Associate Professor (Scientist-E), Adjunct Faculty of IISER Mohali and AcSIR
New synthetic methods, Functional organic materials, Supramolecular chemistry, Polymer chemistry. The research in my group is centred on synthetic organic chemistry with a view to exploring nanoporous and nanomaterials for various types of applications ranging from energy, catalysis, sensing, and Nanotherapeutics. Thus, it is highly interdisciplinary in nature. The general strategy of our research is designing and synthesizing the functional nanomaterials with targeted applications and understanding the properties by applying state-of-the-art characterization techniques.
• Synthetic Methodology • Sensing • Bio-imaging • Opto-electronic applications • White-light emission • As Photosensitizer in Catalysis
• Organic Transformation Reactions • Biomass conversion • Photocatalysis • Dye/pollutant degradation
• Drug Delivery (Cancer therapy) • Pesticide Delivery (Agriculture) • Anti-microbial coating (Healthcare)
At the Institute of Nano Science and Technology (INST), Mohali, our scientific research focuses on the investigation and understanding of the basics of Science (Nano). The lessons learned from this exploration are being applied to technology development to positively impact health and well-being around the world.
In the short span of 7 years, in addition to being able to publish papers in internationally reputed journals, we have developed 5 technologies, out of which two technologies have shown promising for technology transfer to industries (shown interests and under discussion) and one start-up company being registered.
The research area of Dr Jayamurugan and his group focuses on three areas related to Energy, Environment and Health using functional organic nanomaterials.
Motivation: Today, the biggest problem faced by the earth is global warming due to the use of non-sustainable energy sources. This leads to pollution in various forms, however, pollution related to fuels and coal (automobiles and industries) can be conquered by the use of electricity generated through sustainable energy sources (Solar and other sustainable processes). However, in contrast, these technologies cannot solve pollution arising from organic industrial effluents such as pharmaceuticals, dyes, pesticides, etc. That is why it is imperative to find alternative solutions. Upon request from a pharmaceutical company, we have developed a process that can achieve complete recovery of soluble para amino phenol from the mother liquor which has significant economical values (patent filing under process). Several features make this affordable process self-sustainable, zero-waste, and environmentally friendly. A solution to this problem would not only save the environment but also all living systems on the planet.
Nanocatalysis: To substantiate further this objective, we also developed a sonocatalyst which degrades dyes in an aqueous solution at room temperature without using any light. This was achieved by realizing the synergistic effect of biomass-derived carbon dots polymer-supported Pd nanoparticles in dark (ACS Omega 2020, 5, 22603).
In addition, we contribute to the sustainable energy crisis by expanding the use of natural biodegradable polymers such as cellulose and starch. Due to their abundant availability on earth, they have drawn increasing attention as an alternative indirect energy source to crude oil. To do so, two different approaches have been used - the chemo-processing method and the degradation route. Our objective is to combine both methods depending on the nature of the problems. The chemo-processing method utilizes the inherent energy of biomass for the synthesis of metal oxide nanoparticle-based nanocomposites using suitable organic functionalization and metal salts. Thus, using the chemo-processing approach, abundant cellulose with thiol modification was used to generate highly reactive copper-oxide (CuI/IIO) NPs-based low-cost catalyst effective for azide-alkyne cycloaddition (CuAAC) (Asian J. Org. Chem. 2021, 10, 3428) and Glaser and cross Glaser-coupling processes using the chemo-processing approach (Chem. Commun. 2020, 56, 2582). The newly designed catalyst has been observed to ensure its usage in the industrial environmental-friendly synthesis of rufinamide drug intermediate (a drug for the treatment of epilepsy).
Whereas, the biomass degradation pathways have been successfully explored using carbon dots (CDs) derived from biomass (citric acid) and were used as a solid Brønsted acid catalyst, i.e., p-toluenesulfonic acid as a simple, low-cost benchtop chemical precursor to convert glucose to 5-HMF. Further, the robustness of the Brønsted acid catalyst was demonstrated in another application, i.e., acid-catalyzed esterification of levulinic acid (LA) to alkyl levulinate as a fuel additive (ChemistrySelect, 2022, 7, e202104448) under greener conditions. By designing the dual (Lewis and Bronsted acid) functionality subtle change in solvent system selective furfural formation was achieved from biomass-derived glucose (Biomass Conver. Biorefin. 2022, DOI: 10.1007/s13399-022-03182-w). Currently, we are exploring other biomass sources to utilize them as nanocomposite as sustainable catalysts (to be communicated).
Research Area II: Push-pull chromophores-based FOM for Diverse Applications: Strong push-pull chromophores (TCBDs) obtained by [2+2] cycloaddition-retroelectrocyclization reactions are generally non-luminescent and limit their applications in bio-imaging and sensing area. The development of luminescent 1,1,4,4-tetracyanobuta-1,3-diens (TCBDs) is an active research area, with a quantum yield (F) of 7.8% achieved so far in cyclohexane by appending fluorophore. Whereas, we have initiated this field by turning non-emissive chromophores into emissive just by using urea with unique electron-donating ability as a donor, J. Org. Chem. 2019, 84, 8941) and nanotechnology-based approaches (under review). Our novel method radically reforms a weakly emissive 2,3-disubstituted TCBD (phenyl-TCBD 1) (FF = 2.3% in CH3CN) into a water-soluble, biocompatible nanoformulation as highly emissive aggregates 1NPsÌPF-127 with FF = 7.9% in H2O that too without fluorophore conjugation. The developed urea functionalized TCBD with a subtle change in substituent has enabled us to demonstrate the fluoride (J. Photochem. Photobiol. A, 2021, 410, 113613) detection in water. To date, few fluoride sensors provide both colorimetric and fluorometric detection (Indian Patent No. 202011028595). Our solution to this problem would significantly contribute to the human population around the globe, especially in remote areas affected by fluorosis diseases. Our research further aims to change the molecular property to obtain WLE (white light-emission) using supramolecular chemistry and nanotechnology (Langmuir 2022, 38, 430).
Organic solvents limit [2+2] CA–RE reaction in biological fields. We examined the formation of TCBDs through CA–RE reactions and their unusual reactivity to produce N-heterocyclic compounds when surfactant nature and concentrations were varied in the aqueous phase (Org. Biomol. Chem. 2023 DOI: 10.1039/D3OB00053B). Unlike organic solvent-mediated CA–RE reactions, the present nanoreactor-mediated approach enabled the selective production of TCBDs as well as cardiotonic drugs resembling new heterocycles using H2O as a green solvent. Thus opening a window for exploring potential new drug molecules. Besides the widely explored organic electronics/materials, we believe that this study would help overcome the long-standing limitation of CA–RE reaction applicability in biological fields. One such example we showed recently was that to counter the harmful effects of excess nitric oxide (NO) through its inactivation, we developed urea-functionalized push-pull chromophores having TCBD/TCNQ as acceptor moieties. The inhibition of neovascularization in a corneal injury model suggested that Urea-TCNQ was effective in preventing pathological conditions (in collaboration with biology expert Prof. Deepa Ghosh, INST; manuscript under revision).
Our research on optoelectronic materials not only opened up a new research area, i.e., luminescent TCBDs-based push-pull chromophores and CA-RE reactions in water for the biological field, but they also resulted in a first test-strip kit for naked eye quantification of fluoride ion in water. Currently, there is no test-strip kit available for this to avoid fluorosis.
Research Area III: Polymeric Nanoformulation for Health and agricultural applications: WHO estimates that cancer is the second leading cause of death in the world and that it killed 9.6 million people in 2018 alone. So addressing/improving chemotherapy using nanotechnology is a sizeable achievement. The design and synthesis of tailor-made polymeric and hybrid nanomaterials were studied in vitro for their effects on anti-cancer drug uptake and release (LCS-1 and niclosamide) induced by magnetic hyperthermia. (ACS Biomater. Sci. Eng. 2022, 8, 2636; ACS Biomater. Sci. Eng. 2022, 8, 2088; ACS Biomater. Sci. Eng. 2020, 5, 1102; Biomacromolecules 2018, 19, 803). In-vivo biological studies were conducted in collaboration with an in-house biology expert (Dr. Rehan Khan, INST). As part of another study, we demonstrated how to construct core-shell nanocarriers that contain denser hydrophobic cores through a combination of supramolecular and covalent interactions. These nanocarriers demonstrated enhanced drug uptake and sustained release capabilities (Langmuir 2022, 38, 8999) in comparison to their conventional micelle-based approach. Further, in health, a new type of polymeric biocide wherein 100% drug units were developed for antimicrobials coating of sutures (ACS Appl. Polym. Mater. 2022, 4, 3952) Highlighted in the Front cover of the Journal). Also, developed stimuli-responsive drug delivery systems for cancer therapeutic applications (under review in ACS Appl. Nano. Mater.).
Nanotechnology-mediated pesticide delivery using natural polymers is being actively explored to overcome conventional pesticide release limitations. Our study is motivated by the lack of current information on what are the benefits and disadvantages of using hybrid nanoparticles (NP) and which polysaccharides are suitable concerning pesticide loading efficiency (PLE wt%), entrapment efficiency, and sustained pesticide release (SPR %). We systematically designed, synthesized, and characterized the hybrid- and organic-NCs with various polysaccharides to discern the role of inorganic support used in the hybrid-NCs, the type of nanomaterials synthesis such as hybrid versus organic systems and to understand the beneficial effect of functionalization of natural polysaccharide (cellulose) to uncover answers to these questions (Nanotechnology 2021, 32, 475704)
Technologies developed are
1 First test-strip kit for naked-eye quantification of fluoride ion in water: We successfully demonstrated a new class of push-pull chromophores which can selectively sense fluorine anion in drinking water by naked-eye paper-based colorimetric detection without the need for any equipment (Indian Patent No. 202011028595). India Science TV Channel has reported a news coverage (documentary) on our technology related to equipment-free, instant paper-strip based Fluoride detection in water (news coverage: https://www.indiascience.in/videos/anusandhanika-episode-6-h). A startup company is being registered.
2 Biomass-based sun-screen (SS) lotion: to overcome the limitation of small molecules and metal-oxide nanoparticles-based SS lotion, a new approach is adopted to develop biomass-based highly stable, biocompatible sun-protective cream. Currently, the final formulation is being tested for microbial stability study and a start-up company (massbiocare) is being registered as one of the co-founders. For this start-up pitch, Dr Gowri (as Post-doc) has received the best pitching award with a cash prize organized by Chandigarh Angels Network and Punjab state council science and technology (PSCST). (news coverage: https://www.tribuneindia.com/news/chandigarh/tricity-businesswomen-shine-at-startup-summit-455120
3 Tiny contribution towards low-cost drugs: The developed polymer-supported copper oxide nanoparticles catalyst and its applications in C-C and C-N bond-forming reactions have been successfully demonstrated with its use in Rufinamide drug industrial synthesis to bring down the cost. The rufinamide drug is an anti-convulsant and required to take the daily course for a lifetime, which puts the patient in to highly bothersome. (Indian Patent no. 201911042361). Also, future studies are directed towards other triazole drug molecules (Asian J. Org. Chem. 2021). (news coverage: https://dst.gov.in/inst-develops-nanotechnology-based-low-cost-method-production-antiepileptic-drug-rufinamide), Currently, a Bangalore based company is testing our catalyst for their industrial use to perform click reactions.
4 Solution for industry Effluent contamination: This technology was developed upon request from a Gujarat-based pharmaceutical company. One of the major contributors to environmental pollution is the pharmaceutical and chemical industries' effluent contamination in environmental water bodies. Developed a simple solution for recovering the slats and unreacted chemicals in a self-sustainable fashion. Though the invented technology is optimized for paracetamol industries, future development of optimization for specific industries can be fine-tuned to reach the vast number of other organic industries, to achieve zero waste sustainable process with revenue generating and environmental safety (patent filing under process).
5 Antimicrobial coating for Sutures: New type of polymeric biocide (100% drug units and having no spacer) was developed for antimicrobials coating of sutures (ACS Appl. Polym. Mater. 2022 Highlighted in the Front cover of the Journal; ACS Appl. Nano. Mater. Under review). Currently, we are in talks with an Israel-based company for developing an antimicrobial coating for surgical devices.
Chemical Industries convert raw materials into useful products that we use in daily life. This has brought a tremendous change in how the world operates. It is of utmost important for everyone to understand the importance of the chemical industries which have touched all our facets of life like Agriculture, Health, Environment, Food, Hygiene, Transportation, Decor, etc. Unfortunately, this also brings harmful effects such as pollution due to industrial waste contamination. As a chemist, while creating new advanced nanomaterials for making mankind and other living system betterment, We strongly believe that through our research even this negative effect can be tackled.
Biomass-based sun-screen (SS) lotion: News coverage: https://www.tribuneindia.com/news/chandigarh/tricity-businesswomen-shine-at-startup-summit-455120
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1.Enhancing Photophysical and Photosensitizing Properties of Nanoaggregates of Weakly Emissive Non-Planar Push-Pull Chromophore , Arif Hassan Dar ,Anas Ahmad ,Ajay Kumar ,Vijayendran Gowri ,Chandrashekhar Jori ,Shaifali Sartaliya ,Neethu K M ,Rehan Khan ,Govindasamy Jayamurugan , Chemrxiv (preprint) , 2023 , 10.26434/chemrxiv-2023-d5w1t
2.A Study of [2+2] Cycloaddition–Retroelectrocyclization in Water: Observation of Substrate-driven Transient Nanoreactor Induced New Reactivity , Neethu, k. M.; Kritika, N.; Dar, A. H.; Bajaj, A.; Gopal, S. A.; Gowri, V.; Mithilesh, N.; Sartaliya, S.; Sharma, R.; Solanki, A. K.; Ali, M. E.; Muthukrishnan, A.; Jayamurugan, G.* , Organic and Biomolecular chemistry , 2023 , https://doi.org/10.1039/D3OB00053B
3.Efficient Nitric Oxide Scavenging by Urea-Functionalized Push-Pull Chromophore Modulates NO-Mediated Diseases , Roy, H. S.; Neethu, K. M.; Rajput, S.; Sadhukhan, S.; Gowri, V.; Dar, A. H.; Monga, M.; Salaria, N.; Guha, R.; Chattopadhyay, N.; Jayamurugan G , Chem. Eur. J. , 2023 , 10.1002/chem.202301748
4.Perspectives on dual-purpose functional nanomaterials for detecting and removing fluoride ion from environmental water , Dhiman, S.; Solanki, A. K.; Nag, K.; Jayamurugan, G , ChemNanoMat , 2023 , 10.1002/cnma.202300369
5.Biocidal polymer derived near white light-emitting carbonized polymeric dots for antibacterial and bioimaging applications. , Sartaliya, S.; Sharma, R.; Sharma, A.; Chopra, V.; Ghosh, D.; Jayamurugan, G.* , Chemrxiv (preprint) , 2023 , https://10.26434/chemrxiv-2023-bjcxb
6.Superior Photophysical and Photosensitizing Properties of Nanoaggregates of Weakly Emissive Dyes for Use in Bioimaging and Photodynamic Therapy , Arif Hassan Dar, Anas Ahmad, Ajay Kumar, Vijayendran Gowri, Chandrashekhar Jori, Shaifali Sartaliya, Neethu K. M, Nemat Ali, Mahendra Bishnoi, Rehan Khan*, and Govindasamy Jayamurugan** , Biomacromolecules , 2023 , https://doi.org/10.1021/acs.biomac.3c00892
7.New Water-Soluble Magnetic Field-Induced Drug Delivery System Obtained Via Preferential Molecular Marriage over Narcissistic Self-Sorting: , Shaifali Sartaliya, Ritu Mahajan, Raina Sharma, Arif Hassan Dar, Govindasamy Jayamurugan , (2022) , Langmuir , 10.1021/acs.langmuir.2c01403
8.Realizing Direct Conversion of Glucose to Furfurals with Tunable Selectivity Utilizing a Carbon Dot Catalyst with Dual Acids Controlled by a Biphasic Medium , Sharma, R.; Selim, A.; Devi, B.; Murugan, S. M.; Sartaliya, S.; Elumalai, S. , (2022) , Biomass Conversion and Biorefinery , 10.1007/s13399-022-03182-w
9.Sulphonated Carbon Dots Synthesized Through a One-Pot, Facile and Scalable Protocol Facilitates the Preparation of Renewable Precursors Using Glucose/Levulinic Acid , Selim, A.; Sharma, R.; Arumugam, S. M.; Elumalai, S. , (2022) , 7: e202104448 , Chemistryselect , 10.1002/slct.202104448
10.Cellulose-Conjugated Copper-Oxide Nanoparticles for the Treatment of Ethanol-Induced Gastric Ulcers in Wistar Rats , Kumar, A.; Selim, A.; Gowri, V.; Ahmad, A.; Vyawahare, A.; Nadim, A.; Siddiqui, Raza, S. S. , (2022) , ACS Biomaterials Science & Engineering , 10.1021/acsbiomaterials.2c00090
11.Thiol-Functionalized Cellulose-Grafted Copper Oxide Nanoparticles for the Therapy of Experimental Colitis in Swiss Albino Mice , Rakesh Kumar Mishra, Abdul Selim, Vijayendran Gowri, Anas Ahmad, Ahmed Nadeem, Nahid Siddiqui, Syed Shadab Raza , (2022) , 8: 2088-2095 , ACS Biomaterials Science & Engineering , 10.1021/acsbiomaterials.2c00124
12.Unravelling the effect of non-drug spacers on a true drug-polymer and a comparative study of their antimicrobial activity , S. Sartaliya, V. Gowri, V. Chopra, H. S. Roy, D. Ghosh, G. Jayamurugan,* , (2022) , ACS Applied Polymer Materials , 10.1021/acsapm.2c00413
13.Nanotechnology-Assisted, Single-Chromophore-Based White-Light-Emitting Organic Materials with Bioimaging Properties , Arif Hassan Dar, Vijayendran Gowri, Rakesh Kumar Mishra, Rehan Khan, Govindasamy Jayamurugan* , (2021) , 38: 430-438 , Langmuir , 10.1021/acs.langmuir.1c02797
14.Thiol-Functionalized Cellulose Wrapped Copperoxide as a Green Nano Catalyst for Regiospecific Azide–Alkyne Cycloaddition Reaction: Application in Rufinamide Synthesis , A. Selim, K. M. Neethu, V. Gowri, S. Sartaliya, S. Kaur,G. Jayamurugan* , (2021) , 10.: 3428-3433 , Asian J. Org. Chem. , 10.1002/ajoc.202100658
15.A systematic study to unravel the potential of using polysaccharides based organic-nanoparticles versus hybrid-nanoparticles for pesticide delivery , R. Mahajan; A. Selim, K. M, Neethu, S. Sharma, V. Shanmugam, G. Jayamurugan,* , (2021) , 32: 475704 , Nanotechnology , 10.1088/1361-6528/ac1bdc
16.A subtle change in substituent enabled multi-ways fluorine anion signals including paper-strip colorimetric detection using urea-functionalized push–pull chromophore receptor , Vijayendran Gowri, Sachin Jalwal, Arif Hassan Dar, Arya Gopal, Azhagumuthu Muthukrishnan, Ashima Bajaj, Md. Ehesan Ali, Govindasamy Jayamurugan* , (2021) , 410: 113163 , Journal of Photochemistry and Photobiology A: Chemistry , 10.1016/j.jphotochem.2021.113163
17.Tuning of the Cross-Glaser Products mediated by Substrate-Catalyst’s Polymeric Backbone Interactions , S. Kuar, A. Mukhopadhyaya, A. Selim, V. Gowri, K. M. Neethu, A. H. Dar, S. Sartaliya, M. E. Ali*, G. Jayamurugan* , (2020) , 56: 2582-2585 , Chem. Commun. , 10.1039/C9CC08565C
18.Effect of galvanotaxic graphene oxide on chloroplast activity: Interaction quantified with Biolayer-Interferometry coupled confocal microscopy , Sharma S., Sahu B.K., Srinivasan S., Singh M., G. Jayamurugan., Vijayakumar S.* , (2020) , 162: 147-156 , Carbon , 10.1016/j.carbon.2020.02.054
19.Synthesis of 1,1,4,4‐Tetracyanobuta‐1,3‐Dienes using Tetracyanoethylene Oxide via [3+2]‐Cycloaddition‐Ring Opening Reaction , A. H. Dar, V. Gowri, K. M. Neethu, G. Jayamurugan* , (2020) , 5: 12437-12441 , ChemistrySelect , 10.1002/slct.202003179
20.Synergistic Effects of Carbon Dots and Palladium Nanoparticles Enhance the Sonocatalytic Performance for Rhodamine B Degradation in the Absence of Light , Abdul Selim, Sharanjeet Kaur, Arif Hassan Dar, Shaifali Sartaliya, and Govindasamy Jayamurugan* , (2020) , 56: 22603-22613 , ACS Omega , 10.1021/acsomega.0c03312
21.Comparative Acute Intravenous Toxicity Study of Triple Polymer Layered Magnetic Nanoparticles with Bare Magnetic Nanoparticles in Swiss Albino Mice , Anas Ahmad, Md. Meraj Ansari, Ajay Kumar, Akshay Vyawahare, Rakesh Kumar Mishra, Govindasamy Jayamurugan, Syed Shadab Raza, Rehan Khan* , (2020) , 14: 1362-1380 , Nanotoxicology , 10.1080/17435390.2020.1829144
22.Designing of Push-Pull Chromophores with Tunable Electronic and Luminescent Properties using Urea as Electron Donor , A. H. Dar, V. Gowri, A. Gopal, A. Muthukrishnan, A. Bajaj, S. Sartaliya, A. Selim, M. E. Ali, G. Jayamurugan* , (2019) , 84: 8941 - 8947 , The Journal of Organic Chemistry , 10.1021/acs.joc.9b00841
23.Hyperbranched polymer-functionalized magnetic nanoparticles mediated hyperthermia and niclosamide bimodal therapy of Colorectal Cancer Cells. , A Ahmad, A Gupta, MM Ansari, A Vyawahare, G Jayamurugan*, R. Khan* , (2019) , 6: 1102-1111 , ACS Biomater. Sci. Eng. , 10.1021/acsbiomaterials.9b01947
24.Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells , A. Gupta, A. AHMAD, H. Singh, S. Kaur, Neethu K M, M. M. Ansari, G. Jayamurugan*, R. Khan* , (2018) , 19: 803-815 , Biomacromolecules , 10.1021/acs.biomac.7b01607
25.Design and Synthesis of Aviram–Ratner-Type Dyads and Rectification Studies in Langmuir–Blodgett (LB) Films , G. Jayamurugan, V. Gowri, D. Hernández, S. Martin, A. González-Orive, C. Dengiz, O. Dumele, F. Pérez-Murano, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, B. Breiten, A. D. Finke, G. Jeschke, B. Bernet, L. Ruhlmann, P. Cea, F. Diederich , (2016) , 22: 10539-10547 , Chem. Eur. J. , 10.1002/chem.201505216
26.Size and Energy Level Tuning of Quantum Dot Solids via a Hybrid Ligand Complex , M. L. Böhm, T. C. Jellicoe, J. P. H. Rivett, A. Sadhanala, N. J. L. K. Davis, F. S. F. Morgenstern, K. C. Gödel, G. Jayamurugan, C. G. M. Benson, N. C. Greenham, B. Ehrler , (2015) , 6: 3510−3514 , J. Phys. Chem. Lett. , 10.1021/acs.jpclett.5b01751
27.Selective endo and exo binding of mono- and ditopic-ligands to a rhomboidal diporphyrin prism , G. Jayamurugan, D. A. Roberts, T. K. Ronson, J. R. Nitschke , (2015) , 54: 7539-7543 , Angew. Chem. Int. Ed. , 10.1002/anie.201501359
28.One-Pot access to push-pull oligoenes by sequential [2+2] cycloaddition–retroelectrocyclization reactions , G. Jayamurugan, A. D. Finke, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, F. Diederich , (2014) , 79: 426–431 , J. Org. Chem , 10.1021/jo402440m
29.Enhancement of immunogenicity and efficacy of a plasmid DNA rabies vaccine by nanoformulation with a fourth-generation amine-terminated poly(ether imine) dendrimer , P. T. Ullas, S. N. Madhusudana, A. Desai, G. Jayamurugan, N. Jayaraman , (2014) , 9: 627–634 , Int. J. Nanomedicine , 10.2147/IJN.S53415
30.Expanding the chemical structure space of optoelectronic molecular materials: unprecedented push–pull chromophores by reaction of a donor-substituted tetracyanofulvene with electron-rich alky , G. Jayamurugan, O. Dumele, J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, B. Bernet, F. Diederich , (2013) , 135: 3599–3606. , J. Am. Chem. Soc. , 10.1021/ja312084s
31.Photophysical behavior of poly(propyl ether imine) dendrimer in the presence of nitroaromatic compounds , R. S. Bagul, Y. B. R. D. Rajesh, G. Jayamurugan, A. Bera, A. K. Sood, N. Jayaraman , (2013) , A, 253: 1–6 , J. Photochem. Photobiol. , 10.1016/j.jphotochem.2012.12.011
32.6,6-Dicyanopentafulvenes: Electronic structure and regioselectivity in [2 + 2] cycloaddition–retroelectrocyclization reactions , A. D. Finke, O. Dumele, M. Zalibera, D. Confortin, P. Cias, G. Jayamurugan,J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, G. Gescheidt, F. Diederich , (2012) , 134: 18139–18146 , J. Am. Chem. Soc , 10.1021/ja309141r
33.Expanding the chemical space for push-pull chromophores by non-concerted [2+2] and [4+2] cycloadditions: access to a highly functionalized 6,6-dicyanofulvene with an intense low-energy charge , G. Jayamurugan, J.-P. Gisselbrecht, C. Boudon, F. Schoenebeck, W. B. Schweizer, B. Bernet, F. Diederich , (2011) , 47: 4520–4522 , Chem. Commun. , 10.1039/C1CC10247H
34.Dendritic poly(ether imine) based gene delivery vector , U. P. Thankappan, S. N. Madhusudana, A. Desai, G. Jayamurugan, Y. B. R. D. Rajesh, N. Jayaraman , Bioconjugate Chem , (2011) , 22 , 115–119 , 10.1021/bc1003108
35.Interaction of single-walled carbon nanotubes with poly(propyl ether imine) dendrimers , G. Jayamurugan, K. S. Vasu, Y. B. R. D. Rajesh, S. Kumar, V. Vasumathi, P. K. Maiti, A. K. Sood, N. Jayaraman , J. Chem. Phys. , (2011) , 134 , 104507/1–104507/6 , 10.1063/1.3561308
36.Increased efficacies of an individual catalytic site in clustered multivalent dendritic catalysts , G. Jayamurugan, N. Jayaraman , Adv. Synth. Catal. , (2009) , 351 , 2379–2390 , 10.1002/adsc.200900377
37.Preparation and catalytic studies of palladium nanoparticles stabilized by a dendritic ligand-functionalized Silica , G. Jayamurugan, C. P. Umesh, N. Jayaraman , J. Mol. Catal. A: Chem , (2009) , 307 , 142–148 , 10.1016/j.molcata.2009.03.020
38.Inherent photoluminescence properties of poly(propyl ether imine) dendrimers , G. Jayamurugan, C. P. Umesh, N. Jayaraman , Org. Lett. , (2008) , 10 , 9–12 , 10.1021/ol702635w
39.Structure of poly(propyl ether imine) dendrimer from fully atomistic molecular dynamics simulation and by small angle X-ray scattering , C. Jana, G. Jayamurugan, R. Ganapathy, P. K. Maiti, N. Jayaraman, A. K. Sood,C. Jana , (2006) , 124: 204719/1–204719/10 , J. Chem. Phys. , 10.1063/1.2194538
40.Synthesis of large generation poly(propyl ether imine) (PETIM) dendrimers , G. Jayamurugan, N. Jayaraman , Tetrahedron , (2006) , 62 , Tetrahedron, 9582–9588 , 10.1016/j.tet.2006.07.094
1.Dendrimer-metal nanocomposites and their optical behavior: In Nanotechnological Applications of Novel polymers; Adeli, M., Ed.; Transworld Research Network: Trivandrum , B. M. Kiran,N. Jayaraman , (2009) , 105–131
1.Applying synthetic lethality to nanomedicine: LCS-1 loaded magnetite and polymeric nanoparticles for the treatment of BLM and CHEK2-deficient colorectal cancer cells: In CANCER MEDICINE 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY , A. Gupta, Ahmad A , (2018) , 7: 27-28
2.CuI/IIO Nanoparticles-Grafted Tailor-made Cellulose as an Efficient Catalyst for “Glaser” Homo- and Hetero-coupling Reactions “First INST-CeNS Joint symposium , Hampi , (2017)
3.Customized Nanocarrier for Therapeutic Targeting of Cancer Cells, DBT workshop for biotechnology school , organized by INST at NABI , (2017)
4.Biocompatible hyperbranched polymers coated magnetite nanocarrier for therapeutic targeting of cancer cells National Conference on Trends in Nanobiotechnology (NCTN-2016): CCS Haryana Agricultural University, Hisar , India , (2016)
5.Fulvenoid, nonplanar push-pull chromophores: Poster presentation at the Electronic Process in Organic Materials Gordon Conference, Lucca, Italy , J.-P. Gisselbrecht, C. Boudon, W. B. Schweizer, F. Diederich,A. D. Finke, O. Dumele , (2012)
6.Wisenshaftforumchemie: Expanding the Chemical Space for Push-Pull chromophores by Non-concerted [2+2] and [4+2] Cycloadditions: Access to a Highly Functionalized 6,6-dicyanopentafulvene with Attractive Opto-electronic Properties , F. Schoenebeck, W. B. Schweizer, B. Bernet, J.-P. Gisselbrecht, C. Boudon, F. Diederich , (2011)
7.Swiss Chemical Society: ETH-Zurich / Switzerland _ Poster: “Diverse Chemical Reactivity of Push-Pull type Fulvene with Electron Rich Alkynes , O. Dumele, W. B. Schweizer, B. Bernet, J.-P. Gisselbrecht, C. Boudon, F. Diederich , (2011)
8.3rd EuCheMS Chemistry Congress: Nürnberg / Germany _ Poster: “Synthesis and Studies of Chiral and Achiral Push-Pull Type Charge-Transfer Chromophores Derived from Different Oligoyne , B. B. Frank, M. Kivala, W. B. Schweizer, B. C. Blanco, B. Breiten, R. R. Tykwinski, E. Jahnke, C. Boudon, J.-P. Gisselbrecht, F. Diederich , (2010)
9.Synthesis and Studies of Poly(Ether Imine) (PETIM) Dendritic Macromolecules: National Conference on Chemistry,Bangalore University, Bangalore, India. , N. Jayaraman , (2006)
10.International Symposium in Organic Chemistry: IISc, Bangalore, India _ Poster Presentation: “Synthesis and Fluorescence Studies of Poly(Propyl Ether Imine) (PETIM) Dendrimers , N. Jayaraman , (2005)
Ramanujan Fellowship awarded by DST-SERB-five year research grant (2016-2021)
Early Career Research (ECR) Award by SERB-three year research grant (2016-2019)
Two and half year’s post-doctoral fellowship sponsored by EPSRC at University of Cambridge.(2012)
Three years post-doctoral fellowship sponsored by European Research Council (ERC) at ETH-Zurich.(2010)
Awarded Senior Research Fellowship (SRF) by Council of Scientific Industrial Research.(2005)
Secured second place in State level inter collegiate P. G. quiz competition.(2003)
Qualified in national eligibility test “CSIR-NET-2003”. Awarded Junior Research Fellowship (JRF) by Council of Scientific Industrial Research.
Secured 95.5 percentile in national level Graduate Aptitude Test in Engineering “GATE-2002”
Research Associate: Indian Institute of Science, (PI: Prof. N. Jayaraman), Bangalore, India (April 2009 to December 2009 )
Postdoctoral Fellow: ETH-Zurich, . (PI: Prof. François Diederich), Switzerland (January 2010 to December 2012 )
Associate Professor (Scientist-E): Institute of Nano Science and Technology, Mohali, India (January 2020 to Present till date
Postdoctoral Research Associate: University of Cambridge,, United Kingdom. (January 2013 to May 2015 )
Assistant Professor (Scientist-D): Institute of Nano Science and Technology,, Mohali, India (June 2015 to December 2019 )
Title: Dual-Drug loaded Customized Nanocarrier for Synergistic Synthetic Lethal killing of colorectal Cancer (As Co-PI)
PI: Dr. Jayamurugan Govindasamy
Funding Amount: 19 Lakhs
Funding Agency: DST-Nanomission
Title: Design , Synthesis and Applications of Functional Organic Nanomaterials
PI: Dr. Jayamurugan Govindasamy
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Tenure: 5 years
Funding Agency: DST-SERB (Ramanujan Fellowship)
Title: Synthesis of a New Class of Strong Organic Acceptors and their Nanoparticles Formulation for Sensing Application
PI: Dr. Jayamurugan Govindasamy
Funding Amount: 24.14 Lakhs
Tenure: 3.5 years
Funding Agency: DST-SERB-ECR
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PI: Dr. Jayamurugan Govindasamy
Funding Amount: 76.4 Lakhs
Tenure: 3 years
Funding Agency: DBT
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PI: Dr. Jayamurugan Govindasamy
Funding Amount: 47.5 Lakhs
Tenure: 3 years
Funding Agency: DST-SERB-CRG