active Ulcerative Colitis: New Adjunct Therapeutic Opportunity  : , Anas Ahmad# , Kalpesh Vaghasiya#, Ajay Kumar , Pravej Alam, Syed Shadab Raza, Rahul Kumar Verma*, Rehan Khan* , (2021) , 121: 111851 (Impact factor-7.32) , Materials Science and Engineering: C , https://doi.org/10.1016/j.msec.2020.111851

  • 12.

    Enteric-Coated Gelatin Nanoparticles Mediated Oral Delivery of 5-Aminosalicylic Acid Alleviates Severity of DSS-Induced Ulcerative Colitis: , Anas Ahmad, Md. Meraj Ansari, Rakesh Kumar Mishra, Ajay Kumar, Akshay Vyawahare, Rahul Kumar Verma, Syed Shadab Raza, Rehan Khan* , (2020) , 119: 111582 (Impact factor-7.32) , Materials Science and Engineering: C , 10.1016/j.msec.2020.111582

  • 13.

    Understanding the Monoclonal Antibody Involvement in Targeting the Activation of Tumor Suppressor Genes: , Rakesh Kumar Mishra, Anas Ahmad, Akshay Vyawahare, Ajay Kumar, Rehan Khan* , (2020) , 20: 1810-1823 , Current Topics in Medicinal Chemistry , 10.2174/1568026620666200616133814

  • 14.

    Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review: , Muneeb U Rehman, Adil Farooq, Rayeesa Ali, Sana Bashir, Nazirah Bashir, Samia Majeed, Syed Taifa, Sheikh Bilal Ahmad, Azher Arafah, Aga Syed Sameer*, Rehan Khan, Wajhul Qamar, Saiema Rasool, Anas Ahmad. , (2020) , 21: 436-465. , Current Drug Metabolism , 10.2174/1389200221666200620204914

  • 15.

    Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis.: , Mishra RK, Ahmad A, Kumar A, Vyawahare A, Raza SS, Rehan Khan* , (2020) , 116: 111103 , Materials Science and Engineering: C , 10.1016/j.msec.2020.111103

  • 16.

    Membrane Trafficking and Subcellular Drug Targeting Pathways.: , A Kumar, A Ahmad, A Vyawahare, R Khan*. , (2020) , Frontiers in Pharmacology , 10.3389/fphar.2020.00629

  • 17.

    Sivelestat-loaded nanostructured lipid carriers modulate oxidative and inflammatory stress in human dental pulp and mesenchymal stem cells subjected to oxygen-glucose deprivation: , Prakash R,Mishra RK ,Ahmad A,Khan MA,Rehan Khan,Syed Shadab Raza , (2020) , NA: 111700 , Materials Science and Engineering: C , 10.1016/j.msec.2020.111700

  • 18.

    Comparative Acute Intravenous Toxicity Study of Triple Polymer Layered Magnetic Nanoparticles with Bare Magnetic Nanoparticles in Swiss Albino Mice: , Anas Ahmad, Md. Meraj Ansari, Ajay Kumar, Akshay Vyawahare, Rakesh Kumar Mishra, Govindasamy Jayamurugan, Syed Shadab Raza, Rehan Khan* , (2020) , 14: 1362-1380. , Nanotoxicology , 10.1080/17435390.2020.1829144

  • 19.

    Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases: , Khan, A.Q.; Akhtar, S.; Prabhu, K.S.; Zarif, L.; Khan, R.; Alam, M.; Buddenkotte, J.; Ahmad, A.; Steinhoff, M.; Uddin, S. , (2020) , 21: 9264 , International Journal of Molecular Sciences , 10.3390/ijms21239264

  • 20.

    Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms: , Arafah, A.; Rehman, M.U.; Mir, T.M.; Wali, A.F.; Ali, R.; Qamar, W.; Khan, R.; Ahmad, A.; Aga, S.S.; Alqahtani, S.; Almatroudi, N.M. , (2020) , Plants, 9: 1784 , 10.3390/plants9121784

  • 21.

    Aminocellulose-Grafted-Polycaprolactone Coated Gelatin Nanoparticles Alleviate Inflammation in Rheumatoid Arthritis: A Combinational Therapeutic Approach: , Md. Meraj Ansari, Anas Ahmad, Ajay Kumar, Pravej Alam, Tajdar Husain Khan, Govindasamy Jayamurugan, Syed Shadab Raza, Rehan Khan* , (2020) , NA: NA , Carbohydrate Polymers

  • 22.

    Zinc Gluconate-Loaded Chitosan Nanoparticles Reduce Severity of Collagen-Induced Arthritis in Wistar Rats: , Md. Meraj Ansari ,Anas Ahmad,Rakesh Kumar Mishra,Syed Shadab Raza,Rehan Khan , (2019) , ACS Biomater. Sci. Eng.

  • 23.

    Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting: , Anas Ahmad,Farheen Khan,Rakesh Kumar Mishra,Rehan Khan , (2019) , 62: 10475-10496 , J. Med. Chem.

  • 24.

    Hyperbranched polymer-functionalized magnetic nanoparticles mediated hyperthermia and niclosamide bimodal therapy of Colorectal Cancer Cells.: , A Ahmad, A Gupta, MM Ansari, A Vyawahare, G Jayamurugan*, R. Khan* , (2019) , 6: 1102-1111 , ACS Biomater. Sci. Eng. , 10.1021/acsbiomaterials.9b01947

  • 25.

    Neuroprotective Strategies for Neurological Disorders by Natural Products: An update: , Muneeb U Rehman,F Adil Wali,Anas Ahmad,Sheeba Shakeel,Saiema Rasool,Rayeesa Ali,Shazada Mudasir Rashid,Hasan Madkhali Ganaie,Majid Ahmad,Rehan Khan , (2019) , 17: 247-267 , Current Neuropharmacology

  • 26.

    Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects: , Anas Ahmad,Rakesh Kumar Mishra,Akshay Vyawahare,Ajay Kumar,Muneeb U. Rehman,Wajhul Qamar,Abdul Quaiyoom Khan,Rehan Khan , (2019) , 27: 1113-1126 , Saudi Pharmaceutical Journal

  • 27.

    Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers: , Rehman MU, Khan AQ, Tahir M, Sultana S. , (2018) , Environmental Toxicology

  • 28.

    Aptamer based nanobiosensors: Promising healthcare devices: , Aamir Hanif ,Rabia Farooq,Muneeb U. Rehman,Rehan Khan,Sabhiya majid,Majid Ahmed Ganaie , (2018) , 27: 312–319 , Saudi Pharmaceutical Journal

  • 29.

    Gelatin-Coated Polycaprolactone Nanoparticle-Mediated Naringenin Delivery Rescue Human Mesenchymal Stem Cells from Oxygen Glucose Deprivation-Induced Inflammatory Stress: , Anas Ahmad,Eram Fauzia, Manish Kumar,Rakesh Kumar Mishra,Ajay Kumar,Mohsin Ali Khan,Syed Sadab Raza,Rehan Khan , (2018) , 2: 683-695 , ACS Biomater. Sci. Eng.

  • 30.

    Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells: , A. Gupta, A. AHMAD, H. Singh, S. Kaur, Neethu K M, M. M. Ansari, G. Jayamurugan*, R. Khan* , (2018) , 19: 803-815 , Biomacromolecules , 10.1021/acs.biomac.7b01607

  • 31.

    Synthetic lethality: From Research to Personalized Cancer Nanomedicine.: , Gupta A, Ahmad A, Dar AI , (2018)

  • 32.

    Trichloroethylene mediated cytotoxicity in Human Epidermal Keratinocytes is mediated by the rapid accumulation of intracellular calcium: Interception by Naringenin.: , Ali F, Khan AQ,Sultana S , (2016) , 35(2): 147-61. , Human and Experimental Toxicology , 10.1177/0960327115578865

  • 33.

    18-β Glycyrrhetinic acid alleviates 2-Acetylaminofluorene induced hepatotoxicity in wistar rats: , Hasan SK, Ali N, Khan AQ, Rehman MU, Tahir M, Lateef A, Nafees S, Mehdi SJ, Rashid S, Shahid A, Sultana S , (2015) , 34(6): 628-41 , Human and Experimental Toxicology , 10.1177/0960327114554045

  • 34.

    Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice.: , Majed F, Rashid S, Khan AQ, Nafees S, Ali N, Ali R,Hasan SK, Mehdi SJ, Sultana S. , (2015) , 399(1-2): 217-28 , Molecular and Cellular Biochemistry , 10.1007/s11010-014-2248-3

  • 35.

    D-limonene suppresses Doxorubicin induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats: , Rehman MU, Tahir M, Khan AQ, Oday-O-Hamiza, Lateef A, Hassan SK, Rashid S, Ali N, Zeeshan M, Sultana S , (2014) , 239(4): 465-76. , Experimental Biology and Medicine (Maywood) , 10.1177/1535370213520112

  • 36.

    Chemopreventive effects of Aloin against DMH-induced preneoplastic lesions in the colonof Wistar rats: , Hamiza OO, Rehman MU, Tahir M, Khan AQ, Lateef A, Sultana S. , (2014) , 33(2): 148-63 , Human and Experimental Toxicology , 10.1177/0960327113493307

  • 37.

    Alleviation of hepatic injury by chrysin in cisplatin administered rats: Probable role of inflammatory markers: , Rehman MU, Tahir M, Quaiyoom A, Lateef A, Oday-O-Hamiza, Hassan SK, Ali N, Qamar W, Sultana S. , (2014) , 66(6): 1050-9 , Pharmacol Reports , 10.1016/j.pharep.2014.06.004

  • 38.

    Methanolic extract of Terminalia chebula protects against DMH-induced colon damage in Wistar Rats by restoring antioxidant enzyme activities and suppressing inflammation: , Hamiza OO,Rehman MU, Tahir M, Lateef A, Khan AQ, Qamar W, Sultana S. , (2014) , 6: 0975-9344. , International Journal of Drug Development & Research

  • 39.

    Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: Possible role of oxidative stress and inflammati: , Khan AQ, Tahir M, Lateef A, Rehman MU, Ali F, Hamiza OO, Hasan SK, Sultana S. , (2014) , 66(2): 249-58 , Nutrition and Cancer , 10.1080/01635581.2014.863365

  • 40.

    Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-κB.: , Khan AQ, Qamar W, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Hasan SK, Sultana S. , (2013) , 94(3): 419-429 , Experimental and Molecular Pathology , 10.1016/j.yexmp.2013.01.006

  • 41.

    Farnesol protects against intratracheally instilled cigarette smoke extract-induced histological alterations and oxidative stress in prostate of Wistar rats: , Lateef A, Rehman MU, Tahir M, Khan AQ, Qamar W, Sultana S. , (2013) , 20(1): 35-42 , Toxicology International

  • 42.

    Glycyrrhizic acid suppresses the development of precancerous lesions via regulating thehyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats.: , Khan AQ, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Sultana S. , (2013) , 8(2): , PLoS One , 10.1371/journal.pone.0056020

  • 43.

    Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model.: , Tahir M, Rehman MU, Lateef A, Khan AQ, Qamar W, Hamiza OO, Ali F, Hasan SK, Sultana S. , (2013) , 220(3): 205-18 , Toxicology Letters , 10.1016/j.toxlet.2013.04.004

  • 44.

    Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile and oxidative stress: amelioration by daidzein.: , Lateef A, Khan AQ, Tahir M, Rehman MU, Ali F,Hamiza OO, Sultana S. , (2013) , 374(1-2): 49-59 , Molecular and Cellular Biochemistry , 10.1007/s11010-012-1504-7

  • 45.

    Assessment of augmented immune surveillance and tumor cell death by cytoplasmic stabilization of p53 as a chemopreventive strategy of three promising medicinal herbs in murine two stage skin: , Ali F, Khan AQ, Lateef A, Tahir M, Sultana S. , (2013) , 13(4): 351-367 , Integrative Cancer Therapies , 10.1177/1534735413513831

  • 46.

    Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB.: , Rehman MU, Tahir M, Khan AQ, Lateef A, Oday-O-Hamiza, Qamar W, Ali F, Sultana S , (2013) , 216(2-3): 146-58 , Toxicology Letters , 10.1016/j.toxlet.2012.11.013

  • 47.

    Diosmin protects against TCE (trichloroethylene) induced renal injury in Wistar rats: Plausible role of p53, Bax and caspases.: , Rehman MU, Tahir M, Khan AQ, Lateef A, Oday-O-Hamiza, Ali F, Sultana S. , (2013) , 1-12 , British Journal of Nutrition , 10.1017/S0007114512005752

  • 48.

    Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation.: , Tahir M, Rehman MU, Lateef A, Khan AQ, Ali F, Oday-O-Hamiza, Sultana S. , (2013) , 47(2): 131-9 , Alcohol , 10.1016/j.alcohol.2012.12.010

  • 49.

    Chrysin protects against cisplatin-induced colon toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53.: , Khan AQ, Qamar W, Lateef A, Tahir M, Rehman MU Ali F, Sultana S. , (2012) , 258(3): 315-29 , Toxicology and Applied Pharmacology , 10.1016/j.taap.2011.11.013

  • 50.

    Chemopreventive effect of Quercus infectoria against chemically induced renal toxicity and carcinogenesis : , Rehman MU, Tahir M, Ali F, Qamar W, Khan AQ, Lateef A, Hamiza OO, Sultana S. , (2012) , 4 (2): 336-351 , International Journal of Drug Development & Research

  • 51.

    Methanolic extract of Bacop amonnieri protects against KBrO3-induced renal damage in Wistar rats by restoring antioxidant enzyme activities and suppressing inflammation and apoptosis : , Rehman MU, Tahir M, Khan AQ,Lateef A, Hamiza OO, Kazim S, Ali F, Sultana S. , (2012) , 5(11): 5231-5238. , Journal of Pharmacy Research , 10.1007/s11010-012-1504-7

  • 52.

    Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase.: , Qamar W, Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S. , (2012) , 291(1-3): 25-31 , Toxicology , 10.1016/j.tox.2011.10.012

  • 53.

    Amelioration of 1,2 Dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats : , Hamiza OO, Rehman MU, Tahir M, Khan AQ, Lateef A, Ali F, Sultana S , (2012) , 13(9): 4393-402 , Asian Pac J Cancer Prev. , 10.7314/apjcp.2012.13.9.4393

  • 54.

    Benzo(a)pyrene-Induced Pulmonary Inflammation, Edema, Surfactant Dysfunction, and Injuries in rats: Alleviation by Farnesol.: , Qamar W, Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S. , (2012) , 38(1): 19-27 , Experimental Lung Research. , 10.3109/01902148.2011.632064

  • 55.

    Chrysin abrogates cisplatin-induced oxidative stress, p53 expression, goblet cell disintegration and apoptotic responses in the jejunum of Wistar rats.: , Abdul Quaiyoom Khan, Wajhul Qamar, Abdul Lateef, Farrah Ali, Muneeb U. Rehman, Mir Tahir, Swati Sharma and Sarwat Sultana. , (2012) , British Journal of Nutrition , 108(9): 1574-85. , 10.1017/S0007114511007239

  • 56.

    Soy isoflavones (daidzein&genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-κB in Swiss albino mice.: , Khan AQ, Rehman MU, Lateef A, Tahir M, Ali F, Sultana S. , (2012) , 302(2-3): 266-74 , Toxicology , 10.1016/j.tox.2012.08.008

  • 57.

    Nephroprotective efficacy of chrysin against cisplatin induced toxicity via attenuation of oxidative stress.: , Sultana S, Verma K , (2012) , 64(6): 872-81. , Journal of Pharmacy and Pharmacology , 10.1111/j.2042-7158.2012.01470.x

  • 58.

    Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid.: , Rehman MU, Tahir M, Ali F, Qamar W, Lateef A, Quaiyoom A, Oday-O-Hamiza, Sultana S. , (2012) , 365(1-2): 119-27 , Molecular and Cellular Biochemistry , 10.1007/s11010-012-1250-x

  • 1.

    Effect of Pesticides on Fish Fauna: Threats, Challenges, and Possible Remedies: , Shafat Ali,Adil Farooq Wali,Ali Mohd Yatoo,Sabhiya Majid,Saiema Rasool,Rehan Khan,Md Niamat Ali,Javaid Ahmad Wani,Sanah Farooq,Shabhat Rasool,Hilal Ahmad Wani,Muneeb U. Rehman , (2020) , 27-54 , Bioremediation and Biotechnology

  • 2.

    A Mechanistic Perspective on Chemopreventive and Therapeutic potential of Phytochemicals in Honey : , A Ali, J Yangchan, A Ahmad, A Kumar, RK Mishra, A Vyawahare, A Rukhsana, GM Ashraf, S Shakil, Rehan Khan* , (2020) , Accepted: NA , Therapeutic Applications of Honey and its Phytochemical , NA

  • 3.

    Naringenin (4, 5, 7-trihydroxyflavanone) as Potent Neuro-protective Agent: From Chemistry to Medicine.: , Amin I, Majid S, Farooq A, Isaq S, Wani HA, Farida Noor, Rehan Khan, Shakeel S, Bhat SA, Ahmad A, Madkhali H, Ahmad M, Rehman MU , (2020) , 65: NA , Studies in Natural Products Chemistry , https://doi.org/10.1016/B978-0-12-817905-5.00008-1

  • 4.

    Nano-sized delivery systems for plant-derived therapeutic compounds and their synthetic derivative for cancer therapy: , Rehman MU. Amin H, Khan A, Makeen H, Rashid H, Amin Insha, Hussain M, Rehan Khan, Azher Arafah , (2020) , Phytomedicine: A Treasure of Pharmacologically Active Products from Plants

  • 5.

    An overview of the pharmacological properties and potential applications of lavander and cumin : , Rehman MU,Ahmad SA ,Shah A,Kashani B,Ahmad A,Mishra R,Rehan Khan,Rashid SM,Ali R,Rasool S , (2019) , Apple Academic Press

  • 6.

    Chemical Composition and Biological Uses of Artemisia absinthium (Wormwood): , Rahil Razzak Bhat,Muneeb U. Rehman,Ambreen Shabir,Manzoor U. Rahman Mir,Anas Ahmad,Rehan Khan,Mubashir Husaain Masoodi,Hassan Madkhali,Majid Ahmad Ganaie , (2019) , 3: 37-63 , Springer

  • 7.

    Role of 3D tissue engineering models for human cancer and drug development: , Khan AQ,Rashid K,Raza SS,Rehan Khan,Mraiche F,Shahab Uddin , (2019) , 309-322 , Animal Models in Cancer Drug Discovery

  • 1.

    Applying synthetic lethality to nanomedicine: LCS-1 loaded magnetite and polymeric nanoparticles for the treatment of BLM and CHEK2-deficient colorectal cancer cells: In CANCER MEDICINE 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY , A. Gupta, Ahmad A , (2018) , 7: 27-28

  • Travel Grant awarded by Department of Science and Technology, Ministry of Higher Education, New Delhi, India, for attending international conference “The Tumor Microenvironment” held in Dublin, Ireland in September 2012.

    Award from Jamia Hamdard (Hamdard University) for publishing research work in high impact (more than 3.0) journals “PLoS One”, “British Journal of Nutrition” and “Toxicology and Applied Pharmacology”.

    Member of Royal Microscopical Society

  • Research Fellowship for Science and Meritorious Student (RFSMS):niversity Grants Commission (UGC),, New Delhi, India. (April 2009 to April 2011 )

  • Senior Research Fellowship (SRF):Indian Council of Medical Research (ICMR),, New Delhi, India. (June 2011 to October 2013 )

  • Post-doctoral Fellow:Manitoba Institute of Cell Biology, Cancercare Manitoba, University of Manitoba, Winnipeg,, MB, CANADA. (October 2013 to June 2014 )

  • Scientist-B:Institute of Nano Science and Technology, Phase-10, Mohali (February 2015 to December 2018 )

  • Scientist-C:Institute of Nano Science and Technology, Phase-10, Mohali (January 2019 to December 2021 )

  • Scientist-D:Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali, Punjab (January 2022 to Present till date )

  • Title: Self-titrating inflammation-responsive injectable smart nano-formulations for repetitive delivery of DMARDs and corticosteroids against Rheumatoid Arthritis

    PI: Dr. Rahul K. Verma

    CO-PI: Dr. Rehan Khan

    Funding Amount: 41 lakhs

    Tenure: 3 years

    Funding Agency: DST-SERB(CRG )

  • Title: Enzyme-Responsive hydrogel for site-specific drug delivery as potential therapy for Colitis

    PI: Dr. Rehan Khan

    CO-PI: Dr. Rahul K. Verma

    Funding Amount: 43,22,120

    Tenure: 3 years

    Funding Agency: DST-SERB- Core Research Grant

  • Title: Nanoparticle-mediated inhibition of PRDX2 for selective killing of CHEK2-defective colorectal cancer cells by synthetic lethality

    PI: Dr. Rehan Khan

    Funding Amount: 22,16,000

    Tenure: 3 years

    Funding Agency: DST-SERB- Young Scientist