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Faculty Directory

Dr. Deepika Sharma

Scientist-D

Currently working as a Scientist D at the Institute of Nano Science and Technology (INST), Mohali (Department of Science and Technology, Government of India).My Lab research interest lies at the interface of engineering, medicine and biology to develop novel platforms for understanding, diagnosing and treating human disease. Specifically, our work is focused on diagnostics and treatments for cancer. The research work is centered on designing and development of targeted nanoparticles to perform a complex task such as multimodal, non-invasive tumor imaging; trigger the release of a targeted, therapeutic payload, hyperthermia and multifunctional agents for cancer therapies. I am also a member of the Indian Association For Cancer Research (IACR), Indian Association for Hyperthermic Oncology and Medicine (IAHOM) and Biotech Research Society of India (BRSI).

CONTACT INFORMATION :

Research Interest

  • Dr. Sharma’s present research interest focuses on the use of heat in the treatment of cancer and making efforts in establishing hyperthermia as an independent therapy system to treat cancerous cells. Her Lab mission is to accelerate the study of cancer therapy through developing a broad range of impactful nanosystems that can be used to detect, monitor, or enhance cancer treatment. Area of particular focus is hyperthermia and its contribution towards cancer prevention. Her multidisciplinary team is also working on the downstream processing of natural anticancer bioactives, mimicking tumor microenvironment through biochips and the role as well as risks of other barrier contributing to cancer treatment.

Research Highlights

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PhD Students

  • MS. RITU SHARMA

    Email: ritu.ph22207@inst.ac.in

    Reg. No.: PH22207

    Working Since Aug, 2022

  • Nandini Bajaj

    Email: nandini.ar200802@inst.ac.in

    Reg. No.: 10BB20A67002

    Working Since Aug, 2020

  • Amit B Tewari

    Email: amit.ph20203@inst.ac.in

    Reg. No.: PH20203

    Working Since Aug, 2020

  • MS. VISHAKHA

    Email: vishakha.ph21229@inst.ac.in

    Reg. No.: PH21229

    Working Since Aug, 2021

  • Ms. Tashmeen Kaur

    Email: tashmeen.ph19232@inst.ac.in

    Reg. No.: PH19232

    Working Since Jan, 2020

  • Ms.Priyanka

    Email: priyanka.ph17230@inst.ac.in

    Reg. No.: PH17230

    Working Since Jan, 2018

Interns

  • Anamika Saini

    Email: anamika.nsn@gmail.com

    Reg. No.: IN2021-4

    Working Since Jul, 2021

Research Associates

  • Dr Anjali Chauhan

    Email: anjalichauhan1988@gmail.com

    Reg. No.: RA202114


PhD Students

  • Ruby Gupta

    Email: ruby.ph16201@inst.ac.in

    Reg. No.: PH16201


Project - JRF/SRF

  • Amit Tewari

    Email: abt.amit@gmail.com

    Reg. No.: RP571923


  1. Transmigration of magnetite nanoparticles across the blood-brain barrier in a rodent model: Influence of external and alternating magnetic field.: Ruby Gupta, Anjali Chauhan, Tashmeen Kaur, Bijoy Kumar Kuanr Sharma, Deepika, (2022) Nanoscale, . DOI: DOI https://doi.org/10.1039/D2NR02210A

  2. Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer’s disease: Bhupinder Kapoor, Monika Gulati, Pooja Rani, Rajpal Singh Kochhar, Atanas G. Atanasov, Reena Gupta, Deepika Sharma, Deepak Kapoor, (2022) BioFactors, . DOI: https://doi.org/10.1002/biof.1910

  3. Green synthesis of biocompatible superparamagnetic iron oxide-gold composite nanoparticles for magnetic resonance imaging, hyperthermia and photothermal therapeutic applications: Sharad Gupta , Prashant Kharey, Manish Goel, Zakir Husain, Ruby Gupta, Deepika Sharma,Manikandan M, I.A.Palani, (2022) Materials Chemistry and Physics, 293: 126859. DOI: https://doi.org/10.1016/j.matchemphys.2022.126859

  4. Expansion of thermometry in magnetic hyperthermia cancer therapy: antecedence and aftermath: Tashmeen Kaur , Deepika Sharma, (2022) Nanomedicine: Future Medicine, . DOI: https://doi.org/10.2217/nnm-2022-0095

  5. Deciphering the Interdependent Labyrinth between Gut Microbiota and the Immune System: Anamika Saini, Priyanka Dalal, Deepika Sharma, (2022) Letters in Applied Microbiology, . DOI: https://doi.org/10.1111/lam.13775

  6. Tailoring nanoparticles design for enhanced heating efficiency and improved magneto-chemo therapy for glioblastoma: RubyGupta, Tashmeen Kaur, Anjali Chauhan, Ravi Kumar, Bijoy K Kuanr, Deepika Sharma, (2022) Biomaterials Advances, 139: 213021. DOI: https://doi.org/10.1016/j.bioadv.2022.213021

  7. Indispensable role of microbes in anticancer drugs and discovery trends: Ridham Kapoor, Anamika Saini, Deepika Sharma, (2022) Appl Microbiol Biotechnol, . DOI: https://doi.org/10.1007/s00253-022-12046-2

  8. Near-infrared active superparamagnetic iron oxide nanoparticles for magnetomotive optical coherence tomography imaging and magnetic hyperthermia therapeutic applications: PrashantKharey,Abhishek Indoliya,RubyGupta,RajuPoddar,Deepika Sharma,SharadGupta, (2022) Journal of Magnetism and Magnetic Materials, 549: 169038. DOI: https://doi.org/10.1016/j.jmmm.2022.169038

  9. Microbe defines the efficacy of chemotherapeutic drug: a complete paradigm.: Priyanka Dalal,Deepika Sharma, (2021) FEMS Microbiology letters, 368: . DOI: https://doi.org/10.1093/femsle/fnab116

  10. (Carboxymethyl-stevioside)-coated magnetic dots for enhanced magnetic hyperthermia and improved glioblastoma treatment: Deepika Sharma,Ruby Gupta, (2021) Colloids and Surfaces B: Biointerfaces, 205: 111870. DOI: https://doi.org/10.1016/j.colsurfb.2021.111870

  11. Effect of manganese doping on the hyperthermic profile of ferrite nanoparticles using response surface methodology: Ruby Gupta, Ruchi Tomar,Suvankar Chakraverty,Deepika Sharma, (2021) RSC Advances, 11: 16942-16954. DOI: 10.1039/D1RA02376D

  12. Therapeutic response differences between 2D and 3D tumor models of magnetic hyperthermia: Ruby Gupta,Deepika Sharma, (2021) Nanoscale Advances, . DOI: 10.1039/D1NA00224D

  13. In Vitro Anti-tumoral and Anti-bacterial Activity of an Octamolybdate Cluster-Based Hybrid Solid Incorporated with a Copper Picolinate Complex: Joshi A,Gupta R,Vaghasiya K,Verma R.K,Sharma D,Singh M, (2021) ACS Applied Bio Materials, 3(7): 4025–4035. DOI: https://doi.org/10.1021/acsabm.0c00093

  14. A Mo(vi) based coordination polymer as an antiproliferative agent against cancer cells: Arti Joshi,Ruby Gupta,Deepika Sharma,Monika Singh, (2020) Dalton Transactions, 50: 1253-1260. DOI: http://dx.doi.org/10.1039/D0DT03865B

  15. Biomineralized and Chemically Synthesized Magnetic Nanoparticles: A Contrast.: Nanda T,Rathode A,Sharma D, (2020) Frontiers of Materials Science, 14(4): 387–401. DOI: https://doi.org/10.1007/s11706-020-0531-7

  16. Formation of diamond nanostructures from graphite using 10 W fibre laser.: Verma A,Prakash B,Sharma D, (2020) Bulletin of Materials Science, 43(1): 1-5. DOI: https://doi.org/10.1007/s12034-020-02255-8

  17. First report of isolation of Aeromonas taiwanensis from India.: Nanda T,Sharma D., (2020) New Microbes and New Infections, 36: 100721. DOI: https://doi.org/10.1016/j.nmni.2020.100721

  18. Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid: Arti Joshi,Ruby Gupta,Bharti Singh,Deepika Sharma,Monika Singh, (2020) Dalton Trans, 49: 7069-7077. DOI: https://doi.org/10.1039/D0DT01042A

  19. Near-infrared-responsive silver-capped magnetic nanoclusters for cancer therapy.: Tewari A,Gupta R,Sharma D, (2020) Journal of Radiation and Cancer Research, 11: 45-51. DOI: https://doi.org/10.4103/jrcr.jrcr_19_20

  20. Manganese-Doped Magnetic Nanoclusters for Hyperthermia and Photothermal Glioblastoma Therapy.: Ruby Gupta and Deepika Sharma, (2020) ACS Applied Nano Materials, 3: 2026-2037. DOI: 10.1021/acsanm.0c00121).

  21. Evolution of Magnetic Hyperthermia for Glioblastoma Multiforme Therapy: Ruby Gupta, Deepika Sharma, (2019) ACS Chemical Neuroscience, 10(3): 1157-1172. DOI: 10.1021/acschemneuro.8b00652

  22. Cellulose nanofibers from lignocellulosic biomass of lemongrass using enzymatic hydrolysis: characterization and cytotoxicity assessment: Priyanka Kumari, Gauri Pathak,Ruby Gupta, Deepika Sharma,Abha Meena, (2019) DARU Journal of Pharmaceutical Sciences, 27: 683–693. DOI: https://doi.org/10.1007/s40199-019-00303-1

  23. Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications.: Ruby Gupta, (2019) International Journal of Hyperthermia, 36(1): 302-312. DOI: 10.1080/02656736.2019.1565787

  24. Biocompatible ferrite nanoparticles for hyperthermia: effect of polydispersity, anisotropy energy and inter-particle interaction: Neha Wadhera, Ruby Gupta,Bhanu Prakash,D Sharma,Suvankar, (2017) Materials Research Express, 4: 025037. DOI: 10.1088/2053-1591/aa5d93

  25. Enzyme assisted extraction of bioactives from plants.: Munish Puri,Collin J. Barrow, (2012) Trends in Biotechnology, 30(1): 37-44. DOI: 10.1016/j.tibtech.2011.06.014

  26. Optimization of novel method for the extraction of stevioside from Stevia rebaudianaleaves: Munish Puri, Collin J Barrow, Ashok K Tiwary, (2012) Food Chemistry, 132(3): 1113-1120. DOI: 10.1016/j.foodchem.2011.11.063

  27. Antibacterial activity of stevioside towards food borne pathogenic bacteria: Munish Puri, (2011) Engineering in Life Science, 11(3): 326-329. DOI: 10.1002/elsc.201000142

  28. Downstream processing of stevioside and its potential applications: Munish Puri,Ashok K Tiwary, (2011) Biotechnology Advances, 29(6): 781-79. DOI: 10.1016/j.biotechadv.2011.06.006

  1. Multifunctional Bioactives- Nano-sized Delivery Systems for Cancer. In: Food Bioactives Extraction and Biotechnology Applications: Springer Comm., (2017) Ch12: 299-323.

  1. Evolution of Hyperthermia for Cancer Therapy and its Present Prospective in 6th world congress on Nanomedical Sciences-ISNSCON-2018”, “Chemistry-Biology Interface 2019” and “Conference on “Sc: Vigyan Bhawan, New Delhi, (2019) .

  2. Functionalization and Application of Magnetite Nanoparticles as Hyperthermic agents: Effect on the Size and Magnetic Properties in eBBT-2018 at: IIT Indore, (2018) .

  3. Validation of Cancer Metastasis through Microfluidic Approach in: 8th BANGALORE INDIA NANO, (2016) .

  4. Biocompatible Ferrite Nanoparticles for Hyperthermia: Effect of Polydispersity, Anisotropy Energy and Inter-particle Interaction in: 1st INST In-house Symposium, (2016) .

  5. Validation of Cancer Metastasis through Microfluidic Approach in 2nd CRIKC: Nanoscience Day, (2016) .

  6. Validation of Cancer Metastasis through Microfluidic Approach in 2nd India International Science: Festival, (2016) .

  7. Magnetic Nanoparticles as an Efficient heat mediators for tumour therapy in GLOBAL CANCER SUMMIT held at: Indian Institute of Science Bengaluru, (2015) .

  8. Nanodiamond mediated bone metastasis inhibition in Organ-on-a-chip in 2nd AISRF Meeting on Advanced Nanomaterials for Energy,: Optoelectronics and Biological Applications, (2015) .

  9. Evaluating Potential of Noncalorie Sweetener in Masking Bitter Taste of Drugs in BRSI International Conference on Industrial: Biotechnology, (2012) .

  10. Nanomedicine for Cancer. 3rd International Conference on Stem Cells and Cancer: (ICSCC-2012), (2012) .

  11. DBT and UGC Sponsored National Seminar on Biotech Vistas-2011 held at Department of Biotechnology,: Punjabi University, Patiala, (2011) .

  12. Training programme on HPTLC organized by Science and Technology Entrepreneur’s Park (STEP) conducted at Thapar University: Patiala, (2010) .

  13. Applications and Importance of Laboratory Animals in Biomedical Research at National Institute of Research in Reproductive Health (NIRRH): Mumbai, (2009) .

  14. Biotech- Present and Future Perspective held at Biotech Department: Punjabi University, Patiala, (2009) .

  15. Downstream Processing of Stevioside from Stevia rebaudianaBertoni (SrB): an attempt to explore its Microbicidal Potential in BRSI International conference on Emerging Trends in: Biotechnology, (2009) .

  16. Workshop on Patents & IPR at: Chitkara Institute, Punjab, (2007) .

  17. National Symposium on Horizons of Biotechnology held at Department of Biotechnology,: Punjabi University, Patiala, (2006) .

Fundings

  • Temozolomide delivery across blood brain barrier through nanomagnetic transducer: A targeted therapy for Glioblastoma multiforme. 2019-2021, SERB, DST
    Funding Amount: 46,93,973
    PI: Dr. Deepika Sharma

  • 2013

    Ph.D

    Department of Biotechnology, Punjabi University, Patiala, India

  • 2007

    M.Sc

    Department of Biotechnology, Punjabi University, Patiala, India

  • 2005

    B.Sc

    Panjab University, Chandigarh, India

  • Scientist D:Institute of Nano Science and Technology, Knowledge City, Sector 81, Mohali-140306, Punjab, India. (January 2022 to Present till date )

  • Scientist C:Institute of Nano Science and Technology, Phase 10, Sector 64, Mohali 160062, Punjab, India (January 2019 to December 2021 )

  • Scientist B:Institute of Nano Science and Technology, Phase 10, Sector 64, Mohali 160062, Punjab, India (January 2015 to December 2018 )

  • DBT Research Associate:Institute of Nano Science and Technology, Phase 10, Sector 64, Mohali 160062, Punjab, India (July 2013 to December 2014 )

  • Lecturer:Department of Biotechnology, Multani Mal Modi College, Patiala, Punjab, India. (April 2011 to June 2013 )

Awards & Honours

  • Department of Biotechnology (DBT) Research Associateship (2013-2015).

  • Punjab State Scholarship for merit in Graduation (2005).

  • Awarded by Roll of Honour during Graduation (2005).


Professional Recognitions

  • Member of Chandigarh Region Innovation and Knowledge Cluster (CRIKC)

  • Member of Indian Association for Hyperthermic Oncology and Medicine (IAHOM)

  • Member of Indian Association of Cancer Research (IACR)

  • Member of Biotech Research Society of India (BRSI)

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