Faculty Directory
Dr. Subhasree Roy Choudhury
Scientist-D | Academic Coordinator
Development of target specific nanotherapeutics for epigenetic regulation of cancer. Chemoprevention and mechanism of action of drug/siRNA loaded nanoparticle mediated therapy for leukemia, neuroblastoma and glioblastoma. New drug development from natural products and combination therapy against cancer. Development and application of high-throughput functional gene-based screening for cancer. Multiple retrovirus and lentivirus mediated gene delivery for target validation and functional implication in cancer.
Contact Information :
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Email:
subhasreerc@inst.ac.in -
Google Link:
Google Link
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Targeted epigenetic nanotherapy in fusion oncoprotein rearranged leukemia and epigenetic regulation of leukemic transformation.
Our Selected Related Publications:
1. ACS Appl Mater Interfaces. 2024, Just Accepted https://doi.org/10.1021/acsami.4c18737
2.Nano Today; 2024, 59, 102542 https://doi.org/10.1016/j.nantod.2024.102542.
3. Nanoscale, 2024, 16 (42), 19743-19755; https://doi.org/10.1039/D4NR02692F
4. Applied Materials Today, 2020, 21, 100847. https://doi.org/10.1016/j.apmt.2020.100847
5. Journal of Materials Chemistry B, 2020, 8, 8658 – 8670. https://doi.org/10.1039/D0TB01177K
6. ACS Appl Mater Interfaces. 2020, 12, 25633. https://doi.org/10.1021/acsami.0c06186
7. Mol. Pharmaceutics (ACS), 2020,2, 604. DOI:10.1021/acs.molpharmaceut.9b01071. -
Nanotherapeutic intervention for epigenetic regulation of Parkinson’s Disease
1. Carbohydrate Polymers, 2024, 346, 122575 10.1016/j.carbpol.2024.122575
2. ACS Applied Materials & Interfaces, 2024, 16 (30), 38880-38892. https://doi.org/10.1021/acsami.3c18226
3. ACS Appl. Nano Mater, 2024, 7, 8, 8730–8737. https://doi.org/10.1021/acsanm.4c00137
4. ACS Chem. Neurosci, 2023, 15, 71. https://doi.org/10.1021/acschemneuro.3c00545
5. ACS Appl. Mater. Interfaces 2023, 15, 10, 12708–12718: https://doi.org/10.1021/acsami.2c20990
6. Biomaterials Advances, 2022, 133 112602 https://doi.org/10.1016/j.msec.2021.112602;
7. Carbohydrate Polymers, 2021, 254: 1174 https://doi.org/10.1016/j.carbpol.2020.117435
8. Nanomed: Nanotech.Biol and Med. 2020, 24, 102088. https://doi.org/10.1016/j.nano.2019.102088. -
Polycomb repressive complex targeted epigenetic nanotherapy for inhibition of solid tumours
1. Biomater. Sci., 2022,10, 5301-5317 DOI: https://doi.org/10.1039/D1BM02006D
2. ACS Biomaterials Science & Engineering 2022, 8, 9, 3810–3818 https: //doi.org/ 10.1021/acs biomaterials.2c00165.
3. ACS Medicinal Chemistry Letters, 2022, 13, 7, 1109–1117 DOI: https://doi.org/10.1021/acsmedchemlett.2c00135
4. Phytomedicine, 80: 153386. DOI: https://doi.org/10.1016/j.phymed.2020.153386
5. ACS Biomater. Sci. Eng.,2020, 6, 3139. https://doi.org/10.1021/acsbiomaterials.2c00165
6. Nanoscale Adv., 2019,1, 2188-2207. DOI: 10.1039/c9na00212j
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Dr. Subhasree Roy Choudhury and group have recently shown that Polycomb protein Bmi1 is associated with advanced prognosis of acute myeloid leukemia (AML). Polyethylenimine (PEI)-stabilized Bmi1 siRNA-entrapped human serum albumin (HSA) nanocarriers (PEI@HSANCs) were used to protect siRNA from degradation and for epigenetic regulation-based AML therapy. Nanoform increased the transfection efficiency of Bmi1 siRNA through caveolae-mediated endocytosis and enhanced Bax translocation into the mitochondria, enhanced caspase 3-mediated apoptosisand inhibited Bcl2. The molecular analysis reveals the downregulation of polycomb proteins, Bmi1 and EzH2, along with inhibition of H3K27me3 and H2AK119ub1 through ubiquitin-mediated degradation of Bmi1, which is reversed by a proteasome inhibitor. Further mechanistic studies by Chromatin immunoprecipitation (ChIP) assay established a crucial role of transcription factor, C-Myb and Bmi1, as its direct targets for maintenance and progression of AML. Decreased leukemic stem cells marker (CD45+) and an increase in the myeloid differentiating marker expression (CD11b+) in the bone marrow,withdrawal of epigenetic repression through ubiquitin proteasomal pathway potentiating a novel antileukemic therapy were established in in vivo AML xenograft model.
More details: ACS Appl. Mater. Interfaces 2020, 12, 23, 25633–25644. https://doi.org/
10.1021/acsami.0c06186 -
Dr. Subhasree Roy Choudhury and group have shown targeted photodynamic therapy (PDT) with potential photosessitizer nanocomposite inducing PP2A-mediated BMI1 ubiquitination/degradation demonstrating an epigenetic driven nanotherapeutic approach in colorectal cancer treatment.
More details: ACS Biomater. Sci. Eng. 2020, 6, 5, 3139–3153. https://doi.org/10.1021/acsbiomaterials.9b01844
Current Group Members
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SUSHMA SHARMA
Email: sushma.ph24213@inst.ac.in
Reg. No.: PH24213
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POOJA
Email: pooja.ph23226@inst.ac.in
Reg. No.: PH23226
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MS. DEVANGI GHOSH
Email: devangi.ph22220@inst.ac.in
Reg. No.: PH22220
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MR. MOHD. AYOUB
Email: ayoub.ph22218@inst.ac.in
Reg. No.: PH22218
Alumni
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JASMINE KAUR
Reg. No.: IN-2024/17
Designation: Intern Student
May 2024 - Jul 2024
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MR. MOHAMMED NADIM
Reg. No.: PH16240
Designation: PhD Scholar
Jan 2017 - Apr 2023
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MR. AVINASH CHANDRA KUSHWAHA
Reg. No.: PH17210
Designation: PhD Scholar
Aug 2017 - Mar 2024
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MS. BABITA KAUNDAL
Reg. No.: Ph16209
Designation: PhD Scholar
Aug 2016 - Jun 2022
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1.
CD33 targeted EzH1 regulated nanotherapy epigenetically inhibits fusion oncoprotein (AML1 ETO) rearranged acute myeloid leukemia in both in vitro and in vivo Patient Derived Xenograft models. , Kushwaha A, Mrunalini B, ghosh Devangi, Malhotra P, Karmakar S, Roy Choudhury S , Nano Today; , 2024 , 59, , 102542 , https://doi.org/10.1016/j.nantod.2024.102542. -
2.
Antibody conjugated targeted nanotherapy epigenetically inhibits calpain-mediated mitochondrial dysfunction to attenuate Parkinson’s disease. , Biswal L, Sahu VK, Sardoiwala MN, Karmakar S, Roy Choudhury S , Carbohydrate Polymers , 2024 , 346 , 122575 , https://doi.org/10.1016/j.carbpol.2024.122575 -
3.
Immunomodulator-Derived Nanoparticles Induce Neuroprotection and Regulatory T Cell Action to Alleviate Parkinsonism. , , Sardoiwala MN, Biswal L, Roy Choudhury S , ACS Applied Materials and interfaces , 2024 , 16, 30 , 38880-38892 , https://doi.org/10.1021/acsami.3c18226 -
4.
Bone marrow targeted nanocomposite abrogates C-Myb-Survivin cross talk in MLL-AF9 rearranged Acute Myeloid Leukemia in in vitro and in vivo Patient Derived Xenograft model , Kushwaha, Avinash Chandra ; Boddu, Mrunalini ; Malhotra, Pankaj; Karmakar, Surajit; Roy Choudhury, Subhasree , ACS Applied Materials and Interfaces , 2024 , Just accepted , https://doi.org/10.1021/acsami.4c18737 -
5.
CD56-targeted in vivo genetic engineering of natural killer cells mediates immunotherapy for acute myeloid leukemia , Kushwaha AC, Boddu M, Malhotra P, Roy Choudhury S , Nanoscale , 2024 , 16 (42) , 19743-19755 , https://doi.org/10.1039/D4NR02692F -
6.
Hytrin Nanoformulation reduces nitrated Synucleinopathy Through Chaperon-Mediated Autophagy. , Sardoiwala MN, Biswal L, Karmakar S, Roy Choudhury S , ACS Appl. Nano Mater , 2024 , 7, 8 , 8730-37 , https://doi.org/10.1021/acsanm.4c00137 -
7.
Melatonin-Polydopamine Nanoformulation Prevents Retinal Neurodegeneration in a Preclinical Model of Diabetic Retinopathy , Sardoiwala, MN, Biswal L, Sahu VK, Boddu M, Roy Choudhury S, Karmakar S , ACS Appl. Nano Mater , 2024 , 7 , 6983 , https://doi.org/10.1021/acsanm.3c06068 -
8.
Improved melatonin delivery by size controlled polydopamine nanoformulation attenuate preclinical diabetic retinopathy. , Sardoiwala MN, Nagpal S, Bhatt B, Roy Choudhury S, Karmakar S , ACS Molecular Pharmaceutics , 2023 , 20 ,6 , 2899-2910. , https://doi.org/10.1021/acs.molpharmaceut.2c01039 -
9.
FTY720 Nanoformulation Induces O-GlcNacylation of Synuclein to Alleviate Synucleinopathy , Sardoiwala MN, Boddu M, Biswal L, Karmakar S, Roy Choudhury S , ACS Chem. Neurosci , 2023 , 15 , 71 , https://doi.org/10.1021/acschemneuro.3c00545 -
10.
Reconstituted Super Paramagnetic Protein “Magnetotransferrin” for Brain Targeting to Attenuate Parkinsonism: , Mohammed Nadim Sardoiwala, Ankur Sood, Liku Biswal, Subhasree Roy Choudhury*, and Surajit Karmakar* , 2023 , just accepted: , ACS Applied Materials & Interfaces , https://doi.org/10.1021/acsami.2c20990 -
11.
Nano-emulsified Genistein and Vitamin D mediated epigenetic regulation to inhibit osteoporosis: , Avinash Chandra Kushwaha, Soni Jignesh Mohanbhai, Mohammed Nadim Sardoiwala, Mahendran Jaganathan, Surajit Karmakar , Subhasree Roy Choudhury * , 2022 , just accepted , ACS Biomaterials Science - Engineering , https://doi.org/10.1021/acsbiomaterials.2c00165 -
12.
Colon targeted chitosan-melatonin nanotherapy for preclinical Inflammatory Bowel Disease: , Soni Jignesh Mohanbhai,Mohammed Nadim Sardoiwala,Shiwangi Gupta, Nishith Shimali,Subhasree Roy Choudhury,Shyam Sundar Sharma ,Prasenjit Guchhait,Surajit Karmakar* , 2022 , just accepted: , Biomaterials Advances , https://doi.org/10.1016/j.bioadv.2022.212796 -
13.
Mitochondria-targeting nano therapy altering IDH2 mediated EZH2/EZH1 interaction as precise epigenetic regulation in Glioblastoma: , Babita Kaundal, Surajit Karmakar*, Subhasree Roy Choudhury* , 2022 , just accepted: , Biomaterials Science , https://doi.org/10.1039/D1BM02006D -
14.
4-Oxo-fenretinide-Loaded Human Serum Albumin Nanoparticles for the Inhibition of Epithelial–Mesenchymal Transition in Neuroblastoma Xenografts: , Atul Dev, Mohammed Nadim Sardoiwala, Mrunalini Boddu, Soni Jignesh Mohanbhai, Subhasree Roy Choudhury*, Surajit Karmakar* , 2022 , just accepted: , ACS Applied Nano Materials , https://doi.org/10.1021/acsanm.2c01596 -
15.
Melatonin mediated inhibition of EZH2-NOS2 crosstalk attenuates inflammatory bowel disease in preclinical in vitro and in vivo models: , Mohammed Nadim Sardoiwala, Soni Jignesh Mohanbhai, Avinash Chandra Kushwaha, Atul Dev, Liku Biswal, Shyam Sundar Sharma, Subhasree Roy Choudhury*, Surajit Karmakar * , 2022 , just accepted: , Life Science , https://doi.org/10.1016/j.lfs.2022.120655 -
16.
Nanoacetylated N-(4-Hydroxyphenyl) Retinamide Modulates Histone Acetylation–Methylation Epigenetic Disparity to Restrict Epithelial–Mesenchymal Transition in Neuroblastoma: , Atul Dev, Mohammed Nadim Sardoiwala, Angela Sharma, Soni Jignesh Mohanbhai, Surajit Karmakar*, Subhasree Roy Choudhury* , 2022 , just accepted: , ACS Medicinal Chemistry Letters , https://doi.org/10.1021/acsmedchemlett.2c00135 -
17.
Hytrin loaded polydopamine-serotonin nanohybrid induces IDH2 mediated neuroprotective effect to alleviate Parkinson's disease: , Mohammed Nadim Sardoiwala,Soni JIgnesh Mohanbhai ,Surajit Karmakar,Subhasree Roy Choudhury * , 2022 , just accepted , Materials Science and Engineering: C , https://doi.org/10.1016/j.msec.2021.112602 -
18.
Coupled catalytic dephosphorylation and complex phosphate ion-exchange in networked hierarchical lanthanum carbonate grafted asymmetric bio- composite membrane: , Anup K. Srivastava,Babita Kaundal ,Mohammed Nadim Sardoiwala,Subhasree Roy Choudhury,Surajit Karmakar* , 2022 , 15;606(Pt 2):: 2024-2037. , Journal of Colloid and Interface Science, 2022 Jan , https://doi.org/10.1016/j.jcis.2021.09.173 -
19.
Genistein nanoformulation promotes selective apoptosis in oral squamous cell carcinoma through repression of 3PK-EZH2 signalling pathway: , Atul Dev, Mohammed Nadim Sardoiwala, Avinash Chandra Kushwaha,Surajit Karmakar*, Subhasree Roy Choudhury* , 2021 , 80: 153386 , Phytomedicine , https://doi.org/10.1016/j.phymed.2020.153386 -
20.
Chitosan nanocarrier for FTY720 enhanced delivery retards Parkinson’s disease via PP2A-EzH2 signaling in vitro and ex vivo: , Mohammed Nadim Sardoiwala,Surajit Karmakar, Subhasree Roy Choudhury* , 2021 , 254: 117435 , Carbohydrate Polymers , https://doi.org/10.1016/j.carbpol.2020.117435 -
21.
Pre-coating of protein modulate patterns of corona formation, physiological stability and cytotoxicity of Silver nanoparticles: , Arpit Bhargava,Atul Dev,Soni Jignesh Mohanbhai ,Vikram Pareek,Navin Jain ,Subhasree Roy Choudhury,Jitendra Panwar ,Surajit Karmakar , 2021 , 144797 , Stoten , https://doi.org/10.1016/j.scitotenv.2020.144797 -
22.
Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models: , Anup K. Srivastava, Subhasree Roy Choudhury*,Surajit Karmakar* , 2021 , 194,2021: 108372 , Neuropharmacology , https://doi.org/10.1016/j.neuropharm.2020.108372 -
23.
Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model: , Mohanbhai Jignesh Soni, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury,Shyam Sunder Sharma, Surajit Karmakar , 2021 , 124, 2021: 112038. , Materials Science and Engineering: C , https://doi.org/10.1016/j.msec.2021.112038 -
24.
Alpha-ketoglutarate decorated iron oxide-gold core-shell nanoparticles for active mitochondrial targeting and radiosensitization enhancement in hepatocellular carcinoma: , Ankur Sood,Atul Dev ,Mohammed Nadim Sardoiwala , Subhasree Roy Choudhury, Shubhra Chaturvedi,Anil Kumar Mishra,Surajit Karmakar , 2021 , 129, 2021,: 112394. , Materials Science and Engineering: C , https://doi.org/10.1016/j.msec.2021.112394 -
25.
Nanoformulation of EPZ011989 attenuates EZH2-c-Myb epigenetic interaction by proteasomal degradation in Acute Myeloid Leukemia.: , Kaundal B; Srivastava A; Dev A; Mohanbhai Soni J; Karmakar S; Roy Choudhury S* , 2020 , 2: 604-621 , Mol. Pharmaceutics , https://doi.org/10.1021/acs.molpharmaceut.9b01071 -
26.
Paclitaxel nanocrystalline assemblies as a potent Transcatheter arterial chemoembolization (TACE) candidate for unresectable hepatocellular carcinoma.: , Dev A, Sood A, Roy Choudhury S, Karmakar S* , 2020 , 107: 110315 , Materials Science - Engineering C , https://doi.org/10.1016/j.msec.2019.110315 -
27.
Near-Infrared Responsive Dopamine/Melatonin-Derived Nanocomposites Abrogating in Situ Amyloid β Nucleation, Propagation, and Ameliorate Neuronal Functions.: , Srivastava AK, Roy Choudhury S* , 2020 , 12: 5658-5670 , ACS Appl. Mater. Interfaces , https://doi.org/10.1021/acsami.9b22214 -
28.
Hypericin-Loaded Transferrin Nanoparticles Induce PP2A-Regulated BMI1 Degradation in Colorectal Cancer-Specific Chemo-Photodynamic Therapy: , Mohammed Nadim Sardoiwala, Avinash Chandra Kushwaha, Atul Dev, Nishith Shrimali, Prasenjit Guchhait, Surajit Karmakar* , and Subhasree Roy Choudhury* , 2020 , 6: 3139-3153 , ACS Biomater. Sci. Eng , https://doi.org/10.1021/acsbiomaterials.9b01844 -
29.
κ-carrageenan-C phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring.: , Atul Dev,Soni J Mohanbhai,Avinash C. Kushwaha,Mohammed Nadim Sardoiwala ,Subhasree Roy Choudhury* ,Surajit Karmakar* , 2020 , 109: 121-131 , Acta Biomaterialia , https://doi.org/10.1016/j.actbio.2020.03.023 -
30.
PRT4165 nanocomposite promoting epigenetic retardation through proteasomal depletion of polycomb in acute myeloid leukemia : , Avinash Chandra Kushwaha, Babita Kaundal, Atul Dev, Anup Kumar Srivastava, Soni Jignesh Mohanbhai, Surajit Karmakar*, and Subhasree Roy Choudhury* , 2020 , Applied Materials Today , Just accepted -
31.
Recuperative Effect of Metformin loaded Polydopamine Nanoformulation promoting EZH2 mediated Proteasomal Degradation of phospho-α-Synuclein in Parkinson's disease model: , Md Nadim Sardoiwala ,Anup K Srivastava ,Babita Kaundal ,Surajit Karmakar ,Subhasree Roy Choudhury* , 2020 , 24: 102088 , Nanomedicine: Nanotechnology, Biology, and Medicine , 10.1016/j.nano.2019.102088. -
32.
Melatonin/Polydopamine Nanostructures for Collective Neuroprotection based Parkinson’s Disease Therapy.: , Srivastava, AK, Roy Choudhury S*, Karmakar S* , 2020 , Biomaterials Science , https://doi.org/10.1039/C9BM01602C -
33.
Epigenetic Regulation of Bmi1 by Ubiquitination and Proteasomal Degradation Inhibit Bcl 2 in Acute Myeloid Leukemia: , Avinash Chandra Kushwaha,Soni Jignesh Mohanbhai,Mohammed Nadim Sardoiwala,Ankur Sood,Surajit Karmakar* and,Subhasree Roy Choudhury* , 2020 , 23,: 25633–25644. , ACS Applied Materials and Interfaces, 2020, 12 , https://dx.doi.org/10.1021/acsami.0c06186 -
34.
A non-viral nano-delivery system targeting epigenetic methyltransferase EZH2 for precise Acute Myeloid Leukemia therapy.: , Babita Kaundal, Avinash Chandra Kushwaha, Anup K Srivasatava, Surajit Karmakar, Subhasree Roy Choudhury* , 2020 , just accepted: , Journal of Materials Chemistry B -
35.
Nanostructure Endows Neurotherapeutic Potential in Optogenetics: Current Development and Future Prospects.: , Mohammed Nadim Sardoiwala, Anup K. Srivastava, Surajit Karmakar*, Subhasree Roy Choudhury* , 2019 , 10, 8: 3375-3385.. , ACS Chem. Neurosci , https://doi.org/10.1021/acschemneuro.9b00246 -
36.
NIR-responsive Indocyanine green-GenisteinNanoformulation controlling Polycomb epigenetic machinery for efficient Photo-Chemo-Combotherapy of Glioblastoma.: , Kaundal B, Srivastava AK, Sardoiwala N Md, Karmakar S, Roy Choudhury S* , 2019 , 1: 2188-2207. , Nanoscale Advances , https://doi.org/10.1039/C9NA00212J -
37.
Disulfide-Bridged Chitosan-Eudragit S-100 Nanoparticles for Colorectal Cancer.: , Sood A, Dev A, Mohanbhai SJ, Shrimali N, Kapasiya M, Kushwaha A, Roy Choudhury S, Guchhait P, Karmakar S* , 2019 , 0: 6409-6417.. , ACS Appl. Nano Mater, 2 , https://doi.org/10.1021/acsanm.9b01377 -
38.
Development of engineered nanoparticles expediting diagnostic and therapeutic applications across blood brain barrier.: , >Mohammed Nadim Sardoiwala Babita Kaundal and Subhasree Roy Choudhury* , 2018 , Elsevier Press, 2018: 696-709. , Handbook of Nanomaterials for Industrial Applications , https://doi.org/10.1016/B978-0-12-813351-4.00038-9 -
39.
1,3β Glucan anchored, paclitaxel loaded chitosan nanocarrier endows enhanced hemocompatibility with efficient anti-glioblastoma stem cells therapy: , Pankaj K. Singh,Anup K. Srivastava,Atul Dev,Babita Kaundal,Subhasree Roy Choudhury* ,Surajit Karmakar* , 2018 , 180: 365-375 , CarbohydrPolym , 10.1016/j.carbpol.2017.10.030 -
40.
Superior Bactericidal Efficacy of Fucose-Functionalized Silver Nanoparticles against Pseudomonas aeruginosa PAO1 and Prevention of Its Colonization on Urinary Catheters.: , Bhargava A, Pareek V,Panwar J, Karmakar S. , 2018 , 10(35): 29325-29337. , ACS Appl Mater Interfaces , 10.1021/acsami.8b09475
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1.
Recent advancement of hybrid nanoparticles synthesis and applications in lung cancer management. , Gouri, A.; Sharma, A.; Boddu, M.; Mahendran, J.; Mohanbhai, S.J.; Sardoiwala, M.N.; Roy Choudhury, S.; Karmakar S. , 2024 , 179 , https://doi.org/10.1016/B978-0-323-95303-0.00010-1 -
2.
Fabrication of Multifunctional Silica Nanocarriers for Cancer Theranostics. CRC Press, Functionalized Nanomaterials II: Applications, , Kushwaha AC, Sood A, Roy Choudhury S. , 2021 , 45 -
3.
Insight into Covalent/Non-covalent Functionalization of Silica Nanoparticles for Neurotherapeutic and Neurodiagnostic Agents. CRC Press, Taylor & Francis, England. Functionalized Nanomaterials I: Fabrications, 215-224 , Srivastava AK, Kaundal B, Khanna G, Choudhury SR and Karmakar S. , 2021 -
4.
Nanobiosensors and Its Application in Agriculture and Food. Nanopharmaceuticals,: , Sardoiwala N Md, Srivastava AK, Roy Choudhury S, Karmakar S* , 2020 , 8: 344 , 21st Century Nanoscience – A Handbook; Nanopharmaceuticals, Nanomedicine, and Food Nanoscience;Taylor and Francis Group, 1st Ed , https://doi.org/10.1201/9780429351587 -
5.
Development of engineered nanoparticles expediting diagnostic and therapeutic applications across blood brain barrier.Handbook of Nanomaterials for Industrial Applications, , Sardoiwala MN, Kaundal B, Choudhury SR , 2018 , 696-709 -
6.
Nanomaterial toxicity in Microbes, Plants and Animals. Nanoscience in Food and Agriculture, , Kaundal B, Dalai S and Choudhury SR*. , 2017 , 5 , 243-266 -
7.
Role of angiogenesis in the pathogenesis of glioblastoma and antiangiogenic therapies for controlling glioblastoma. In Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeut: , Roy Choudhury S,Karmakar S, Banik NL, Ray SK , 2010 , 217-241, ISBN-978-1-4419-0409-6 , Publisher: Springer; 1 edition
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1.
c-Myb interaction with histone acetyltransferase p300 regulates its transcriptional activities in human leukaemic cells.: New directions in leukemia research. March 30-April 2nd, Noosa, QLD, Australia. , Ding Jianmin, Roy Choudhury S, Cao Lu, and Gonda Tom , 2014 -
2.
Antineoplastic protein toxin (Toxin CM28) from Vipera russelli russelli venom.: 38th Annual Conference of the Indian Pharmacological Society, Chennai, December 28-30 , Roy Choudhury S and Gomes A , 2005 -
3.
Pharmacological characterization of a heat stable protein toxin (Toxin CM 28) from Russells viper venom CM 28) from Russells viper venom.: 36th Annual Conference of the Indian Pharmacological Society, Delhi, December, 5-7 , Roy Choudhury S and Gomes A , 2003 -
4.
Hepatoprotective, immunostimulatory and antioxidant activities of Tinospora cordifolia in CCL4 intoxicated mature albino rats. XIII Annual Conference of the Physiological Society of India,: Kolkata, February 23-24 , Roy Choudhury S and Bishayi B , 2002 -
5.
Functional validation of Myb target genes in myeloid leukaemic transformation. New directions in leukemia research.: March 30-April 2nd, Noosa, QLD, Australia , Roy Choudhury S and Gonda Tom , (2014) -
6.
Synergistic efficacy of HA14-1 and apigenin in inhibiting angiogenic factors and increasing apoptosis in neuroblastoma cells.: Frontiers in Neuroscience Conference. March 05 - 07, Atlanta, USA , Davis KA, Karmakar S, Roy Choudhury S, Banik NL and Ray SK , (2010) -
7.
Activation of both extrinsic and intrinsic pathways of apoptosis in human neuroblastoma SH-SY5Y cells in culture as well as in xenografts in athymic nude mice.: Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 , Roy Choudhury S, Karmakar S, Banik NL, Ray SK , (2009) -
8.
Combination of valproic acid and taxol or nanotaxol effectively inhibited angiogenic factors and increased apoptosis in glioblastoma U87MG cells in culture and xenografts in nude mice.: Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 , Roy Choudhury S, Karmakar S, Banik NL, Ray SK , (2009) -
9.
Small Molecule Inhibitor of Bcl-2 Enhances Efficacy of Genistein for Apoptosis in Neuroblastoma SH-SY5Y and SK-N-BE2 Cell lines.: , Mohan N, Karmakar S, Roy Choudhury S, Banik NL , Ray SK , (2009) -
10.
Combination of sorafenib and genistein inhibits angiogenesis and triggers multiple molecular mechanisms for apoptosis in human malignant neuroblastoma SK-N-DZ and SH-SY5Y cell lines presented: , Roy Chudhury S, Karmakar S, Banik NL, Ray SK , (2009) -
11.
Combination of Bcl-2 inhibitor and apigenin activated extrinsic and intrinsic pathways of apoptosis in neuroblastoma SK-N-DZ cells.: Presented at the 40th Annual ASN Meeting, Charleston, SC - March 7-11 , Roy Choudhury S, Davis K, Karmakar S, Deeconda A, Banik NL, Ray SK , (2009) -
12.
Combination of N-(4-hydroxyphenyl) retinamide and genistein increases apoptosis in Ewing’s sarcoma SK-N-MC cells in culture and xenografts in athymic nude mice.: Presented at the 100th AACR Annual Meeting Denver, CO, April 18-22 , Roy Choudhury, Karmakar S, Tomlinson S, Banik NL, Ray SK , (2009) -
13.
Combination of valproic acid and taxol or nanotaxol induced differentiation and apoptosis in glioblastoma LN18 and T98G cells presented at the 40th Annual ASN Meeting,: Charleston, SC - March 7-11 , Roy Choudhury S and Karmakar S, Banik NL, Ray SK , (2009) -
14.
A new protein toxin (drCT1) from Dabuia russellii venom having antiproliferative and apoptogenic activity in15th World Congress on Animal,: Plant & Microbial Toxins, International Society on Toxinology, Glasgow, UK. July 27 , Roy Choudhury S, Dasgupta SC, Saha A, Giri B, Gomes A , (2006) -
15.
Structure and functional characterization of a heat stable antineoplastic protein toxin (Toxin CM28) from Russells viper venom.: 37th Annual Conference of the Indian Pharmacological Society, Kolkata, January 14-16 , Roy Choudhury S, and Gomes A , (2005)
Awarded Gold Medal by University of Calcutta for securing the 1st Class 1st rank in M.Sc Physiology in 2001.
Awarded with Dr. D.N. Mallick Memorial Gold Medal by the Physiological Society of India for securing the 1st Class 1st rank in M.Sc Physiology in 2001.
Awarded with Prof. A. K. Mukherjee Memorial Cup by the 6th Annual Scientific Meet Committee, Calcutta in B.Sc examination in Physiology in 1999.
Awarded National Scholarship by the West Bengal Board of Secondary Education in Madhyamik examination in 1994.
Awarded Junior Research Fellowship and Senior Research Fellowship by UGC.
Post Doctoral Fellow:The School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, QLD 4102,, Australia (2012 to 2014 )
Post Doctoral Fellow: Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201,, USA (2010 to 2011 )
Post Doctoral Fellow:Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC 29209,, USA (2008 to 2010 )
Post Doctoral Fellow: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425,, USA. (2007 to 2008 )
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Title: Targeted nanotherapy controlling epigenetic regulation of pediatric solid tumor
PI: Dr. Subhasree Roy Choudhury
CO-PI: Prof.Surajit Karmakar
Funding Amount: 47 Lakhs
Tenure: 3 years
Funding Agency: ICMR
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Title: CD133 Targeted Aptamer Tethered Epigenetic based novel nanotherapy for glioblastoma.
PI: Dr. Subhasree Roy Choudhury
CO-PI: Prof. Surajit Karmakar
Funding Amount: 30 lakhs
Tenure: 3 years
Funding Agency: CSIR
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Title: Nanotherapy for controlling epigenetic regulation by polycomb in Myb mediated leukemia
PI: Dr. Subhasree Roy Choudhury
Funding Amount: 29 Lakhs
Tenure: 3 years
Funding Agency: SERB DST
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Title: Identification of Polycomb and c-Myb signalling and their targeted nanotherapy in leukemogenesis
PI: Dr. Subhasree Roy Choudhury
CO-PI: Prof. Surajit Karmakar
Funding Amount: 33.04 Lakhs
Tenure: 3 years
Funding Agency: DBT
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Title: Construction of in vitro and in vivo genetic and epigenetic markers based bispecific CAR-T cells for acute lymphocytic leukemia immunotherapy
PI: Prof. Surajit Karmakar
CO-PI: Dr. Subhasree Roy Choudhury
Funding Amount: 46 Lakhs
Tenure: 3 Years
Funding Agency: DBT
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Title: Development of Fluorescence and NIR sensitive nanoplatform for imaging and therapy of brain tumors
PI: Prof. Surajit Karmakar
CO-PI: Dr. Subhasree Roy Choudhury
Funding Amount: 49 Lakhs
Tenure: 3 years
Funding Agency: ICMR
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Title: Controlling Diabetic Retinopathy (DR) through novel dopamine-melatonin combination nano therapy
PI: Prof. Surajit Karmakar
CO-PI: Dr. Subhasree Roy Choudhury
Funding Amount: 59 Lakhs
Tenure: 3 years
Funding Agency: DBT
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Title: Controlling Diabetic Retinopathy (DR) through novel VEGF targeted aptamer tethered Pazopanib nanotherapy
PI: Dr. Surajit Karmakar
CO-PI: Dr. Subhasree Roy Choudhury
Funding Amount: 75 Lakhs
Tenure: 3 years
End Date: 31-Dec-2027
Funding Agency: ICMR
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Title: Development of CRISPR based novel nanotherapy for Parkinson’s disease
PI: Dr. Surajit Karmakar
CO-PI: Dr. Subhasree Roy Choudhury
Funding Amount: 75 Lakhs
Tenure: 3 years
End Date: 31-Dec-2027
Funding Agency: ICMR