Host specific drug nanoparticles

High Drug Loading Nanoparticles Stabilized with Autologous Serum Proteins Passively Inhibits Tumor Growth

We report drug nanocrystals stabilized with host specific serum proteins with high loading (~63% w/w). The human serum derived curcumin nanoparticles (Cur-NanoSera) showed superior in vitro anti-cancer efficiency compared to free drug with substantial hemocompatibility. The pre-adsorbed protein coating impeded further protein corona formation even with repeated serum exposures. Acute & sub-acute toxicity evaluation post single and dual injections of C57BL/6 mice derived Cur-NanoSera showed no prominent inflammatory response or organ damage in the in-bred mice. Passive accumulation of Cur-NanoSera in tumor tissue significantly suppressed its growth in a syngeneic breast tumor model in addition to controlling tumor burden associated splenomegaly.

More info: Mimansa, Manu Jamwal, Reena Das, Asifkhan Shanavas*, Biomacromolecules, 2022 (https://doi.org/10.1021/acs.biomac.2c00907)
Host specific drug nanoparticles