Scientist-D
Synthetic Lethality and Cancer - Targeted Therapy by Small Molecule Inhibitors/Nano-Formulations. Development of inflammation-targeting carriers for the therapy of Arthritis and Ulcerative Colitis.
E-mail:
rehankhan@inst.ac.inGoogle Link:
Google LinkColorectal cancer is one of the greatest causes of cancer related mortalities on the global scale. In the context of cancer chemotherapy, synthetic lethality is a recent paradigm where interaction of two genes is explored, such that simultaneous inhibition or silencing of both the genes becomes lethal for the cancer cells while bearing least impact on the healthy cells. Our research deals with the formulation and characterization of novel nanoparticles for drug delivery purposes for synthetic lethal therapy mediated targeting of colorectal cancer. Most of the anti-cancer compounds have various limitations like solubility issues, poor bioavailability and off target effects which restrict their employability in the clinical platforms. To surpass these limitations, we develop customized nanoparticles for enhanced therapeutic efficacy and selective or targeted therapy of cancer. Our lab is focused on to develop inflammation-targeting carriers using biocompatible materials for the therapy of RA and UC.
Colorectal cancer is one of the greatest causes of cancer related mortalities on the global scale. In the context of cancer chemotherapy, synthetic lethality is a recent paradigm where interaction of two genes is explored, such that simultaneous inhibition or silencing of both the genes becomes lethal for the cancer cells while bearing least impact on the healthy cells. Our research deals with the formulation and characterization of novel nanoparticles for drug delivery purposes for synthetic lethal therapy mediated targeting of colorectal cancer. Most of the anti-cancer compounds have various limitations like solubility issues, poor bioavailability and off target effects which restrict their employability in the clinical platforms. To surpass these limitations, we develop customized nanoparticles for enhanced therapeutic efficacy and selective or targeted therapy of cancer.
Email: ajesh.ph24207@inst.ac.in
Reg. No.: PH24207
Email: ashraf.oh23239@inst.ac.in
Reg. No.: PH23239
Email: bhuvnesh.ph23202@inst.ac.in
Reg. No.: PH23202
Email: jatin.ph22237@inst.ac.in
Reg. No.: PH22237
Email: shubham.ph22202@inst.ac.in
Reg. No.: PH22202
Email: chandrashekhar.ph21223@inst.ac.in
Reg. No.: PH21223
Email: kanika.ph20262@inst.ac.in
Reg. No.: PH20262
Email: ajay.ph20208@inst.ac.in
Reg. No.: PH20208
Email: aneesh.ph20205@inst.ac.in
Reg. No.: PH20205
Email: ajaypharm.11@gmail.com
Reg. No.:
Reg. No.: IN-2024/06
Designation: Intern Student
Jan 2024 - Jul 2024
Reg. No.: RA-01-202145
Designation: Post Docs/RA
Jul 2022 - Jun 2023
Reg. No.: PH15210
Designation: PhD Scholar
Aug 2015 - Sep 2021
Reg. No.: PH18221
Designation: PhD Scholar
Aug 2018 - Jan 2024
Reg. No.: PH17232
Designation: PhD Scholar
Jan 2018 - Oct 2022
1.
Cellulose-Conjugated Copper-Oxide Nanoparticles for the Treatment of Ethanol-Induced Gastric Ulcers in Wistar Rats: , Kumar, A.; Selim, A.; Gowri, V.; Ahmad, A.; Vyawahare, A.; Nadim, A.; Siddiqui, Raza, S. S. , (2022) , ACS Biomaterials Science & Engineering , 10.1021/acsbiomaterials.2c000902.
Thiol-Functionalized Cellulose-Grafted Copper Oxide Nanoparticles for the Therapy of Experimental Colitis in Swiss Albino Mice: , Rakesh Kumar Mishra, Abdul Selim, Vijayendran Gowri, Anas Ahmad, Ahmed Nadeem, Nahid Siddiqui, Syed Shadab Raza , (2022) , 8: 2088-2095 , ACS Biomaterials Science & Engineering , 10.1021/acsbiomaterials.2c001243.
Nanotechnology-Assisted, Single-Chromophore-Based White-Light-Emitting Organic Materials with Bioimaging Properties: , Arif Hassan Dar, Vijayendran Gowri, Rakesh Kumar Mishra, Rehan Khan, Govindasamy Jayamurugan* , (2021) , 38: 430-438 , Langmuir , 10.1021/acs.langmuir.1c027974.
Enema Based Therapy Using Liposomal Formulation of Low Molecular Weight Heparin for Treatment of Active Ulcerative Colitis: New Adjunct Therapeutic Opportunity : , Anas Ahmad# , Kalpesh Vaghasiya#, Ajay Kumar , Pravej Alam, Syed Shadab Raza, Rahul Kumar Verma*, Rehan Khan* , (2021) , 121: 111851 (Impact factor-7.32) , Materials Science and Engineering: C , https://doi.org/10.1016/j.msec.2020.1118515.
Enteric-Coated Gelatin Nanoparticles Mediated Oral Delivery of 5-Aminosalicylic Acid Alleviates Severity of DSS-Induced Ulcerative Colitis: , Anas Ahmad, Md. Meraj Ansari, Rakesh Kumar Mishra, Ajay Kumar, Akshay Vyawahare, Rahul Kumar Verma, Syed Shadab Raza, Rehan Khan* , (2020) , 119: 111582 (Impact factor-7.32) , Materials Science and Engineering: C , 10.1016/j.msec.2020.1115826.
Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review: , Muneeb U Rehman, Adil Farooq, Rayeesa Ali, Sana Bashir, Nazirah Bashir, Samia Majeed, Syed Taifa, Sheikh Bilal Ahmad, Azher Arafah, Aga Syed Sameer*, Rehan Khan, Wajhul Qamar, Saiema Rasool, Anas Ahmad. , (2020) , 21: 436-465. , Current Drug Metabolism , 10.2174/13892002216662006202049147.
Membrane Trafficking and Subcellular Drug Targeting Pathways.: , A Kumar, A Ahmad, A Vyawahare, R Khan*. , (2020) , Frontiers in Pharmacology , 10.3389/fphar.2020.006298.
Understanding the Monoclonal Antibody Involvement in Targeting the Activation of Tumor Suppressor Genes: , Rakesh Kumar Mishra, Anas Ahmad, Akshay Vyawahare, Ajay Kumar, Rehan Khan* , (2020) , 20: 1810-1823 , Current Topics in Medicinal Chemistry , 10.2174/15680266206662006161338149.
Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis.: , Mishra RK, Ahmad A, Kumar A, Vyawahare A, Raza SS, Rehan Khan* , (2020) , 116: 111103 , Materials Science and Engineering: C , 10.1016/j.msec.2020.11110310.
Comparative Acute Intravenous Toxicity Study of Triple Polymer Layered Magnetic Nanoparticles with Bare Magnetic Nanoparticles in Swiss Albino Mice: , Anas Ahmad, Md. Meraj Ansari, Ajay Kumar, Akshay Vyawahare, Rakesh Kumar Mishra, Govindasamy Jayamurugan, Syed Shadab Raza, Rehan Khan* , (2020) , 14: 1362-1380. , Nanotoxicology , 10.1080/17435390.2020.182914411.
Sivelestat-loaded nanostructured lipid carriers modulate oxidative and inflammatory stress in human dental pulp and mesenchymal stem cells subjected to oxygen-glucose deprivation: , Prakash R,Mishra RK ,Ahmad A,Khan MA,Rehan Khan,Syed Shadab Raza , (2020) , NA: 111700 , Materials Science and Engineering: C , 10.1016/j.msec.2020.11170012.
Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases: , Khan, A.Q.; Akhtar, S.; Prabhu, K.S.; Zarif, L.; Khan, R.; Alam, M.; Buddenkotte, J.; Ahmad, A.; Steinhoff, M.; Uddin, S. , (2020) , 21: 9264 , International Journal of Molecular Sciences , 10.3390/ijms2123926413.
Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms: , Arafah, A.; Rehman, M.U.; Mir, T.M.; Wali, A.F.; Ali, R.; Qamar, W.; Khan, R.; Ahmad, A.; Aga, S.S.; Alqahtani, S.; Almatroudi, N.M. , (2020) , Plants, 9: 1784 , 10.3390/plants912178414.
Aminocellulose-Grafted-Polycaprolactone Coated Gelatin Nanoparticles Alleviate Inflammation in Rheumatoid Arthritis: A Combinational Therapeutic Approach: , Md. Meraj Ansari, Anas Ahmad, Ajay Kumar, Pravej Alam, Tajdar Husain Khan, Govindasamy Jayamurugan, Syed Shadab Raza, Rehan Khan* , (2020) , NA: NA , Carbohydrate Polymers15.
Zinc Gluconate-Loaded Chitosan Nanoparticles Reduce Severity of Collagen-Induced Arthritis in Wistar Rats: , Md. Meraj Ansari ,Anas Ahmad,Rakesh Kumar Mishra,Syed Shadab Raza,Rehan Khan , (2019) , ACS Biomater. Sci. Eng.16.
Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting: , Anas Ahmad,Farheen Khan,Rakesh Kumar Mishra,Rehan Khan , (2019) , 62: 10475-10496 , J. Med. Chem.17.
Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects: , Anas Ahmad,Rakesh Kumar Mishra,Akshay Vyawahare,Ajay Kumar,Muneeb U. Rehman,Wajhul Qamar,Abdul Quaiyoom Khan,Rehan Khan , (2019) , 27: 1113-1126 , Saudi Pharmaceutical Journal18.
Neuroprotective Strategies for Neurological Disorders by Natural Products: An update: , Muneeb U Rehman,F Adil Wali,Anas Ahmad,Sheeba Shakeel,Saiema Rasool,Rayeesa Ali,Shazada Mudasir Rashid,Hasan Madkhali Ganaie,Majid Ahmad,Rehan Khan , (2019) , 17: 247-267 , Current Neuropharmacology19.
Hyperbranched polymer-functionalized magnetic nanoparticles mediated hyperthermia and niclosamide bimodal therapy of Colorectal Cancer Cells.: , A Ahmad, A Gupta, MM Ansari, A Vyawahare, G Jayamurugan*, R. Khan* , (2019) , 6: 1102-1111 , ACS Biomater. Sci. Eng. , 10.1021/acsbiomaterials.9b0194720.
Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells: , A. Gupta, A. AHMAD, H. Singh, S. Kaur, Neethu K M, M. M. Ansari, G. Jayamurugan*, R. Khan* , (2018) , 19: 803-815 , Biomacromolecules , 10.1021/acs.biomac.7b0160721.
Gelatin-Coated Polycaprolactone Nanoparticle-Mediated Naringenin Delivery Rescue Human Mesenchymal Stem Cells from Oxygen Glucose Deprivation-Induced Inflammatory Stress: , Anas Ahmad,Eram Fauzia, Manish Kumar,Rakesh Kumar Mishra,Ajay Kumar,Mohsin Ali Khan,Syed Sadab Raza,Rehan Khan , (2018) , 2: 683-695 , ACS Biomater. Sci. Eng.22.
Aptamer based nanobiosensors: Promising healthcare devices: , Aamir Hanif ,Rabia Farooq,Muneeb U. Rehman,Rehan Khan,Sabhiya majid,Majid Ahmed Ganaie , (2018) , 27: 312–319 , Saudi Pharmaceutical Journal23.
Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers: , Rehman MU, Khan AQ, Tahir M, Sultana S. , (2018) , Environmental Toxicology24.
Synthetic lethality: From Research to Personalized Cancer Nanomedicine.: , Gupta A, Ahmad A, Dar AI , (2018)25.
Trichloroethylene mediated cytotoxicity in Human Epidermal Keratinocytes is mediated by the rapid accumulation of intracellular calcium: Interception by Naringenin.: , Ali F, Khan AQ,Sultana S , (2016) , 35(2): 147-61. , Human and Experimental Toxicology , 10.1177/096032711557886526.
18-β Glycyrrhetinic acid alleviates 2-Acetylaminofluorene induced hepatotoxicity in wistar rats: , Hasan SK, Ali N, Khan AQ, Rehman MU, Tahir M, Lateef A, Nafees S, Mehdi SJ, Rashid S, Shahid A, Sultana S , (2015) , 34(6): 628-41 , Human and Experimental Toxicology , 10.1177/096032711455404527.
Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice.: , Majed F, Rashid S, Khan AQ, Nafees S, Ali N, Ali R,Hasan SK, Mehdi SJ, Sultana S. , (2015) , 399(1-2): 217-28 , Molecular and Cellular Biochemistry , 10.1007/s11010-014-2248-328.
Chemopreventive effects of Aloin against DMH-induced preneoplastic lesions in the colonof Wistar rats: , Hamiza OO, Rehman MU, Tahir M, Khan AQ, Lateef A, Sultana S. , (2014) , 33(2): 148-63 , Human and Experimental Toxicology , 10.1177/096032711349330729.
Alleviation of hepatic injury by chrysin in cisplatin administered rats: Probable role of inflammatory markers: , Rehman MU, Tahir M, Quaiyoom A, Lateef A, Oday-O-Hamiza, Hassan SK, Ali N, Qamar W, Sultana S. , (2014) , 66(6): 1050-9 , Pharmacol Reports , 10.1016/j.pharep.2014.06.00430.
Methanolic extract of Terminalia chebula protects against DMH-induced colon damage in Wistar Rats by restoring antioxidant enzyme activities and suppressing inflammation: , Hamiza OO,Rehman MU, Tahir M, Lateef A, Khan AQ, Qamar W, Sultana S. , (2014) , 6: 0975-9344. , International Journal of Drug Development & Research31.
Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: Possible role of oxidative stress and inflammati: , Khan AQ, Tahir M, Lateef A, Rehman MU, Ali F, Hamiza OO, Hasan SK, Sultana S. , (2014) , 66(2): 249-58 , Nutrition and Cancer , 10.1080/01635581.2014.86336532.
D-limonene suppresses Doxorubicin induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats: , Rehman MU, Tahir M, Khan AQ, Oday-O-Hamiza, Lateef A, Hassan SK, Rashid S, Ali N, Zeeshan M, Sultana S , (2014) , 239(4): 465-76. , Experimental Biology and Medicine (Maywood) , 10.1177/153537021352011233.
Glycyrrhizic acid suppresses the development of precancerous lesions via regulating thehyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats.: , Khan AQ, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Sultana S. , (2013) , 8(2): , PLoS One , 10.1371/journal.pone.005602034.
Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile and oxidative stress: amelioration by daidzein.: , Lateef A, Khan AQ, Tahir M, Rehman MU, Ali F,Hamiza OO, Sultana S. , (2013) , 374(1-2): 49-59 , Molecular and Cellular Biochemistry , 10.1007/s11010-012-1504-735.
Farnesol protects against intratracheally instilled cigarette smoke extract-induced histological alterations and oxidative stress in prostate of Wistar rats: , Lateef A, Rehman MU, Tahir M, Khan AQ, Qamar W, Sultana S. , (2013) , 20(1): 35-42 , Toxicology International36.
Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model.: , Tahir M, Rehman MU, Lateef A, Khan AQ, Qamar W, Hamiza OO, Ali F, Hasan SK, Sultana S. , (2013) , 220(3): 205-18 , Toxicology Letters , 10.1016/j.toxlet.2013.04.00437.
Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: possible role of p38 MAP Kinase and NF-κB.: , Khan AQ, Qamar W, Lateef A, Rehman MU, Tahir M, Ali F, Hamiza OO, Hasan SK, Sultana S. , (2013) , 94(3): 419-429 , Experimental and Molecular Pathology , 10.1016/j.yexmp.2013.01.00638.
Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB.: , Rehman MU, Tahir M, Khan AQ, Lateef A, Oday-O-Hamiza, Qamar W, Ali F, Sultana S , (2013) , 216(2-3): 146-58 , Toxicology Letters , 10.1016/j.toxlet.2012.11.01339.
Diosmin protects against TCE (trichloroethylene) induced renal injury in Wistar rats: Plausible role of p53, Bax and caspases.: , Rehman MU, Tahir M, Khan AQ, Lateef A, Oday-O-Hamiza, Ali F, Sultana S. , (2013) , 1-12 , British Journal of Nutrition , 10.1017/S000711451200575240.
Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation.: , Tahir M, Rehman MU, Lateef A, Khan AQ, Ali F, Oday-O-Hamiza, Sultana S. , (2013) , 47(2): 131-9 , Alcohol , 10.1016/j.alcohol.2012.12.0101.
Effect of Pesticides on Fish Fauna: Threats, Challenges, and Possible Remedies: , Shafat Ali,Adil Farooq Wali,Ali Mohd Yatoo,Sabhiya Majid,Saiema Rasool,Rehan Khan,Md Niamat Ali,Javaid Ahmad Wani,Sanah Farooq,Shabhat Rasool,Hilal Ahmad Wani,Muneeb U. Rehman , (2020) , 27-54 , Bioremediation and Biotechnology2.
A Mechanistic Perspective on Chemopreventive and Therapeutic potential of Phytochemicals in Honey : , A Ali, J Yangchan, A Ahmad, A Kumar, RK Mishra, A Vyawahare, A Rukhsana, GM Ashraf, S Shakil, Rehan Khan* , (2020) , Accepted: NA , Therapeutic Applications of Honey and its Phytochemical , NA3.
Naringenin (4, 5, 7-trihydroxyflavanone) as Potent Neuro-protective Agent: From Chemistry to Medicine.: , Amin I, Majid S, Farooq A, Isaq S, Wani HA, Farida Noor, Rehan Khan, Shakeel S, Bhat SA, Ahmad A, Madkhali H, Ahmad M, Rehman MU , (2020) , 65: NA , Studies in Natural Products Chemistry , https://doi.org/10.1016/B978-0-12-817905-5.00008-14.
Nano-sized delivery systems for plant-derived therapeutic compounds and their synthetic derivative for cancer therapy: , Rehman MU. Amin H, Khan A, Makeen H, Rashid H, Amin Insha, Hussain M, Rehan Khan, Azher Arafah , (2020) , Phytomedicine: A Treasure of Pharmacologically Active Products from Plants5.
An overview of the pharmacological properties and potential applications of lavander and cumin : , Rehman MU,Ahmad SA ,Shah A,Kashani B,Ahmad A,Mishra R,Rehan Khan,Rashid SM,Ali R,Rasool S , (2019) , Apple Academic Press6.
Chemical Composition and Biological Uses of Artemisia absinthium (Wormwood): , Rahil Razzak Bhat,Muneeb U. Rehman,Ambreen Shabir,Manzoor U. Rahman Mir,Anas Ahmad,Rehan Khan,Mubashir Husaain Masoodi,Hassan Madkhali,Majid Ahmad Ganaie , (2019) , 3: 37-63 , Springer7.
Role of 3D tissue engineering models for human cancer and drug development: , Khan AQ,Rashid K,Raza SS,Rehan Khan,Mraiche F,Shahab Uddin , (2019) , 309-322 , Animal Models in Cancer Drug Discovery1.
Applying synthetic lethality to nanomedicine: LCS-1 loaded magnetite and polymeric nanoparticles for the treatment of BLM and CHEK2-deficient colorectal cancer cells: In CANCER MEDICINE 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY , A. Gupta, Ahmad A , (2018) , 7: 27-28Travel Grant awarded by Department of Science and Technology, Ministry of Higher Education, New Delhi, India, for attending international conference “The Tumor Microenvironment” held in Dublin, Ireland in September 2012.
Award from Jamia Hamdard (Hamdard University) for publishing research work in high impact (more than 3.0) journals “PLoS One”, “British Journal of Nutrition” and “Toxicology and Applied Pharmacology”.
Member of Royal Microscopical Society
Research Fellowship for Science and Meritorious Student (RFSMS):niversity Grants Commission (UGC),, New Delhi, India. (April 2009 to April 2011 )
Senior Research Fellowship (SRF):Indian Council of Medical Research (ICMR),, New Delhi, India. (June 2011 to October 2013 )
Post-doctoral Fellow:Manitoba Institute of Cell Biology, Cancercare Manitoba, University of Manitoba, Winnipeg,, MB, CANADA. (October 2013 to June 2014 )
Scientist-B:Institute of Nano Science and Technology, Phase-10, Mohali (February 2015 to December 2018 )
Scientist-C:Institute of Nano Science and Technology, Phase-10, Mohali (January 2019 to December 2021 )
Scientist-D:Institute of Nano Science and Technology, Knowledge City, Sector-81, Mohali, Punjab (January 2022 to Present till date )
Title: Self-titrating inflammation-responsive injectable smart nano-formulations for repetitive delivery of DMARDs and corticosteroids against Rheumatoid Arthritis
PI: Dr. Rahul K. Verma
CO-PI: Dr. Rehan Khan
Funding Amount: 41 lakhs
Tenure: 3 years
Funding Agency: DST-SERB(CRG )
Title: Enzyme-Responsive hydrogel for site-specific drug delivery as potential therapy for Colitis
PI: Dr. Rehan Khan
CO-PI: Dr. Rahul K. Verma
Funding Amount: 43,22,120
Tenure: 3 years
Funding Agency: DST-SERB- Core Research Grant
Title: Nanoparticle-mediated inhibition of PRDX2 for selective killing of CHEK2-defective colorectal cancer cells by synthetic lethality
PI: Dr. Rehan Khan
Funding Amount: 22,16,000
Tenure: 3 years
Funding Agency: DST-SERB- Young Scientist