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Faculty Directory

Dr. Jiban Jyoti Panda

Assistant Professor (Scientist-D)

Ours is a neuronanotherapeutics group where we try to develop different nanostructures for treating CNS-associated disorders like glioblastoma, Alzheimer's etc. Our research work is directed towards the utilization of a variety of biochemical, biophysical, and molecular biology-based methodologies to generate different biomolecular based (peptide/protein/amino acid) self-assembled nanostructures for potential applications in the field of Neuro-nanomedicine. We are trying to utilize our developed bio-nano materials for different cutting-edge applications majorly to treat neurological disorders such as Alzheimer's disease, glioblastoma, cataract etc. One of the major aims of our research is to enable therapeutic molecules to cross through the Blood-Brain Barrier for the effective therapy of many dreaded and debilitating brain/CNS disorders. We also develop biomolecular-based nanoformulations for anti-Cancer therapy and neural tissue engineering targeted applications. Besides, our group also works towards the development of various nanosensing platforms based on SERS, electrochemical or fluorescence-based techniques for aiding detection and diagnosis of glioblastoma, neurodegenerative disorders etc.

CONTACT INFORMATION :

Research Interest

  • Ours is a Neuro-nanotherapeutics group, where we strive to develop nanomedicine for targeting various neurological disorders like glioblastoma, brain stroke, Alzheimer etc. Our aim is to develop novel systems and methods for achieving effective delivery across the blood brain barrier for treating glioblastomas and other neurodegenerative disorders. Our other important aim is to develop biocompatible drug delivery systems for effective cancer therapy. Developing smart and biocompatible scaffolds for tissue engineering applications is also one of our research aims.

Research Highlights

  • Dr Panda and group work towards the development of different nanomedicine based platforms for combating neurological disorders such as delivery across the blood brain barrier; targeted nanomedicine for anti-glioma therapy; stimuli responsive on demand drug delivery platforms; nanomedicine targeting the protein aggregation disorders; theranostic nanostructures as sensing, diagnosis and therapeutic platforms.

PhD Students

  • Ms. SAMRAGGI CHOUDHURY

    Email: samragi.ph20216@inst.ac.in

    Reg. No.: PH20216

    Working Since Aug, 2020

  • Ms. NIDHI AGGARWAL

    Email: nidhi.ph20215@inst.ac.in

    Reg. No.: PH20215

    Working Since Aug, 2020

  • Ms. Taru Dube

    Email: taru.ph15213@inst.ac.in

    Reg. No.: PH15213

    Working Since Aug, 2015

  • Ms. Sonika Chibh

    Email: sonika.ph16241@inst.ac.in

    Reg. No.: Ph16241

    Working Since Jan, 2017

  • Ms. Manju sharma

    Email: manju.ph17206@inst.ac.in

    Reg. No.: PH17206

    Working Since Aug, 2017

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  1. Dual Blood-Brain Barrier-Glioma Targeting Peptide-Poly(levodopamine) Hybrid Nanoplatforms as Potential Near Infrared Phototheranostic Agents in Glioblastoma.: Dube T, Kumar N, Bishnoi M, Panda JJ, (2021) Bioconjug Chem., 32: 2014-2031. DOI: 10.1021/acs.bioconjchem.1c00321

  2. Delivery of a Cancer-Testis Antigen-Derived Peptide Using Conformationally Restricted Dipeptide-Based Self-Assembled Nanotubes: Verma P, Biswas S, Yadav N, Khatri A, Siddiqui H, Panda JJ, Rawat BS, Tailor P, Chauhan VS, (2021) Molecular Pharmaceutics, . DOI: 10.1021/acs.molpharmaceut.1c00451

  3. Biofabricated smart-nanosilver: Promising armamentarium for cancer and pathogenic diseases: Jibanananda Mishra, Avneet Kour, Durdana Sadaf Amin, Jiban Jyoti Panda, (2021) Colloid and Interface Science Communications, 44: 100459.

  4. Respiratory delivery of favipiravir-tocilizumab combination through mucoadhesive protein-lipidic nanovesicles: prospective therapeutics against COVID-19: Thakur V, Ratho RK, Panda JJ, (2021) Virusdisease, 32: 1-6. DOI: 10.1007/s13337-021-00679-2

  5. Continuous Flow Fabrication of Fmoc-Cysteine Based Nanobowl Infused Core-Shell Like Microstructures for pH Switchable on Demand Anti-Cancer Drug Delivery: Sonika Chibh, Vibhav Katoch, Avneet Kour, Farheen Khanam, Amit Yadav, Manish Singh, Gopal C Kundu, Bhanu Prakash, Jiban Jyoti Panda, (2021) Biomaterials Science, .

  6. Flow synthesis and in-channel photocatalysis of antimicrobially active ZnS quantum dots using an efficient planar PMMA microreactor: Bhanu Prakash, Astha Singh, Vibhav Katoch, Manju Sharma, Jiban Jyoti Panda, Jadab Sharma and Ashok K Ganguli, (2021) Nano Express, . DOI: https://doi.org/10.1088/2632-959X/abcadf

  7. Recent advances in the fabrication and bio-medical applications of self-assembled dipeptide nanostructures: Chibh S, Mishra J, Kour A, Chauhan VS, Panda JJ, (2021) Nanomedicine, 16: 139-163. DOI: 10.1007/s11356-020-11711-1

  8. Microflow synthesis and enhanced photocatalytic dye degradation performance of antibacterial Bi2O3 nanoparticles: Vibhav Katoch,Nipun Sharma,Manju Sharma,Mayank Baghoria, Jiban Jyoti Panda,Manish Singh, Bhanu Prakash, (2020) Environmental Science and Pollution Research, .

  9. Exposure of calcium carbide induces apoptosis in mammalian fibroblast L929 cells: Indranil De, S Rajesh, Avneet Kour, Henna Wani, Prashant Sharma, Jiban Jyoti Panda, Manish Singh, (2020) Toxicol Mech Methods, 1-22.

  10. Repurposed Drugs, Molecular Vaccines, Immune-Modulators, and Nanotherapeutics to Treat and Prevent COVID-19 Associated with SARS-CoV-2, a Deadly Nanovector: Taru Dube 1, Amrito Ghosh 1, Jibanananda Mishra 2, Uday B Kompella 3, Jiban Jyoti Panda, (2020) Adv Therapeutics, 2000172. DOI: 10.1002/adtp.202000172

  11. Repurposed Drugs, Molecular Vaccines, Immune-Modulators, and Nanotherapeutics to Treat and Prevent COVID-19 Associated with SARS-CoV-2, a Deadly Nanovector: Taru Dube 1, Amrito Ghosh 1, Jibanananda Mishra 2, Uday B Kompella 3, Jiban Jyoti Panda, (2020) Adv Therapeutics, 2000172. DOI: 10.1002/adtp.202000172

  12. l-3, 4-Dihydroxyphenylalanine templated anisotropic gold nano/micro-roses as potential disrupters/inhibitors of α-crystallin protein and its gleaned model peptide aggregates: Avneet Kour; Shikha Sharma; Taru Dube; Anjali Bisht; Manju Sharma; Jibanananda Mishra; Md Ehesan Ali; Jiban Jyoti Panda, (2020) Intl. J. Biol. Macromol., 163: 2374-2391. DOI: 10.1016/j.ijbiomac.2020.09.112

  13. Fluorescent Dopamine-Tryptophan Nanocomposites as Dual-Imaging and Antiaggregation Agents: New Generation of Amyloid Theranostics with Trimeric Effects: Manju Sharma, Virendra Tiwari, Shubha Shukla, Jiban Jyoti Panda, (2020) ACS Appl Mater Interfaces, 20: 44180-44194. DOI: 10.1021/acsami.0c13223

  14. Exploring endolysin loaded alginate-chitosan nanoparticles as future remedy for staphylococcal infections: Jasjeet Kaur, Avneet Kaur,Jiban Jyoti Panda, Kusum Harjai,Sanjay Chhibber, (2020) AAPS Pharm Sci Tech, -: -. DOI: -

  15. Continuous Flow Reactor for the Controlled Synthesis and Inline Photocatalysis of Antibacterial Ag2 S Nanoparticles: Prakash B, Katoch V, Shah A, Sharma M, Devi MM, Panda JJ, Sharma J, Ganguli AK, (2020) Photochem Photobiol., . DOI: 10.1111/php.13297

  16. Effect of Particle Size and Viscosity of Suspensions on Topical Ocular Bioavailability of Budesonide, a Corticosteroid: Vooturi S, Bourne D, Panda JJ, Choi S , Kim H, Yandrapu SK, Kompella UB, (2020) Journal of Ocular Pharmacology and Therapeutics, Journal of Ocular Pharmacology and Therapeutics: .

  17. Comprehensive evaluation of chitosan nanoparticle based phage lysin delivery system; a novel approach to counter S. pneumoniae infections: Gondil VS, Dube T, Panda JJ, Yennamalli RM, Harjai K, Chhibber S, (2020) Int J Pharm., 573: 118850.

  18. Redox-Responsive Dipeptide Nanostructures toward Targeted Cancer Therapy: Chibh S, Kour A, Yadav N, Kumar P, Yadav P, Chauhan VS, Panda JJ, (2020) ACS Omega, 5: 3365-3375.

  19. Nanotheranostics, a future remedy of neurological disorders.: Sharma M, Dube T, Chibh S, Kour A, Mishra J, (2019) Expert Opin Drug Deliv., 16(2): 113-128. DOI: 10.1080/17425247.2019.1562443

  20. Cholesterol bound Plasmodium falciparum co-chaperone 'PFA0660w' complexes with major virulence factor 'PfEMP1' via chaperone 'PfHsp70-x'.Behl A: .Behl A, Kumar V, Bisht A, Panda JJ, Hora R, Mishra PC., (2019) Sci Rep, 9(1): 2664.

  21. Short peptide-based smart targeted cancer nanotherapeutics: a glimmer of hope.: Mishra J, (2019) Ther Deliv, 10(3): 135-138. DOI: 10.4155/tde-2019-0005

  22. Gold Nano-/Micro-Roses on Levodopa Microtubes for SERS-Based Sensing of Gliomas: Taru Dube, Nitin Kumar, Avneet Kour, Jibanananda Mishra, Manish Singh,Bhanu Prakash,Jiban J Panda, (2019) ACS Appl. Nano Mater, 2,5: 2663. DOI: 10.1021/acsanm.9b00155

  23. Carrier-free self-built aspirin nanorods as anti-aggregation agents towards alpha-crystallin-derived peptide aggregates: potential implications in non-invasive cataract therapy: Anjali Bisht, Manju Sharma, Shikha Sharma, Md. Ehesan Ali,Jiban J. Panda, (2019) Journal of Materials Chemistry B, 7: 6945-6954. DOI: 10.1039/C9TB01435G

  24. Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice.: Varshney A, Singh AK, Yadav N, Bihari C, Biswas S, Sarin SK, Chauhan VS., (2018) Hepatology, 67(4): 1392-1407. DOI: 10.1002/hep.29643

  25. Plasmodium falciparum protein 'PfJ23' hosts distinct binding sites for major virulence factor 'PfEMP1' and Maurer's cleft marker 'PfSBP1': .Kaur J, Kumar V, Singh AP, Singh V, Bisht A, Dube T, Behl A, Mishra PC, Hora R., (2018) Pathog Dis., 76(9): . DOI: 10.1093/femspd/fty090

  26. Arginine-α, β-dehydrophenylalanine Dipeptide Nanoparticles for pH-Responsive Drug Delivery.: Singh PK, Chibh S, Dube T, Chauhan VS, (2018) Pharm Res., 35(2): 35. DOI: 10.1007/s11095-017-2299-8

  27. PHISTc protein family members localize to different subcellular organelles and bind Plasmodium falciparum major virulence factor PfEMP-1: Kumar V, Kaur J, Singh AP, Singh V, Bisht A, Mishra PC, Hora R. FEBS J., (2018) 285(2): 294-312. DOI: 10.1111/febs.14340

  28. Receptor Targeted Polymeric Nanostructures Capable of Navigating across the Blood-Brain Barrier for Effective Delivery of Neural Therapeutics.: Dube T, Chibh S, Mishra J, (2017) ACS Chem Neurosci., 8(10): 2105-2117. DOI: 10.1021/acschemneuro.7b00207

  29. Nanoparticles generated from a tryptophan derivative: physical characterization and anti-cancer drug delivery: Dube T, Mandal S, (2017) Amino Acids, 49(5): 975-993. DOI: 10.1007/s00726-017-2403-8.

  30. Efficacy of Dipeptide-Coated Magnetic Nanoparticles in Lung Cancer Models Under Pulsed Electromagnetic Field.: Baskar G, Ravi M, Khatri A, Dev B, Santosham R, Sathiya S, Babu CS, Chauhan VS, Rayala SK, Venkatraman G., (2017) Cancer Invest., 35(6): 431-442. DOI: 10.1080/07357907.2017.1318894

  31. Self-assembled dipeptide-based nanostructures: tiny tots with great applications: Mishra J, (2016) Ther Deliv., 7(2): 59-62. DOI: 10.4155/tde.15.85

  32. Short peptide based nanotubes capable of effective curcumin delivery for treating drug resistant malaria.: Mukherjee TK, Chauhan VS,Alam S, (2016) Nanobiotechnology, 14: 26. DOI: 10.1186/s12951-016-0179-8

  33. Trends in cancer nanomedicine: A.K. Ganguli,A. Shanavas, S. Roy, D. Sharma,S. Karmakar, (2016) Nano Digest, .

  34. Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering.: Chauhan VS, (2014) Polym. Chem., 5: 4418-4436. DOI: 10.1039/C4PY00173G

  35. Antimicrobial activity of cationic peptides in endodontic procedures: Winfred SB, Meiyazagan G,Nagendrababu V, Deivanayagam K, Chauhan VS, (2014) Eur J Dent, 8(2): 254-60. DOI: 10.4103/1305-7456.130626

  36. Dipeptide Nanogels for Anticancer Drug Delivery. In: Proceedings of 82nd Annual symposium of the National academy of sciences India (NASI) on “Nanoscience and Technology for Mankind”: Chauhan VS, (2013) .

  37. Self-assembled nanoparticles based on modified cationic dipeptides and DNA: novel systems for gene delivery.: Varsheney A, Chauhan VS, (2013) Nanobiotechnology, 11(1): 18. DOI: 10.1186/1477-3155-11-18.

  38. Modified dipeptide nanoparticles: vehicles for tumor targeted delivery.: Kaul A, Kumar S, Alam S, Mishra AK, Kundu, GC, Chauhan, VS, (2013) Nanomedicine, 8(12): 1927-1942. DOI: 10.2217/nnm.12.201

  39. Novel dipeptide nanoparticles for effective curcumin delivery.: Alam S, Chauhan VS, (2012) International Journal of Nanomedicine, 7: 4207–4222. DOI: 10.2147/IJN.S33015

  40. Novel dipeptide nanoparticles for effective hydrophobic drug Delivery. Nanoparticle Assembly: VS Chauhan,S Alam, (2011) Fundamentals to Applications, .

  41. Designed peptides as model self-assembling nanosystems: characterization and potential biomedical applications.: Kaul A, Alam S, Babbar AK, Mishra AK, Chauhan VS., (2011) Therapeutic delivery, 2(10): 2839-48. DOI: 10.4155/tde.10.93

  42. Nanoworld of peptide self-assembly. In: souvenir of silver jubilee celebration of Jupiter Biosciences: Chauhan VS, (2010) 37-43.

  43. 3D cell growth and proliferation on a RGD functionalized nanofibrillar hydrogel based on a conformationally restricted residue containing dipeptide.: Dua R, Mishra A, Mittra B, Chauhan VS., (2010) Acs Applied Materials and Interfaces, . DOI: 10.1021/am1005173

  44. Design, Synthesis and Potential Applications of Conformationally Restricted Peptides: VS Chauhan, (2010) Journal of Peptide Science, 16: 199-199.

  45. Stimuli responsive self-assembled hydrogel of a low molecular weight free dipeptide with potential for tunable drug delivery.: Mishra A, Basu A, Chauhan VS, (2008) Biomacromolecules, 9(8): 2244–2250.

  46. Nanovesicles based on self-assembly of conformationally constrained aromatic residue containing amphiphilicdipeptides: Mishra A, Basu A, Chauhan VS., (2008) Langmuir, 24(9): 4571-4576. DOI: 10.1021/la7034533

  47. Selection of salt tolerant plants of Nicotianatabacum L. through in vitro and its biochemical characterization.: Rout GR, Senapati SK, (2008) ActaBiol Hung, 59(1): 77-92.

  48. Nanomed: Nanotechnol: SK Sahoo, S Parveen, (2007) Biol. Med, 3 (1): 20-31.

  49. The present and future of nanotechnology in human health care. Journal of Nanomedicine: Nanotechnology, Biology and Medicine.: Sahoo SK, Parveen S, (2007) 3(1): 20-31.

  50. Fluorescent Dopamine-Tryptophan Nanocomposites as Dual-Imaging and Antiaggregation Agents: New Generation of Amyloid Theranostics with Trimeric Effects: Manju Sharma, Virendra Tiwari, Shubha Shukla, Jiban Jyoti Panda, (0030) ACS Appl Mater Interfaces, 12: 44180-44194. DOI: 10.1021/acsami.0c13223

  1. Nanoworld of peptide self-assembly. In: souvenir of silver jubilee celebration of Jupiter Biosciences Chauhan VS, (2010) 37-43.

  1. Modified dipeptide nanoparticles: vehicles for tumor targeted drug and gene delivery: Panda JJ, (2012) .

  2. Design of low molecular weight dipeptides containing conformationally constraining residue DPhe into stimuli responsive self-assembling hydrogels with potential drug delivery applications: 1735/DEL/2008, (2008) .

  1. Enhanced and effective delivery of microrna by using ligand modified self-assembled cationic dipeptide nanoparticles in hepatocellular carcinoma (HCC),: A Varshney, JJ Panda, AK Singh, SB Rooge, S Biswas, SK Sarin, (2019) Journal of Hepatology, S411: .

  2. Nanoparticles generated from a tryptophan derivative: physical characterization and anticancer drug delivery: Taru Dube, (2017) Crick Nano Science Day,CSIO, Chandigarh., .

  3. Development of Biocompatible Peptide Based Nanostructures Capable Of Traversing the Blood Brain Barrier for Targeting Glioblastoma/Brain Tumors: Crick Nano Science Day,INST, (2016) .

  1. Multimodal Glioblastoma Therapy by Blood Brain Barrier Traversing and Glioma Targeting Anti-cancer Peptide Theranostic Nanoparticles.: at National Institute of Plant Genome Research, New Delhi., (2019) BioCARe Conclave, .

  2. Small Peptide Nanotherapeutics: For Effective Drug Delivery towards various disorders, Multi Omics approaches to Diseases” in the CME Dept. of Experimental Medicine & Biotechnology, PGIMER, Chandigarh., (2019) .

  3. Participated and had oral presentation in ASIA-ARVO: New Delhi, India, (2013) .

Fundings

  • Development of Versatile, Multifunctional and Adaptable Peptide Nanofiber Scaffolds with Potential for Promoting Neuritogenesis in Brain Injury 5, DST
    Funding Amount: 3500000
    PI: Dr. Jiban Jyoti Panda
  • Multimodal Glioblastoma Therapy by Blood Brain Barrier Traversing and Glioma Targeting Anti-cancer Peptide Theranostic Nanoparticles 3, DBT
    Funding Amount: 5200000
    PI: Dr. Jiban Jyoti Panda
  • Glioma Targeting Anticancer Peptide Theranostic Nanoparticles. 3 years, DBT Biocare
    Funding Amount: Rs 52 Lakhs
    Role PI: Dr. Manish Singh Role Co-PI: Dr. Jiban Jyoti Panda

  • 2012

    Ph.D

    Biotechnology (Nanotechnology); International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.

  • 2005

    Master of Science

    BiotechnologyUtkal University, Orissa, India (1 st Division).

  • 2003

    Bachelor of Science

    Chemistry, Zoology, Botany, [Honours]Utkal University, Orissa, India. (1 st Division)

  • Scientist D:Institute of Nano Science and Technology, Phase 10, Sector 64,, Mohali Punjab, India (March 2014 to Present till date )

  • Visiting Research Scholar:Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver,, USA (April 2013 to March 2014 )

  • UNESCO-L?Oreal International Fellow:Skagg’s School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver,, USA (December 2011 to December 2013 )

  • Research Associate:Malaria Research Lab., International Center for Genetic Engineering and Biotechnology (ICGEB), ArunaAsaf Ali Marg, JNU Complex,, New Delhi (December 2010 to December 2011 )

  • Senior Research Fellow:Malaria Research Lab., ICGEB, ArunaAsaf Ali Marg, JNU Complex, New Delhi (August 2008 to July 2010 )

  • Junior Research Fellow:Malaria Research Lab., ICGEB, ArunaAsaf Ali Marg, JNU Complex,, New Delhi (August 2006 to July 2008 )

  • Junior Research Fellow:Laboratory for Nanomedicine, Institute of Life Science, Bhubaneswar,, Orissa, India (December 2005 to May 2006 )

Awards & Honours

  • Har Gobind Khorana Young Innovative Biotechnologist Award, 2021

  • ICMR-DHR International Fellowship for Biomedical Scientists-2019

  • Best Poster Award, DBT-BIOCARE conclave 2019.
  • Best poster at Indian International Science Festival (IISF) 2017 held in Chennai during 13-16 October, 2017.
  • Best Free Paper Presentation Award, ASIA ARVO 2013, New Delhi.
  • American Association of Pharmaceutical Scientist (AAPS) Graduate Student Symposium Award in Formulation Design and Development, 2011.
  • Organization of Pharmaceutical Producers of India (OPPI) Young Scientist Award 2011.
  • The UNESCO-L’OREAL International Fellowship 2011 for Young Women in Life Sciences
  • Best poster award’ in FCS, 2011, ICGEB, New Delhi, India.
  • Received ‘Best poster award’ in NCMB 2009, at CCMB, Hyderabad.
  • Received ‘Budding Nanotechnologist award’ in ‘2nd Winter School of Nanotechnology 2009’, organized at NIPER, Chandigarh.
  • Awarded CSIR-NET, ICMR and DBT Junior Research Fellowships.
  • Awarded Certificate of Merit for reasons of outstanding academic performance and being among the top 0.1% of successful candidates of AISSCE 2000 in Biology.
  • Awarded Certificate of Merit for reasons of outstanding academic performance and being among the top 0.1% of successful candidates of AISSE 1998 in Mathematics.
  • National Merit Scholarship for outstanding performance in AISSCE 2000 by CBSE.
  • National Merit Scholarship for outstanding performance in AISSE 1998 by CBSE.

Professional Recognitions

  • Member of American Association of Pharmaceutical Scientists.
  • Member of American Chemical Society.
  • Associate Member of American Association for Cancer Research.
  • Reviewer for the journal ‘Pharmaceutical Research’.
  • Reviewer for the Journal of Ocular Pharmacology and Therapeutics.
  • Reviewer for the journal ‘Therapeutic Delivery’.

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