Prof. Ganguli is the founding Director of Institute of Nano Science and Technology, India. His research area includes designing of nanostructures using microemulsions with desired size, shape, shell thickness and aspect ratio for applications in photocatalysis, photovoltaics, efficient electrocatalysis for hydrogen and oxygen evolution reactions and porous functionalised nanostructures for toxin removal and water purification.… .

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Computational Nanoscience and Surface Science, Molecular electronics:  Interpreting STM image contrast, molecular switches and sensors; Predictive modeling of hydrogen storage materials and energy relevant materials, Gas sensors, band gap engineering in nanomaterials 
Methods: First principles (ab initio) based approaches, Ab initio transport calculations, Quantum Chemistry, Monte Carlo simulation

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Targeted Combinatorial Nanomedicines for Cancer. Organo-Inorganic Biomaterials for Theranostics. Synthesis and Toxicological evaluation of affordable Biomaterials. Testing physiological fate of biomimicking nano/micro structures.

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Development of supramolecular polymeric hydrogel based biomaterials, Stimuli-responsive materials for controlled release and delivery, Dynamic combinatorial chemistry for self-healing and functional nanomaterials, Multivalent recognition for imaging and diagnostic application

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Combining microfluidics with SERS for different device based applications is the prime focus.
Fabrication of micro/nano devices for a variety of plasmonic based applications. 
SERS studies of different analyte molecules on the fabricated nanostructures.

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Thermal and electronic transport; Nanomaterials, Nanotechnology, Computational Nanoscience; Thermoelectrics, Photovoltics, Metal-Air battery and renewable energy.

 

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Nanoparticle stabilized emulsions for encapsulation and catalysis, Self-pumping films for therapeutic release, Layer-by-layer assembly of polyelectrolytes, Fabrication of 1D nanomaterial by room temperature chemical vapor deposition.

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Tissue engineering using nanostructured scaffolds. Cell delivery using nanocomposites. Addressing wound management with low cost devices.

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Research is focused on Targeted nanoparticles for treating cancer; Next-generation magnetic nanoparticles for multimodal, non-invasive tumor imaging and quantitative measurement of cancer treatments.

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Ab initio investigations of molecular magnetism, interface Nano-magnetism, molecular spintronics, magneto-structural dynamics of bimolecular systems, development of density functional theory (DFT), broken-symmetry DFT, spin constrained DFT, theoretical spectroscopy, ab initio molecular dynamics: Car-Parinello and Born-Oppenheimer molecular dynamics, classical MD, electron and spin transfer dynamics in metallo-proteins, solar cells, and catalytic chemical reactions.

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a) Ultrafast Photochemistry and Reaction Dynamics in solution phase and on nanostructured materials.

b) Design and Development of Ultrafast Laser Laboratory

c) Ultrafast charge carrier and interfacial electron and hole transfer dynamics in nanostructured and quantum dot core-shell materials using femtosecond visible, infrared and terahertz spectroscopy.

d) Synthesis, characterization and spectroscopic Analysis of alloy and doped quantum dot materials.

e) Ultrafast Proton Coupled Electron Transfer reaction

f) Working on the Mechanism of Dye-sensitized, Perovskite and Quantum Dot Solar Cell using Fast and Ultrafast spectroscopic Techniques.

g) Design and Development of Dye-sensitized Solar Cell and Quantum Dot Solar Cell.

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New synthetic methods, Functional organic materials, Supramolecular chemistry, Polymer chemistry. 
The research in my group is centred on synthetic organic chemistry with a view to exploring nanoporous and nanomaterials for various types of applications ranging from energy, catalysis, sensing, and Nanotherapeutics. Thus, it is highly interdisciplinary in nature. The general strategy of our research is designing and synthesizing the functional nanomaterials with targeted applications and understanding the properties by applying state-of-the-art characterization techniques.

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Design and synthesis of novel biocompatible and multifunctional nanostructures, mostly peptide based, for effective drug delivery across different physiological barriers like blood brain and blood ocular barriers. Designing biocompatible drug delivery systems for effective cancer therapy. Developing and characterizing different drug nanoformulations with enhanced activity. Developing smart and biocompatible scaffolds for tissue engineering applications.

 

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Advanced Functional Nanomaterials
Energy and Environmental Applications like photocatalytic water splitting, gas storage, CO2 conversion, fine chemicals production, Environmental Remediation-water purification, photovoltaics, fuel cells and batteries.
Conversion of Biomass to porous carbon based materials, Chromatographic and Biotechnology applications

 

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Advance 3D-IC packaging. CNT-TSV / Cu-TSV interconnect fabrication, Characterization & Reliability Study.   Advanced Material Synthesis for Solar Cell Application / Renewable Energy. CNT/Graphene based-FED device. Nitrogen-doped CNTs as a selective NEMS detector. Novel Graphitic VACNT coils for NMR tomography. Stacked Graphene-CNT Heterostructure with Ni-Silicide Core-Shell Architecture: High Performance. Anodes in Li-ion/air Battery

 

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Optical and electronic property study of nanomaterials; Nanofabrication of opto-electronic devices such as electron accelerators chip,   flat panel X-ray source, bolometric sensors; Applications of nanocomposites and nanomaterials in coating technology, nanofilteration and  energy devices

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Confocal  and  Electron  Microscopy,  Cellular  and  Molecular Neuroscience,  In-utero Exposures and CNS Development, Behavioral Neurology.

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Nanostructured materials and their application to make electronic devices, Low temperature stabilization of boron based materials (borane, boride and borates) and stabilization of higher oxidation states in binary and ternary metal oxides, Quantum dots based Colloidal nanostructures and their application in making flexible electronic  devices, Production and storage of H2 using nanostructured materials

 

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Small Angle X-Ray Scattering studies of nanomaterials.
Carbon dioxide sequestration using nanoporous materials using metal organic frameworks (MOF) which has emerged as a new family of nano porous materials. Synthesis and characterization of new porous ordered framework structures (MOFs and ZIFs) and to selectively capture CO2 from gas mixtures.

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Coordination activities & Scientific administration. Preparation of different Scientific and techno-feasibility report and their submission to different funding agencies like DST, DBT & CSIR and also their follow up. Involved in various collaborative projects between INST and other Institute/Universities.

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Fabrication and optical characterization of plasmonic metamaterials with a view towards nanodevices. Designing plasmonic structures for low cost sensing applications.Targeted metamaterials for clocking device and hyperlens application.

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Supramolecular synthesis of nucleic acid analogues for therapeutic and materials applications.

Luminescent boron-complexes for molecular recognition and organic photovoltaics applications.

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Nanobioprobe based low cost immuno-diagnosis for clinical and environmental applications. Microfluidics based sensitive immunoassay for disease management. Targeted Nano-carriers for therapeutics.

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Engineering of NIR-sensitive nanoparticles, to apply for deep tissue hyperthermia, cargo delivery and imaging. Further to decorate these nanoparticles on graphene oxide for increase in efficiency and integration of additional function. 
Designing nanoparticles suitable for agricultural practices like nutrient, pest and diseases management.     

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Our research interest is focused on graphene-based composite materials for binder-free supercapacitor electrode in both aqueous and organic/ionic liquid phase, hybrid supercapacitor with battery or biofuel cell for clean and self-sustainable energy storage devices, paper-based biofuel cell and electrochemical study of nanoporous materials.

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Pharmaceutical Nanotechnology and Drug delivery systems. Development of nanoparticulate delivery systems and biomaterials for receptor based targeting, controlled release and depot effect of therapeutic agents/vaccine to their site of action. Designing of polymeric particulate delivery systems (Nano and micro systems) using Supercritical fluid technology, spray drying, spray freeze drying, and Microfluidizer techniques. Preclinical therapeutic and toxicological evaluation in cells lines and animal models.

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Synthetic Lethality and Cancer
Cancer Chemoprevention
Targeted Cancer Therapy by small molecule inhibitors/nano-formulations.

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Our research focuses on design and development of new biofunctional nanomaterials based on sugar-peptide conjugates using molecular self-assembly approach. These supramolecular nanomaterial scaffolds will be explored towards solving the problems of biology (e.g. drug delivery, cancer therapy, diagonistics) and energy resources.

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Designing, synthesis and characterization of nanomaterials for Phosphors, Photocatalytic water oxidation (Artificial Photosynthesis), hydrogen generation and thermochemical production of H2, CO from H2O, CO2 splitting. 

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My laboratory is interested in physical and biophysical property studies of protein nanostructures from the shell proteins of bacterial microcompartments (BMCs). BMCs are huge, polyhedral shaped all protein structures found within many bacteria. Inside the BMCs there are specific enzymes that carry on a biological process and these enzymes are surrounded by an envelope of protein sheet. We are trying to explore the properties of these sheets and exploit them for different real life uses

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Targeted drug delivery to infectious diseases,
Non invasive diagnostics tools for infectious diseases,
Cancer Nanotherapeutics

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Design of anisotropic, core-shell and self-assembled nanostructures with ideal and controllable morphology, size, and structurewith improved performance for solving persistent issues related to energy and environment.The nanostructures designed are studied for their photocatalytic and electrocatalytic applications. Understanding the self-assembled behaviour of nanostructures.

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Development of target specific nanotherapeutics for epigenetic regulation of cancer. Chemoprevention and mechanism of action of drug/siRNA loaded nanoparticle mediated therapy for leukemia, neuroblastoma and glioblastoma. New drug development from natural products and combination therapy against cancer. Development and application of high-throughput functional gene-based screening for cancer. Multiple retrovirus and lentivirus mediated gene delivery for target validation and functional implication in cancer.

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Development of cancer nano-therapeutics including screening of peptide and small molecule combinatorial therapy, siRNA delivery and peptide-mediated cancer therapy by targeting mitochondrial metabolism. Understanding molecular mechanisms to overcome resistance to chemotherapy, target validation, signal transduction in membrane proteins and nanoparticles endocytotic cascade. Receptor and ion channel regulation on cell membrane organization, endosomal function and escape.

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Designing (and understanding the physical properties) of new materials with integrated functionalities for spin-electronics (spintronics / skyrmionics) devices in the form of thin films and interfaces with atomic scale control and monitoring the growth process using laser molecular beam epitaxy method.  

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Fabrication of Plasmonic nanostructures based on DNA origami, Nano-Bio-Interactions study using Single-Molecule Fluorescence Spectroscopy, Development of DNA-directed self-assembled Nanoantennas to get strong Fluorescence enhancement for biomolecular assays and sensing applications, Design of nanostructures materials with unidirectional energy transfer for developing efficient light harvesting systems.

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Nano-materials mediated catalysis for organic transformations

Engineered nanomaterials for Air/Water purification

The design and synthesize new nanoscale materials and structures with an emphasis on rational control of morphology, size, structure, composition and doping of metal carbides and nitrides on multiple scales for electrocatalytic applications.

Nano structured composite materials for photoelectrochemical applications.

Rechargeable Metal-Air Batteries and hybrid energy storage devices.

Active catalysts for Oxygen Reduction Reaction for Nonaqueous Li-Air Batteries

Development of low cost, stable and efficient electrocatalyst for development of PEMFC; MOF based polymer electrolyte

 

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