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Dr. Jiban Jyoti Panda

Assistant Professor (Scientist-D)

Ours is a neuronanotherapeutics group where we try to develop different nanostructures for treating CNS associated disorders like glioblastoma, Alzheimer's etc. Our groups other interests involve design and synthesis novel biocompatible and multifunctional nanostructures, mostly peptide based self-assembled nanostructures for achieving effective drug delivery across the blood brain barrier. We also work towards the development of theranostic nanosystems for effective imaging and therapy of dreaded diseases like cancer, neurodegenerative disorders, cataract etc. Besides, our group also work towards the development of various nanosensing platforms based on SERS, electrochemical or fluorescence based techniques for aiding detection and diagnosis of glioblastoma, neurodegenerative disorders etc.

CONTACT INFORMATION :

Research Interest

  • Ours is a Neuro-nanotherapeutics group, where we strive to develop nanomedicine for targeting various neurological disorders like glioblastoma, brain stroke, Alzheimer etc. Our aim is to develop novel systems and methods for achieving effective delivery across the blood brain barrier for treating glioblastomas and other neurodegenerative disorders. Our other important aim is to develop biocompatible drug delivery systems for effective cancer therapy. Developing smart and biocompatible scaffolds for tissue engineering applications is also one of our research aims.

Research Highlights

  • Dr Panda and group work towards the development of different nanomedicine based platforms for combating neurological disorders such as delivery across the blood brain barrier; targeted nanomedicine for anti-glioma therapy; stimuli responsive on demand drug delivery platforms; nanomedicine targeting the protein aggregation disorders; theranostic nanostructures as sensing, diagnosis and therapeutic platforms.

PhD Students

  • Ms. Taru Dube

    Email: taru.ph15213@inst.ac.in

    Reg. No.: PH15213

    Working Since Jul, 2015

  • Ms. Sonika Chibh

    Email: sonika.ph16241@inst.ac.in

    Reg. No.: Ph16241

    Working Since Jan, 2017

  • Ms. Manju sharma

    Email: manju.ph17206@inst.ac.in

    Reg. No.: PH17206

    Working Since Aug, 2017

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  1. Effect of Particle Size and Viscosity of Suspensions on Topical Ocular Bioavailability of Budesonide, a Corticosteroid: Vooturi S, Bourne D, Panda JJ, Choi S , Kim H, Yandrapu SK, Kompella UB, (2020) Journal of Ocular Pharmacology and Therapeutics, Journal of Ocular Pharmacology and Therapeutics: .

  2. Comprehensive evaluation of chitosan nanoparticle based phage lysin delivery system; a novel approach to counter S. pneumoniae infections: Gondil VS, Dube T, Panda JJ, Yennamalli RM, Harjai K, Chhibber S, (2020) Int J Pharm., 573: 118850.

  3. Redox-Responsive Dipeptide Nanostructures toward Targeted Cancer Therapy: Chibh S, Kour A, Yadav N, Kumar P, Yadav P, Chauhan VS, Panda JJ, (2020) ACS Omega, 5: 3365-3375.

  4. Cholesterol bound Plasmodium falciparum co-chaperone 'PFA0660w' complexes with major virulence factor 'PfEMP1' via chaperone 'PfHsp70-x'.Behl A: .Behl A, Kumar V, Bisht A, Panda JJ, Hora R, Mishra PC., (2019) Sci Rep, 9(1): 2664.

  5. Short peptide-based smart targeted cancer nanotherapeutics: a glimmer of hope.: Mishra J, (2019) Ther Deliv, 10(3): 135-138. DOI: 10.4155/tde-2019-0005

  6. Nanotheranostics, a future remedy of neurological disorders.: Sharma M, Dube T, Chibh S, Kour A, Mishra J, (2019) Expert Opin Drug Deliv., 16(2): 113-128. DOI: 10.1080/17425247.2019.1562443

  7. Gold Nano-/Micro-Roses on Levodopa Microtubes for SERS-Based Sensing of Gliomas: Taru Dube, Nitin Kumar, Avneet Kour, Jibanananda Mishra, Manish Singh,Bhanu Prakash,Jiban J Panda, (2019) ACS Appl. Nano Mater, 2,5: 2663. DOI: 10.1021/acsanm.9b00155

  8. Carrier-free self-built aspirin nanorods as anti-aggregation agents towards alpha-crystallin-derived peptide aggregates: potential implications in non-invasive cataract therapy: Anjali Bisht, Manju Sharma, Shikha Sharma, Md. Ehesan Ali,Jiban J. Panda, (2019) Journal of Materials Chemistry B, 7: 6945-6954. DOI: 10.1039/C9TB01435G

  9. Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice.: Varshney A, Singh AK, Yadav N, Bihari C, Biswas S, Sarin SK, Chauhan VS., (2018) Hepatology, 67(4): 1392-1407. DOI: 10.1002/hep.29643

  10. PHISTc protein family members localize to different subcellular organelles and bind Plasmodium falciparum major virulence factor PfEMP-1: Kumar V, Kaur J, Singh AP, Singh V, Bisht A, Mishra PC, Hora R. FEBS J., (2018) 285(2): 294-312. DOI: 10.1111/febs.14340

  11. Arginine-α, β-dehydrophenylalanine Dipeptide Nanoparticles for pH-Responsive Drug Delivery.: Singh PK, Chibh S, Dube T, Chauhan VS, (2018) Pharm Res., 35(2): 35. DOI: 10.1007/s11095-017-2299-8

  12. Plasmodium falciparum protein 'PfJ23' hosts distinct binding sites for major virulence factor 'PfEMP1' and Maurer's cleft marker 'PfSBP1': .Kaur J, Kumar V, Singh AP, Singh V, Bisht A, Dube T, Behl A, Mishra PC, Hora R., (2018) Pathog Dis., 76(9): . DOI: 10.1093/femspd/fty090

  13. Efficacy of Dipeptide-Coated Magnetic Nanoparticles in Lung Cancer Models Under Pulsed Electromagnetic Field.: Baskar G, Ravi M, Khatri A, Dev B, Santosham R, Sathiya S, Babu CS, Chauhan VS, Rayala SK, Venkatraman G., (2017) Cancer Invest., 35(6): 431-442. DOI: 10.1080/07357907.2017.1318894

  14. Nanoparticles generated from a tryptophan derivative: physical characterization and anti-cancer drug delivery: Dube T, Mandal S, (2017) Amino Acids, 49(5): 975-993. DOI: 10.1007/s00726-017-2403-8.

  15. Receptor Targeted Polymeric Nanostructures Capable of Navigating across the Blood-Brain Barrier for Effective Delivery of Neural Therapeutics.: Dube T, Chibh S, Mishra J, (2017) ACS Chem Neurosci., 8(10): 2105-2117. DOI: 10.1021/acschemneuro.7b00207

  16. Trends in cancer nanomedicine: A.K. Ganguli,A. Shanavas, S. Roy, D. Sharma,S. Karmakar, (2016) Nano Digest, .

  17. Short peptide based nanotubes capable of effective curcumin delivery for treating drug resistant malaria.: Mukherjee TK, Chauhan VS,Alam S, (2016) Nanobiotechnology, 14: 26. DOI: 10.1186/s12951-016-0179-8

  18. Self-assembled dipeptide-based nanostructures: tiny tots with great applications: Mishra J, (2016) Ther Deliv., 7(2): 59-62. DOI: 10.4155/tde.15.85

  19. Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering.: Chauhan VS, (2014) Polym. Chem., 5: 4418-4436. DOI: 10.1039/C4PY00173G

  20. Antimicrobial activity of cationic peptides in endodontic procedures: Winfred SB, Meiyazagan G,Nagendrababu V, Deivanayagam K, Chauhan VS, (2014) Eur J Dent, 8(2): 254-60. DOI: 10.4103/1305-7456.130626

  21. Self-assembled nanoparticles based on modified cationic dipeptides and DNA: novel systems for gene delivery.: Varsheney A, Chauhan VS, (2013) Nanobiotechnology, 11(1): 18. DOI: 10.1186/1477-3155-11-18.

  22. Modified dipeptide nanoparticles: vehicles for tumor targeted delivery.: Kaul A, Kumar S, Alam S, Mishra AK, Kundu, GC, Chauhan, VS, (2013) Nanomedicine, 8(12): 1927-1942. DOI: 10.2217/nnm.12.201

  23. Dipeptide Nanogels for Anticancer Drug Delivery. In: Proceedings of 82nd Annual symposium of the National academy of sciences India (NASI) on “Nanoscience and Technology for Mankind”: Chauhan VS, (2013) .

  24. Novel dipeptide nanoparticles for effective curcumin delivery.: Alam S, Chauhan VS, (2012) International Journal of Nanomedicine, 7: 4207–4222. DOI: 10.2147/IJN.S33015

  25. Novel dipeptide nanoparticles for effective hydrophobic drug Delivery. Nanoparticle Assembly: VS Chauhan,S Alam, (2011) Fundamentals to Applications, .

  26. Designed peptides as model self-assembling nanosystems: characterization and potential biomedical applications.: Kaul A, Alam S, Babbar AK, Mishra AK, Chauhan VS., (2011) Therapeutic delivery, 2(10): 2839-48. DOI: 10.4155/tde.10.93

  27. Nanoworld of peptide self-assembly. In: souvenir of silver jubilee celebration of Jupiter Biosciences: Chauhan VS, (2010) 37-43.

  28. 3D cell growth and proliferation on a RGD functionalized nanofibrillar hydrogel based on a conformationally restricted residue containing dipeptide.: Dua R, Mishra A, Mittra B, Chauhan VS., (2010) Acs Applied Materials and Interfaces, . DOI: 10.1021/am1005173

  29. Design, Synthesis and Potential Applications of Conformationally Restricted Peptides: VS Chauhan, (2010) Journal of Peptide Science, 16: 199-199.

  30. Stimuli responsive self-assembled hydrogel of a low molecular weight free dipeptide with potential for tunable drug delivery.: Mishra A, Basu A, Chauhan VS, (2008) Biomacromolecules, 9(8): 2244–2250.

  31. Nanovesicles based on self-assembly of conformationally constrained aromatic residue containing amphiphilicdipeptides: Mishra A, Basu A, Chauhan VS., (2008) Langmuir, 24(9): 4571-4576. DOI: 10.1021/la7034533

  32. Selection of salt tolerant plants of Nicotianatabacum L. through in vitro and its biochemical characterization.: Rout GR, Senapati SK, (2008) ActaBiol Hung, 59(1): 77-92.

  33. Nanomed: Nanotechnol: SK Sahoo, S Parveen, (2007) Biol. Med, 3 (1): 20-31.

  34. The present and future of nanotechnology in human health care. Journal of Nanomedicine: Nanotechnology, Biology and Medicine.: Sahoo SK, Parveen S, (2007) 3(1): 20-31.

  1. Nanoworld of peptide self-assembly. In: souvenir of silver jubilee celebration of Jupiter Biosciences Chauhan VS, (2010) 37-43.

  1. Modified dipeptide nanoparticles: vehicles for tumor targeted drug and gene delivery: Panda JJ, (2012) .

  2. Design of low molecular weight dipeptides containing conformationally constraining residue DPhe into stimuli responsive self-assembling hydrogels with potential drug delivery applications: 1735/DEL/2008, (2008) .

  1. Enhanced and effective delivery of microrna by using ligand modified self-assembled cationic dipeptide nanoparticles in hepatocellular carcinoma (HCC),: A Varshney, JJ Panda, AK Singh, SB Rooge, S Biswas, SK Sarin, (2019) Journal of Hepatology, S411: .

  2. Nanoparticles generated from a tryptophan derivative: physical characterization and anticancer drug delivery: Taru Dube, (2017) Crick Nano Science Day,CSIO, Chandigarh., .

  3. Development of Biocompatible Peptide Based Nanostructures Capable Of Traversing the Blood Brain Barrier for Targeting Glioblastoma/Brain Tumors: Crick Nano Science Day,INST, (2016) .

  1. Multimodal Glioblastoma Therapy by Blood Brain Barrier Traversing and Glioma Targeting Anti-cancer Peptide Theranostic Nanoparticles.: at National Institute of Plant Genome Research, New Delhi., (2019) BioCARe Conclave, .

  2. Small Peptide Nanotherapeutics: For Effective Drug Delivery towards various disorders, Multi Omics approaches to Diseases” in the CME Dept. of Experimental Medicine & Biotechnology, PGIMER, Chandigarh., (2019) .

  3. Participated and had oral presentation in ASIA-ARVO: New Delhi, India, (2013) .

Fundings

  • Development of Versatile, Multifunctional and Adaptable Peptide Nanofiber Scaffolds with Potential for Promoting Neuritogenesis in Brain Injury 5, DST
    Funding Amount: 3500000
    PI: Dr. Jiban Jyoti Panda
  • Multimodal Glioblastoma Therapy by Blood Brain Barrier Traversing and Glioma Targeting Anti-cancer Peptide Theranostic Nanoparticles 3, DBT
    Funding Amount: 5200000
    PI: Dr. Jiban Jyoti Panda
  • Glioma Targeting Anticancer Peptide Theranostic Nanoparticles. 3 years, DBT Biocare
    Funding Amount: Rs 52 Lakhs
    Role PI: Dr. Manish Singh Role Co-PI: Dr. Jiban Jyoti Panda

  • 2012

    Ph.D

    Biotechnology (Nanotechnology); International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.

  • 2005

    Master of Science

    BiotechnologyUtkal University, Orissa, India (1 st Division).

  • 2003

    Bachelor of Science

    Chemistry, Zoology, Botany, [Honours]Utkal University, Orissa, India. (1 st Division)

  • Scientist D:Institute of Nano Science and Technology, Phase 10, Sector 64,, Mohali Punjab, India (March 2014 to Present till date )

  • Visiting Research Scholar:Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver,, USA (April 2013 to March 2014 )

  • UNESCO-L?Oreal International Fellow:Skagg’s School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver,, USA (December 2011 to December 2013 )

  • Research Associate:Malaria Research Lab., International Center for Genetic Engineering and Biotechnology (ICGEB), ArunaAsaf Ali Marg, JNU Complex,, New Delhi (December 2010 to December 2011 )

  • Senior Research Fellow:Malaria Research Lab., ICGEB, ArunaAsaf Ali Marg, JNU Complex, New Delhi (August 2008 to July 2010 )

  • Junior Research Fellow:Malaria Research Lab., ICGEB, ArunaAsaf Ali Marg, JNU Complex,, New Delhi (August 2006 to July 2008 )

  • Junior Research Fellow:Laboratory for Nanomedicine, Institute of Life Science, Bhubaneswar,, Orissa, India (December 2005 to May 2006 )

Awards & Honours

  • ICMR-DHR International Fellowship for Biomedical Scientists-2019

  • Best Poster Award, DBT-BIOCARE conclave 2019.
  • Best poster at Indian International Science Festival (IISF) 2017 held in Chennai during 13-16 October, 2017.
  • Best Free Paper Presentation Award, ASIA ARVO 2013, New Delhi.
  • American Association of Pharmaceutical Scientist (AAPS) Graduate Student Symposium Award in Formulation Design and Development, 2011.
  • Organization of Pharmaceutical Producers of India (OPPI) Young Scientist Award 2011.
  • The UNESCO-L’OREAL International Fellowship 2011 for Young Women in Life Sciences
  • Best poster award’ in FCS, 2011, ICGEB, New Delhi, India.
  • Received ‘Best poster award’ in NCMB 2009, at CCMB, Hyderabad.
  • Received ‘Budding Nanotechnologist award’ in ‘2nd Winter School of Nanotechnology 2009’, organized at NIPER, Chandigarh.
  • Awarded CSIR-NET, ICMR and DBT Junior Research Fellowships.
  • Awarded Certificate of Merit for reasons of outstanding academic performance and being among the top 0.1% of successful candidates of AISSCE 2000 in Biology.
  • Awarded Certificate of Merit for reasons of outstanding academic performance and being among the top 0.1% of successful candidates of AISSE 1998 in Mathematics.
  • National Merit Scholarship for outstanding performance in AISSCE 2000 by CBSE.
  • National Merit Scholarship for outstanding performance in AISSE 1998 by CBSE.

Professional Recognitions

  • Member of American Association of Pharmaceutical Scientists.
  • Member of American Chemical Society.
  • Associate Member of American Association for Cancer Research.
  • Reviewer for the journal ‘Pharmaceutical Research’.
  • Reviewer for the Journal of Ocular Pharmacology and Therapeutics.
  • Reviewer for the journal ‘Therapeutic Delivery’.

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