Recuperative effect of metformin loaded polydopamine nanoformulation promoting EZH2 mediated proteasomal degradation of phospho-α-synuclein in Parkinson's disease model
Dr. Subhasree Roy Choudhury’s research group works on neuroprotective
efficacy of nature inspired biocompatible polydopamine nanocarrier for
metformin delivery (Met encapsulated PDANPs) by crossing blood brain barrier in
in vitro, 3D and in vivo experimental Parkinson’s disease models. The
neuroprotective mechanism proved novel interaction of epigenetic regulator EZH2
mediated ubiquitination and proteasomal degradation of aggregated pSer129
α-Syn. This study divulges the neuroprotective role of Met loaded PDANPs by
reversing the neurochemical deficits by confirming an epigenetic mediated
nanotherapeutic approach for the PD prevention.
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details: Nanomedicine
2020;24:102088. doi: 10.1016/j.nano.2019.102088.
